Abstract
The applicability of hollow-fibre liquid-phase microextraction for extracting 2-chlorovinyldichloroarsine (lewisite 1), bis(2-chlorovinyl)chloroarsine (lewisite 2), tris(2-chlorovinyl)arsine (lewisite 3) and arsenic trichloride from aqueous samples is reported. Parameters affecting the extraction efficiency of these chemicals were optimised. These parameters included the type of derivatising agent, extraction solvent, derivatisation method, pH, ionic strength, stirring speed and extraction time. A linear range between 0.002 and 0.2 μg/mL was established for the lewisites with good square regression coefficients (0.9955–0.9992). Good reproducibility with relative standard deviations (RSDs) from 8 to 10 % was achieved. The limit of detection was 0.002 μg/mL for the lewisites and 0.005 μg/mL for arsenic trichloride (3:1 signal-to-noise ratio). The extraction method was validated with a proficiency test sample issued by the Organisation for the Prohibition of Chemical Weapons (OPCW). The rapidity and precision of the new method should help deter against the employment of lewisite as a chemical warfare agent: its use could be confirmed easily from analysis of aqueous samples.
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Acknowledgments
Support from the Organic Synthesis Group of DSO National Laboratories is gratefully acknowledged. This work was funded by the Future Systems and Technology Directorate, Singapore. F.B.H., J.R. and C.M.T. thank Professor Vernon Gibson FRS, Chief Scientific Advisor to the UK Ministry of Defence, for his continued interest in the development of improved analytical techniques for CWAs.
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Published in the topical collection Analysis of Chemicals Relevant to the Chemical Weapons Convention with guest editors Marc-Michael Blum and R. V. S. Murty Mamidanna.
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Cheh, M.Y., Chua, H.C., Hopkins, F.B. et al. Determination of lewisite constituents in aqueous samples using hollow-fibre liquid-phase microextraction followed by gas chromatography-mass spectrometry. Anal Bioanal Chem 406, 5103–5110 (2014). https://doi.org/10.1007/s00216-014-7751-6
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DOI: https://doi.org/10.1007/s00216-014-7751-6