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DC insulator dielectrophoretic applications in microdevice technology: a review

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Abstract

Dielectrophoresis is a noninvasive, nondestructive, inexpensive, and fast technique for the manipulation of bioparticles. Recent advances in the field of dielectrophoresis (DEP) have resulted in new approaches for characterizing the behavior of particles and cells using direct current (DC) electric fields. In such approaches, spatial nonuniformities are created in the channel by embedding insulating obstacles in the channel or flow field in order to perform separation or trapping. This emerging field of dielectrophoresis is commonly termed DC insulator dielectrophoresis (DC-iDEP), insulator-based dielectrophoresis (iDEP), or electrodeless dielectrophoresis (eDEP). In many microdevices, this form of dielectrophoresis has advantages over traditional AC-DEP, including single material microfabrication, remotely positioned electrodes, and reduced fouling of the test region. DC-iDEP applications have included disease detection, separation of cancerous cells from normal cells, and separation of live from dead bacteria. However, there is a need for a critical report to integrate these important research findings. The aim of this review is to provide an overview of the current state-of-art technology in the field of DC-iDEP for the separation and trapping of inert particles and cells. In this article, a review of the concepts and theory leading to the manipulation of particles via DC-iDEP is given, and insulating obstacle geometry designs and the characterization of device performance are discussed. This review compiles and compares the significant findings obtained by researchers in handling and manipulating particles.

Common insulating obstacle geometries reported in the literature. Red zones indicate where the particles experience the maximum dielectrophoretic effect under DC or DC plus AC-biased electric field conditions

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Acknowledgements

The authors would like to thank the financial support provided by NSF CAREER 0644538 and stimulating conversations with Blanca Lapizco-Encinas.

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  1. Soumya K. Srivastava

    Present address: Gene and Linda Voiland School of Chemical Engineering and Bioengineering, Washington State University, Pullman, WA, 99164, USA

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  1. Dave C. Swalm School of Chemical Engineering, Mississippi State University, Starkville, MS, 39762, USA

    Soumya K. Srivastava

  2. Department of Chemical Engineering, Michigan Technological University, 1400 Townsend Drive, Houghton, MI, 49931, USA

    Aytug Gencoglu & Adrienne R. Minerick

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Srivastava, S.K., Gencoglu, A. & Minerick, A.R. DC insulator dielectrophoretic applications in microdevice technology: a review. Anal Bioanal Chem 399, 301–321 (2011). https://doi.org/10.1007/s00216-010-4222-6

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