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Neuroprotective effect of bisabolangelone on hydrogen peroxide-induced neurotoxicity in SH-SY5Y cells

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Abstract

Bisabolangelone is the main active ingredient of Angelica polymorpha, which has the good pharmacological activities such as anti-celialgia, anti-dysmenorrhea and anti-gastralgia. In this study, the neuroprotective effect of bisabolangelone against hydrogen peroxide (H2O2)-induced neurotoxicity in human neuroblastoma cells was studied. The binding capacity between bisabolangelone and calcium channel was calculated by molecular docking method, and calcium concentration was detected by the calcium fluorescent probe of Fura-2 AM. The results indicated that bisabolangelone had a good neuroprotective effect on nerve cells by interacting with calcium channels, mainly blocking the voltage-gated calcium channels, suppressing calcium releasing from the calcium store.

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Acknowledgments

This research was supported by Natural Science Foundation of China (Nos. 30970296, 31370373, 21102084, 81202905) and Natural Science Foundation of Hubei Province (No. 2014CFB684).

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Authors and Affiliations

  1. Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Science, China Three Gorges University, Yichang, 443002, Hubei, China

    Jun-Zhi Wang, Xi-Ming Yan, Hua-Jun Luo, Nian-Yu Huang & Wei-Qiao Deng

  2. Medical College, China Three Gorges University, Yichang, 443002, Hubei, China

    Zi-Cheng Li

  3. Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, Liaoning, China

    Wei-Qiao Deng

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  1. Jun-Zhi Wang
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  2. Xi-Ming Yan
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  3. Zi-Cheng Li
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  4. Hua-Jun Luo
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  5. Nian-Yu Huang
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  6. Wei-Qiao Deng
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Correspondence to Hua-Jun Luo.

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Wang, JZ., Yan, XM., Li, ZC. et al. Neuroprotective effect of bisabolangelone on hydrogen peroxide-induced neurotoxicity in SH-SY5Y cells. Med Chem Res 24, 3813–3820 (2015). https://doi.org/10.1007/s00044-015-1421-x

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  • DOI: https://doi.org/10.1007/s00044-015-1421-x

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