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Three-dimensional structures of laccases

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Abstract

Laccases are phenol oxidases that belong to the family of multi-copper oxidases and the superfamily of cupredoxins. A number of potential industrial applications for laccases have led to intensive structure-function studies and an increased amount of crystal structures has been solved. The objective of this review is to summarize and analyze available crystal structures of laccases. The experimental crystallographic data are now easily available from the websites and electron density maps can be used for the interpretation of the structural models. The crystal structures can give valuable insights into the functional mechanisms and may serve as the basis for the development of laccases for industrial applications.

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Acknowledgements

The work was supported by the Academy of Finland (Project 256937 and 263931).

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  1. Department of Chemistry, University of Eastern Finland, Joensuu Campus, PO Box 111, 80101, Joensuu, Finland

    N. Hakulinen & J. Rouvinen

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  2. J. Rouvinen
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Correspondence to J. Rouvinen.

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Hakulinen, N., Rouvinen, J. Three-dimensional structures of laccases. Cell. Mol. Life Sci. 72, 857–868 (2015). https://doi.org/10.1007/s00018-014-1827-5

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