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Kutanes Plattenepithelkarzinom unter Berücksichtigung besonderer Patientengruppen

Cutaneous squamous cell carcinoma: A review with consideration of special patient groups

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Zusammenfassung

Die malignen epithelialen Tumore haben eine steigende Inzidenz. Das kutane Plattenepithelkarzinom (PEK) ist ein Tumor des höheren Lebensalters. Aufgrund der steigenden Lebenserwartung ist mit einer zunehmenden Häufigkeit der Erkrankung zu rechnen. In der Regel hat das PEK eine gute Prognose. Die Therapie besteht in der mikroskopisch kontrollierten Chirurgie des Tumors. Fortgeschrittene und metastasierte PEK stellen dagegen eine therapeutische Herausforderung dar. Bei Patienten mit Lymphknotenmetastasen liegen die 10-Jahres-Überlebensraten unter 20 %, bei Patienten mit Fernmetastasen unter 10 %. Immunsupprimierte haben ein erhöhtes Metastasierungsrisiko. Der Beitrag gibt eine Übersicht über das PEK unter besonderer Berücksichtigung der Patientengruppen, die einem erhöhten Risiko ausgesetzt sind.

Abstract

The incidence of non-melanoma skin cancer (NMSC) is increasing. Squamous cell carcinoma of the skin (SCC) is a tumor of the elderly. Due to the increasing life expectancy, SCC will become more and more frequent in the future. Generally SCC has a favorable prognosis. Standard therapy is microscopically- controlled excision. Therapy of advanced and metastatic SCC is still challenging. Patients with regional lymph node metastasis have ten-year survival rates less than 20 %; patients with distant metastases less than 10 %. Immunosuppression has been shown to be one of the key prognostic factors for metastasis. The article reviews SCC and focusses on patients being at risk for an unfavorable course.

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Einhaltung ethischer Richtlinien

Interessenkonflikt. M. Ulrich: Vortragshonorare, Studien und Beratung: Almirall, Leo. R. Gutzmer: Vortragshonorare, medizinische Beratung, Studien, Projektunterstützung von Leo, Almirall, Pfizer, Novartis, MerckSerono. U. Leiter: Vortragshonorare: Roche, Meda, Novartis. A.S. Lonsdorf: Vortragshonorare, medizinische Beratung: Galderma Laboratories GmbH. C. Ulrich: Vortragshonorare, medizinische Beratung und Studien von Galderma, Meda, Leo, Urgo, Almirall, Roche, Pfizer, Novartis, 3M. U. Hillen, M. Alter, J.C. Becker und A. Messerschmidt geben an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

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Authors and Affiliations

  1. Klinik für Dermatologie, Universitätsklinikum Essen, Westdeutsches Tumorzentrum, Universität Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Deutschland

    U. Hillen

  2. Dermatologie am Regierungsviertel, Berlin, Deutschland

    M. Ulrich

  3. Allgemeine Dermatologie, Medizinische Universität Graz, Graz, Österreich

    M. Alter

  4. Klinik für Dermatologie, Allergologie und Venerologie, Medizinische Hochschule Hannover, Hannover, Deutschland

    J.C. Becker & R. Gutzmer

  5. Zentrum für Dermato-Onkologie, Universitäts-Hautklinik, Eberhard-Karls-Universität Tübingen, Tübingen, Deutschland

    U. Leiter

  6. Universitäts-Hautklinik, Ruprecht-Karls-Universität Heidelberg, Heidelberg, Deutschland

    A. Lonsdorf

  7. Klinik für Dermatologie, Allergologie und Venerologie, Universitätsklinikum Frankfurt, Frankfurt am Main, Deutschland

    A. Messerschmidt

  8. Klinik für Dermatologie, Venerologie und Allergologie, Hauttumor Centrum, Charité Universitätsmedizin Berlin, Charité Campus Mitte, Berlin, Deutschland

    M. Ulrich & C. Ulrich

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  1. U. Hillen
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  2. M. Ulrich
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  3. M. Alter
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  4. J.C. Becker
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  6. U. Leiter
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  7. A. Lonsdorf
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  8. A. Messerschmidt
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  9. C. Ulrich
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Correspondence to U. Hillen.

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Für das Komitee „Epitheliale Tumore“ der ADO.

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Hillen, U., Ulrich, M., Alter, M. et al. Kutanes Plattenepithelkarzinom unter Berücksichtigung besonderer Patientengruppen. Hautarzt 65, 590–599 (2014). https://doi.org/10.1007/s00105-013-2734-7

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