Zusammenfassung
Viele Studien bestätigen das klinische Interesse an der photodynamischen Diagnostik (PDD) zur Behandlung des nicht muskelinvasiven Harnblasenkarzinoms. Die PDD oder Fluoreszenzzystoskopie ist bei der Detektion okkulter Urothelkarzinome von großem Wert und mag einen positiven Einfluss auf die rezidivfreie Überlebenszeit und die Prognose haben. Dennoch wird ihre Spezifität mit hoher Variabilität, hauptsächlich in Relation mit den verschiedenen Krankheitsprofilen, in den einzelnen Studien angegeben. Neue Bildgebungstechniken zur Verbesserung der visuellen Beurteilung der Harnblasenwand werden daher entwickelt.
Abstract
Many studies confirm the clinical interest of photodynamic diagnostics (PDD) in non-muscle invasive bladder cancer management. PDD or fluorescence cystoscopy is not only of great value in occult urothelial cancer detection, but may have a positive impact on disease-free survival and prognosis. Yet, its specificity is found to be highly variable between studies mainly in relation to different disease profiles. New imaging techniques aimed at enhancing visualization to assess the bladder wall are under development.
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Interessenkonflikt
Der korrespondierende Autor weist auf folgende Beziehung hin: Prof. P. Jichlinski wird ein Konferenzhonorar von GE-Healthcare in 2008 bekommen. Trotz des möglichen Interessenkonflikts ist der Beitrag unabhängig und produktneutral.
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Jichlinski, P., Lovisa, B., Erling, C. et al. Fluoreszenzzystoskopie. Urologe 47, 975–977 (2008). https://doi.org/10.1007/s00120-008-1778-2
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DOI: https://doi.org/10.1007/s00120-008-1778-2
Schlüsselwörter
- Harnblasenkarzinom
- Nicht muskelinvasives Harnblasenkarzinom
- Photodynamische Diagnostik (PDD)
- Fluoreszenzzystoskopie
- Hexaminolävulinsäure
- HAL