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Understanding host–pathogen interaction

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Fig. 1

References

  1. Mogensen TH (2009) Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev 22:240–273. doi:10.1128/CMR.00046-08

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Iwasaki A, Medzhitov R (2015) Control of adaptive immunity by the innate immune system. Nat Immunol 16:343–353. doi:10.1038/ni.3123

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Nish S, Medzhitov R (2011) Host defense pathways: role of redundancy and compensation in infectious disease phenotypes. Immunity 34:629–636. doi:10.1016/j.immuni.2011.05.009

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Schroder K, Zhou R, Tschopp J (2010) The NLRP3 inflammasome: a sensor for metabolic danger? Science 327:296–300. doi:10.1126/science.1184003

    Article  CAS  PubMed  Google Scholar 

  5. Wree A, Eguchi A, McGeough MD et al (2014) NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice. Hepatology 59:898–910. doi:10.1002/hep.26592

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Hotchkiss RS, Monneret G, Payen D (2013) Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach. Lancet Infect Dis 13:260–268. doi:10.1016/S1473-3099(13)70001-X

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Boomer JS, To K, Chang KC et al (2011) Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA 306:2594–2605. doi:10.1001/jama.2011.1829

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Venet F, Chung C-S, Kherouf H et al (2009) Increased circulating regulatory T cells (CD4(+)CD25 (+)CD127 (-)) contribute to lymphocyte anergy in septic shock patients. Intensive Care Med 35:678–686. doi:10.1007/s00134-008-1337-8

    Article  PubMed  Google Scholar 

  9. Liu Y-C, Chan K-G, Chang C-Y (2015) Modulation of host biology by Pseudomonas aeruginosa quorum sensing signal molecules: messengers or traitors. Front Microbiol 6:1226. doi:10.3389/fmicb.2015.01226

    PubMed  PubMed Central  Google Scholar 

  10. Wu L, Estrada O, Zaborina O et al (2005) Recognition of host immune activation by Pseudomonas aeruginosa. Science 309:774–777. doi:10.1126/science.1112422

    Article  CAS  PubMed  Google Scholar 

  11. Le Berre R, Nguyen S, Nowak E et al (2011) Relative contribution of three main virulence factors in Pseudomonas aeruginosa pneumonia. Crit Care Med 39:2113–2120. doi:10.1097/CCM.0b013e31821e899f

    Article  PubMed  Google Scholar 

  12. Broquet A, Asehnoune K (2015) Apoptosis induced by Pseudomonas aeruginosa: a lonely killer? Microb Biotechnol 8:49–51. doi:10.1111/1751-7915.12144

    Article  PubMed  Google Scholar 

  13. Coburn J, Frank DW (1999) Macrophages and epithelial cells respond differently to the Pseudomonas aeruginosa type III secretion system. Infect Immun 67:3151–3154

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Davenport EE, Burnham KL, Radhakrishnan J et al (2016) Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study. Lancet Respir Med 4:259–271. doi:10.1016/S2213-2600(16)00046-1

    Article  PubMed  PubMed Central  Google Scholar 

  15. Vega-Ramos J, Roquilly A, Asehnoune K, Villadangos JA (2014) Modulation of dendritic cell antigen presentation by pathogens, tissue damage and secondary inflammatory signals. Curr Opin Pharmacol 17:64–70. doi:10.1016/j.coph.2014.07.013

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

The authors gratefully acknowledge Antoine Cales for preparing Fig. 1.

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Authors and Affiliations

  1. Department of Anesthesiology and Critical Care Medicine, Hôtel Dieu, Centre hospitalier universitaire (CHU) de Nantes, 44000, Nantes, France

    K. Asehnoune

  2. Department of Microbiology and Immunology, Peter Doherty Institute, The University of Melbourne Victoria, Melbourne, Australia

    J. Villadangos

  3. Department of Biochemistry and Molecular Biology, Bio21 Institute, Melbourne, Australia

    J. Villadangos

  4. Departments of Anesthesiology, Medicine, and Surgery, Washington University School of Medicine, St Louis, MO, USA

    R. S. Hotchkiss

Authors
  1. K. Asehnoune
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  2. J. Villadangos
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  3. R. S. Hotchkiss
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Corresponding author

Correspondence to K. Asehnoune.

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Asehnoune, K., Villadangos, J. & Hotchkiss, R.S. Understanding host–pathogen interaction. Intensive Care Med 42, 2084–2086 (2016). https://doi.org/10.1007/s00134-016-4544-8

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  • DOI: https://doi.org/10.1007/s00134-016-4544-8

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