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Vis-NIR spectroscopy with moving-window PLS method applied to rapid analysis of whole blood viscosity

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Abstract

A rapid analytical method of human whole blood viscosity with low, medium, and high shear rates [WBV(L), WBV(M), and WBV(H), respectively] was developed using visible and near-infrared (Vis-NIR) spectroscopy combined with a moving-window partial least squares (MW-PLS) method. Two groups of peripheral blood samples were collected for modeling and validation. Separate analytical models were established for male and female groups to avoid interference in different gender groups and improve the homogeneity and prediction accuracy. Modeling was performed for multiple divisions of calibration and prediction sets to avoid over-fitting and achieve parameter stability. The joint analysis models for three indicators were selected through comprehensive evaluation of MW-PLS. The selected joint analysis models were 812–1278 nm for males and 670–1146 nm for females. The root-mean-square errors (SEP) and the correlation coefficients of prediction (RP) for all validation samples were 0.54 mPa•s and 0.91 for WBV(L), 0.25 mPa•s and 0.92 for WBV(M), and 0.22 mPa•s and 0.90 for WBV(H). Results indicated high prediction accuracy, with prediction values similar to the clinically measured values. Overall, the findings confirmed the feasibility of whole blood viscosity quantification based on Vis-NIR spectroscopy with MW-PLS. The proposed rapid and simple technique is a promising tool for surveillance, control, and treatment of cardio-cerebrovascular diseases in large populations.

The caption/legend of the online abstract figure: The selected wavebands and the prediction effects for the three indicators of whole blood viscosity

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Abbreviations

MW-PLS:

Moving-window partial least squares

PLS:

Partial least squares

RP :

Correlation coefficients for prediction

RPD:

Ratio of standard error of performance to standard deviation

SEP:

Root-mean-square errors for prediction

Vis-NIR:

Visible and near-infrared

WBV:

Whole blood viscosity

WBV(H):

Whole blood viscosity at high shear rate

WBV(L):

Whole blood viscosity at low shear rate

WBV(M):

Whole blood viscosity at medium shear rate

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Acknowledgments

This work was supported by the Science and Technology Project of Guangdong Province of China (no. 2014A020212445, no. 2014A020213016).

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Authors and Affiliations

  1. Department of Biological Engineering, Jinan University, Guangzhou, Guangdong, 510632, China

    Jiemei Chen, Zhiwei Yin & Yi Tang

  2. Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Department of Optoelectronic Engineering, Jinan University, Guangzhou, Guangdong, 510632, China

    Tao Pan

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  1. Jiemei Chen
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Correspondence to Tao Pan.

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As the blood samples were collected and used in this study, the informed consent of all individual participants was obtained.

Ethical approval

Experiments were performed in compliance with the relevant laws and institutional guidelines and approved by local medical institution.

Conflict of Interest

Jiemei Chen, Zhiwei Yin, Yi Tang, Tao Pan declare that they have no conflict of interest.

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Chen, J., Yin, Z., Tang, Y. et al. Vis-NIR spectroscopy with moving-window PLS method applied to rapid analysis of whole blood viscosity. Anal Bioanal Chem 409, 2737–2745 (2017). https://doi.org/10.1007/s00216-017-0218-9

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  • DOI: https://doi.org/10.1007/s00216-017-0218-9

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