Abstract
Aim
Undergraduate students in Jichi Medical School participated in a laboratory exercise investigating the furosemide–probenecid interaction at the end of their clinical pharmacology (CP) course. The aim of this study was to determine whether they learned to recognize drug interactions better than students who did not take such a course.
Methods
We conducted a postal survey of physicians who had graduated from Jichi Medical School or from other medical schools without a CP course including the exercise. Questions were asked concerning: (1) the recognition of furosemide–probenecid and nine other drug interactions, and (2) the need to anticipate drug interactions and their adverse effects before writing prescriptions.
Results
The degree of the recognition of all drug interactions, and the percentage of physicians who responded that knowledge of drug interactions and adverse effects were essential before writing prescriptions, were significantly greater in physicians who had taken an undergraduate CP course than in those who had not.
Conclusions
CP courses with specific laboratory exercises on drug interactions lead future physicians to recognize drug interactions and their adverse effects.
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References
Stichtenoth DO, Frolich JC (2004) Pregraduate teaching clinical pharmacology in Germany. Eur J Clin Pharmacol 60:225–229
Orme M, Frolich J, Vrhovac B (2002) Towards a core curriculum in clinical pharmacology for undergraduate medical students in Europe. Eur J Clin Pharmacol 58:635–640
Vlahovic Palcevski V, Vitezic D, Zupan G, Simonic A (1998) Education in clinical pharmacology at the Rijeka School of Medicine, Croatia. Eur J Clin Pharmacol 54:685–689
Eroglu L, Uresin Y (2003) A model of pharmacology education: the experience of Istanbul medical faculty. J Clin Pharmacol 43:237–242
Smith CM (1997) Using student feedback on examination questions to promote fairness, item validity, and learning. J Clin Pharmacol 37:379–387
Michel MC, Bischoff A, Jakobs KH (2002) Comparison of problem-and lecture-based pharmacology teaching. Trends Pharmacol Sci 23:168–170
Whiting B, Holford NH, Begg EJ (2002) Clinical pharmacology: principles and practice of drug therapy in medical education. Br J Clin Pharmacol 54:1–2
Kawaguchi A, Sugimoto K, Ohmori M, Tsuruoka S, Harada K, Kitoh Y et al (2001) Furosemide-probenecid interaction as a laboratory exercise for undergraduate education in clinical pharmacology. Clin Pharmacol Ther 69:232–237
Quinn D, Day R (1997) Clinically important drug interactions. In: Speight T, Holford N (eds) Avery’s drug treatment, 4th edn. Adis International, Auckland, pp 301–338
Guidance for Industry: drug metabolism/drug interactions in the drug development process. Studies in vitro. http://www.fda.gov/cder/guidance/clin3.pdf
Guidance for Industry: in vivo drug metabolism/drug interaction studies. Study design, data analysis, and recommendations for dosing and labeling. http://www.fda.gov/cder/guidance/2635fnl.pdf
Harada K, Fujimura A (2000) The need for improving information systems on drug interactions in Japan. Arch Intern Med 160:2063–2064
Honari J, Blair AD, Cutler RE (1977) Effects of probenecid on furosemide kinetics and natriuresis in man. Clin Pharmacol Ther 22:395–401
Pichette V, du Souich P (1996) Role of the kidneys in the metabolism of furosemide: its inhibition by probenecid. J Am Soc Nephrol 7:345–349
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Tsuruoka, S., Kawaguchi, A., Harada, K. et al. Favorable effect on postgraduate clinical practice of a drug-interaction exercise for undergraduate students. Eur J Clin Pharmacol 62, 571–576 (2006). https://doi.org/10.1007/s00228-006-0142-y
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DOI: https://doi.org/10.1007/s00228-006-0142-y