Abstract
Background
Vaginal endodermal sinus tumor is a rare entity.
Objective
The purpose of this study was to report the clinical manifestations and MRI features in a case series.
Materials and methods
Children with vaginal endodermal sinus tumor admitted to our hospitals between January 2008 and August 2012 were included. MRI was performed in all four children and diffusion-weighted imaging was performed in two children.
Results
Four children, mean age 14 months, were included. All had a history of vaginal bleeding. Serum alpha-fetoprotein was significantly elevated on admission. Relative to muscle, the vaginal masses were uniformly isointense on T1-weighted images, heterogeneously hyperintense on T2-weighted images and heterogeneously enhancing on contrast-enhanced images. The vaginal masses were obviously hyperintense on diffusion-weighted images (b value, 800 s/mm2). Extravaginal invasion was observed in three children. Pelvic lymphadenopathy was noted in two children and pulmonary metastasis was found in one child.
Conclusion
MRI may contribute in the evaluation of vaginal endodermal sinus tumors.
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References
Handel LN, Scott SM, Giller RH et al (2002) New perspectives on therapy for vaginal endodermal sinus tumors. J Urol 168:687–690
Tao T, Yang J, Cao D et al (2012) Conservative treatment and long-term follow up of endodermal sinus tumor of the vagina. Gynecol Oncol 125:358–361
Arafah M, Zaidi SN (2012) A case of yolk sac tumor of the vagina in an infant. Arch Gynecol Obstet 285:1403–1405
Lacy J, Capra M, Allen L (2006) Endodermal sinus tumor of the infant vagina treated exclusively with chemotherapy. J Pediatr Hematol Oncol 28:768–771
Imai A, Furui T, Yokoyama Y et al (1993) Endodermal sinus tumor of the vagina in an infant: magnetic resonance imaging evaluation. Gynecol Oncol 48:402–405
Mauz-Körholz C, Harms D, Calaminus G et al (2000) Primary chemotherapy and conservative surgery for vaginal yolk-sac tumour. Maligne Keimzelltumoren Study Group. Lancet 355:625
Liu Q, Yang J, Tao T et al (2012) The clinical features and treatment of endodermal sinus tumor of vagina. Eur J Obstet Gynecol Reprod Biol 165:130–131
Wani NA, Robbani I, Andrabi AH et al (2010) Vaginal yolk sac tumor causing infantile hydrometra: use of multidetector-row computed tomography. J Pediatr Adolesc Gynecol 23:e115–e118
Rescorla F, Billmire D, Vinocur C et al (2003) The effect of neoadjuvant chemotherapy and surgery in children with malignant germ cell tumors of the genital region: a pediatric intergroup trial. J Pediatr Surg 38:910–912
Striegel AM, Myers JB, Sorensen MD et al (2006) Vaginal discharge and bleeding in girls younger than 6 years. J Urol 176:2632–2635
Audet P, Pressacco J, Burke M et al (2000) MR imaging of female pelvic malignancies. Magn Reson Imaging Clin N Am 8:887–914
Agrons GA, Wagner BJ, Lonergan GJ et al (1997) From the archives of the AFIP. Genitourinary rhabdomyosarcoma in children: radiologic-pathologic correlation. Radiographics 17:919–937
Mardi K, Gupta N, Bindra R (2011) Primary yolk sac tumor of cervix and vagina in an adult female: a rare case report. Indian J Cancer 48:515–516
Reck-Burneo CA, Villanueva J, Velcek FT (2009) Vaginal müllerian papilloma: an unusual cause of vaginal bleeding in a toddler. J Pediatr Adolesc Gynecol 22:e124–e126
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Liu, QY., Huang, L., Lin, XF. et al. Clinical manifestations and MRI features of vaginal endodermal sinus tumors in four children. Pediatr Radiol 43, 983–990 (2013). https://doi.org/10.1007/s00247-012-2617-6
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DOI: https://doi.org/10.1007/s00247-012-2617-6