Abstract
The synthesized nine aza-podophyllotoxin derivatives (8a–f, 10, 12 and 14) have been evaluated for their cytotoxicity in a panel of tumor cancer cell lines (Zr-75-1, MCF7, KB, Gurav, DWD, Colo-205, A-549 and Hop62). Among them, 8a and 8b compounds show stronger growth inhibition activity than the standard drug etoposide. Further, molecular docking simulations were carried out against human topoisomerase II, a putative target for these classes of molecules.
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Hatti, I., Sreenivasulu, R., Jadav, S.S. et al. Synthesis, cytotoxic activity and docking studies of new 4-aza-podophyllotoxin derivatives. Med Chem Res 24, 3305–3313 (2015). https://doi.org/10.1007/s00044-015-1375-z
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DOI: https://doi.org/10.1007/s00044-015-1375-z