Abstract
B cells mediate humoral immune response and contribute to the regulation of cellular immune response. Members of the Nuclear Factor kappaB (NF-κB) family of transcription factors play a major role in regulating B-cell functions. NF-κB subunit c-Rel is predominantly expressed in lymphocytes, and in B cells, it is required for survival, proliferation, and antibody production. Dysregulation of c-Rel expression and activation alters B-cell homeostasis and is associated with B-cell lymphomas and autoimmune pathologies. Based on its essential roles, c-Rel may serve as a potential prognostic and therapeutic target. This review summarizes the current understanding of the multifaceted role of c-Rel in B cells and B-cell diseases.
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This work was supported by the National Institute of Health, NIH/NIAID grants R21AI144264 and R01AI116730 to P.R.
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Basavarajappa, S.C., Ramakrishnan, P. Regulation of B-cell function by NF-kappaB c-Rel in health and disease. Cell. Mol. Life Sci. 77, 3325–3340 (2020). https://doi.org/10.1007/s00018-020-03488-w
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DOI: https://doi.org/10.1007/s00018-020-03488-w