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Activation of the calcium sensing receptor stimulates gastrin and gastric acid secretion in healthy participants

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Abstract

Summary

In 17 adults on a fixed metabolic diet, an 11-day course of cinacalcet increased serum gastrin and basal gastric acid output, but not maximal gastric acid output, compared with a placebo. These findings indicate that the calcium sensor receptor plays a role in the regulation of gastric acid.

Introduction

Gastric acid secretion is a complex process regulated by neuronal and hormonal pathways. Ex vivo studies in human gastric tissues indicate that the calcium sensing receptor (CaR), expressed on the surface of G and parietal cells, may be involved in this regulation. We sought to determine whether cinacalcet, a CaR allosteric agonist, increases serum gastrin and gastric acid secretion.

Methods

Seventeen healthy adults with normal gastric acid output were placed on an 18-day metabolic diet. On day 8 (baseline), participants were given cinacalcet (15 then 30 mg/day) or placebo for 11 days. Changes in gastric acid output, serum gastrin, and other measures were compared in the two groups.

Results

Changes in serum gastrin and basal acid output (adjusted for baseline body weight) were significantly more positive in the cinacalcet group compared with placebo (P = 0.004 and P = 0.039 respectively). Change in maximal acid output was similar in the two groups (P = 0.995). As expected, cinacalcet produced significant decreases in serum PTH (P < 0.001) and ionized calcium levels (P = 0.032), and increases in serum phosphorus levels (P = 0.001) and urinary calcium (P = 0.023).

Conclusions

This study provides in vivo evidence that activation of the CaR increases serum gastrin levels and basal gastric acid secretion in healthy adults.

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Acknowledgements

We are grateful to the staff of the Metabolic Research Unit at the Jean Mayer USDA HNRCA at Tufts University for assistance in carrying out on this study. LC, SSH, HMR, and BD-H contributed to the design, analysis, and writing of the manuscript. BD-H obtained the funding. LC was supported by the Dr. Gerald J. and Dorothy R. Friedman New York Foundation for Medical Research Grant and a National Institutes of Health Institutional Research Training grant T32 DK007651–16.

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Authors and Affiliations

  1. Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA, 02111, USA

    L. Ceglia, S. S. Harris, H. M. Rasmussen & B. Dawson-Hughes

Authors
  1. L. Ceglia
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  2. S. S. Harris
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  3. H. M. Rasmussen
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  4. B. Dawson-Hughes
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Corresponding author

Correspondence to L. Ceglia.

Additional information

Clinical Trial: NCT00336739

This material is based upon work supported by the US Department of Agriculture, Agricultural Research Service, under agreement No. 58–1950–7–707. Any opinions, findings, conclusion, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the view of the US Dept of Agriculture.

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Ceglia, L., Harris, S.S., Rasmussen, H.M. et al. Activation of the calcium sensing receptor stimulates gastrin and gastric acid secretion in healthy participants. Osteoporos Int 20, 71–78 (2009). https://doi.org/10.1007/s00198-008-0637-8

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  • DOI: https://doi.org/10.1007/s00198-008-0637-8

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