Abstract
Background:
Paragangliomas are rare, hypervascularized benign tumors. In some cases a clear differentiation of paragangliomas and other entities is impossible.
Patients and Methods:
The authors evaluated ten patients with skull base lesions (paraganglioma n = 7, meningioma n = 1, giant cell tumor n = 1, and neurinoma n = 1) in addition to conventional magnetic resonance imaging (MRI) with diffusion-weighted imaging (DWI), and calculation of apparent diffusion coefficient (ADC).
Results:
Mean ADC values ± standard deviation of the paragangliomas were 1.304 ± 0.257 × 10–3 mm2/s and differed from ADC values of the other jugular fossa tumors with 0.743 ± 0.108 × 10–3 mm2/s and measurement derived from the cerebellum with 0.802 ± 0.075 × 10–3 mm2/s.
Conclusion:
Due to the difference of ADC values, the authors propose that DWI and ADC mapping could be a promising tool in the diagnostic work-up of paragangliomas.
Zusammenfassung
Hintergrund:
Paragangliome sind seltene benigne Tumoren. In wenigen Fällen ist jedoch eine Abgrenzung zu wichtigen Differentialdiagnosen nicht möglich.
Patienten und Methodik:
In die vorliegende Studie wurden zehn Patienten mit Raumforderungen der Schädelbasis eingeschlossen; sieben Glomus-jugulare-Tumoren, ein Meningeom, ein Neurinom und ein Riesenzelltumor. Zusätzlich zur konventionellen MR-Bildgebung wurden eine Diffusionsbildgebung (DWI) und ein apparentes Diffusionskoeffizienten- (ADC-)Mapping durchgeführt.
Ergebnisse:
Die mittleren ADC-Werte ± Standardabweichung lagen für die Glomustumoren bei 1,304 ± 0,257 × 10–3mm2/s, für die Vergleichsgruppe bei 0,743 ± 0,108 × 10–3 mm2/s und 0,802 ± 0,075 × 10–3 mm2/s für das angrenzende Kleinhirn.
Schlussfolgerung:
Aufgrund der deutlichen Unterschiede der ADC-Werte scheinen die DWI und das ADC-Mapping in der Diagnostik von Glomustumoren einen wertvollen Beitrag leisten zu können.
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*Published in part at the 43rd Annual Meeting of the American Society of Neuroradiology, May 23, 2005, Toronto, Canada.
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Aschenbach, R., Basche, S., Vogl, T.J. et al. Diffusion-Weighted Imaging and ADC Mapping of Head-and-Neck Paragangliomas. Clin Neuroradiol 19, 215–219 (2009). https://doi.org/10.1007/s00062-009-9004-1
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DOI: https://doi.org/10.1007/s00062-009-9004-1