Abstract
In the current article, the dynamic evolution of two-phase vesicles is presented as an extension to a previous stationary model and based on an equilibrium of local forces. In the simplified model, ignoring the effects of membrane inertia, a dynamic equilibrium between the membrane bending potential and local fluid friction is considered in each phase. The equilibrium equations at the domain borders are completed by extended introduction of membrane section reactions. We show that in some cases, the results of stationary and evolutionary models are in agreement with each other and also with experimental observations, while in others the two models differ markedly. The value of our approach is that we can account for unresponsive points of uncertainty using our equations with the local velocity of the lipid membranes and calculating the intermediate states (shapes) in the consequent evolutionary, or response, path.
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Experimental vesicle is redrawn from (García-Sáez et al. 2007)
Fusion-budding process is redrawn from experiment by Riske et al. (2006)
Experimental vesicle is redrawn from Dimova et al. (2006)
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Abbreviations
- V:
-
Volume
- v:
-
Reduced volume
- v :
-
Membrane local velocity vector
- v :
-
Membrane normal velocity (scalar)
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Sahebifard, M., Shahidi, A. & Ziaei-Rad, S. Two-phase vesicles: a study on evolutionary and stationary models. Eur Biophys J 46, 343–350 (2017). https://doi.org/10.1007/s00249-016-1177-3
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DOI: https://doi.org/10.1007/s00249-016-1177-3