Skip to main content
Log in

Incidentally detected cystic lesions of the pancreas on CT: review of literature and management suggestions

  • Published:
Abdominal Imaging Aims and scope Submit manuscript

Abstract

Purpose

To facilitate a better understanding of incidentally noted cystic pancreatic lesions, since these lesions often pose a challenge regarding appropriate management.

Methods

This article reviews pathophysiology, prevalence, significance, and recommendations for management of the various pancreatic cystic lesions. Illustrative cases are demonstrated.

Results

Diagnostic benign lesions can be left alone. Cross-sectional imaging can be used to follow-up benign appearing lesions and to stage more aggressive ones. Endoscopic ultrasound with fine needle aspiration and cyst fluid analysis can be performed on certain indeterminate lesions. Lesions with high malignant potential should undergo resection.

Conclusions

A better understanding of the variety of incidentally detected pancreatic cystic lesions can help direct appropriate management.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10
Fig. 11

Similar content being viewed by others

References

  1. Laffan TA, Horton KM, Klein AP, et al. (2008) Prevalence of unsuspected pancreatic cysts on MDCT. AJR Am J Roentgenol 191:802–807

    Article  PubMed  Google Scholar 

  2. Fernandez-del Castillo C, Targarona J, Thayer SP, et al. (2003) Incidental pancreatic cysts: clinicopathologic characteristics and comparison with symptomatic patients. Arch Surg 138:3–427 (discussion 433-4)

    Google Scholar 

  3. Hruban RH, Pitman MB, Klimstra DS (2007) Atlas of tumor pathology: tumors of pancreas, 4th edn. Washington, DC: American Registry of Pathology and Armed Forces Institute of pathology

    Google Scholar 

  4. Fernandez-del Castillo C, Warshaw AL (1995) Cystic tumors of the pancreas. Surg Clin North Am 75:1001–1016

    PubMed  CAS  Google Scholar 

  5. Compagno J, Oertel JE (1978) Microcystic adenomas of the pancreas (glycogen-rich cystadenomas): a clinicopathologic study of 34 cases. Am J Clin Pathol 69:289–298

    PubMed  CAS  Google Scholar 

  6. Sarr MG, Murr M, Smyrk TC, et al. (2003) Primary cystic neoplasms of the pancreas. Neoplastic disorders of emerging importance-current state-of-the-art and unanswered questions. J Gastrointest Surg 7:417–428

    Article  PubMed  Google Scholar 

  7. Box JC, Douglas HO (2000) Management of cystic neoplasms of the pancreas. Am Surg 66:495–501

    PubMed  CAS  Google Scholar 

  8. Curry CA, Eng J, Horton KM, et al. (2000) CT of primary cystic pancreatic neoplasms: can CT be used for patient triage and treatment? AJR Am J Roentgenol 175:99–103

    Article  PubMed  CAS  Google Scholar 

  9. Fernandez-del Castillo C, Warshaw AL (2000) Current management of cystic neoplasms of the pancreas. Adv Surg 34:237–248

    PubMed  CAS  Google Scholar 

  10. Procacci C, Biasiutti C, Carbognin G, et al. (1999) Characterization of cystic tumors of the pancreas: CT accuracy. J Comput Assist Tomogr 23:906–912

    Article  PubMed  CAS  Google Scholar 

  11. Procacci C, Graziani R, Bicego E, et al. (1997) Serous cystadenoma of the pancreas: report of 30 cases with emphasis on the imaging findings. J Comput Assist Tomogr 21:373–382

    Article  PubMed  CAS  Google Scholar 

  12. Reddy RP, Smyrk TC, Zapiach M, et al. (2004) Pancreatic mucinous cystic neoplasm defined by ovarian stroma: demographics, clinical features, and prevalence of cancer. Clin Gastroenterol Hepatol 2:1026–1031

    Article  PubMed  Google Scholar 

  13. Zamboni G, Scarpa A, Bogina G, et al. (1999) Mucinous cystic tumors of the pancreas: clinicopathological features, prognosis, and relationship to other mucinous cystic tumors. Am J Surg Pathol 23:410–422

    Article  PubMed  CAS  Google Scholar 

  14. Compagno J, Oertel JE (1978) Mucinous cystic neoplasms of the pancreas with overt and latent malignancy (cystadenocarcinoma and cystadenoma). A clinicopathologic study of 41 cases. Am J Clin Pathol 69:573–580

    PubMed  CAS  Google Scholar 

  15. Tanaka M, Chari S, Adsay V, et al. (2006) International consensus guidelines for management of intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pancreas. Pancreatology 6:17–32

    Article  PubMed  Google Scholar 

  16. Sahani DV, Lin DJ, Venkatesan AM, et al. (2009) Multidisciplinary approach to diagnosis and management of intraductal papillary mucinous neoplasms of the pancreas. Clin Gastroenterol Hepatol 7:259–269

    Article  PubMed  Google Scholar 

  17. Paal E, Thompson LD, Przygodzki RM, et al. (1999) A clinicopathologic and immunohistochemical study of 22 intraductal papillary mucinous neoplasms of the pancreas, with a review of the literature. Mod Pathol 12:518–528

    PubMed  CAS  Google Scholar 

  18. Sohn TA, Yeo CJ, Cameron JL, et al. (2004) Intraductal papillary mucinous neoplasms of the pancreas: an updated experience. Ann Surg 239:788–797 (discussion 797-9)

    Article  PubMed  Google Scholar 

  19. Manfredi R, Graziani R, Motton M, et al. (2009) Main pancreatic duct intraductal papillary mucinous neoplasms: accuracy of MR imaging in differentiation between benign and malignant tumors compared with histopathologic analysis. Radiology 253:106–115

    Article  PubMed  Google Scholar 

  20. Sadakari Y, Ienaga J, Kobayashi K, et al. (2009) Cyst size indicates malignant transformation in branch duct intraductal papillary mucinous neoplasm of the pancreas without mural nodules. Pancreas 39:232–236

    Article  Google Scholar 

  21. Guarise A, Faccioli N, Ferrari M, et al. (2008) Evaluation of serial changes of pancreatic branch duct intraductal papillary mucinous neoplasms by follow-up with magnetic resonance imaging. Cancer Imaging 8:220–228

    Article  PubMed  Google Scholar 

  22. Tanaka M (2011) Controversies in the management of pancreatic IPMN. Nat Rev Gastroenterol Hepatol 8:56–60

    Article  PubMed  Google Scholar 

  23. Woo SM, Ryu JK, Lee SH, et al. (2009) Branch duct intraductal papillary mucinous neoplasms in a retrospective series of 190 patients. Br J Surg 96:405–411

    Article  PubMed  CAS  Google Scholar 

  24. Kang MJ, Jang JY, Kim SJ, et al. (2011) Cyst growth rate predicts malignancy in patients with branch duct intraductal papillary mucinous neoplasms. Clin Gastroenterol Hepatol 9:87–93

    Article  PubMed  Google Scholar 

  25. Ogawa H, Itoh S, Ikeda M, et al. (2008) Intraductal papillary mucinous neoplasm of the pancreas: assessment of the likelihood of invasiveness with multisection CT. Radiology 248:876–886

    Article  PubMed  Google Scholar 

  26. Uehara H, Ishikawa O, Katayama K, et al. (2010) Size of mural nodule as an indicator of surgery for branch duct intraductal papillary mucinous neoplasm of the pancreas during follow-up. J Gastroenterol 46:657–663

    Article  PubMed  Google Scholar 

  27. Roger N, Rousseau G, Bardier A, et al. (2008) Lymphoepithelial cyst of the pancreas: a new case report. Gastroenterol Clin Biol 32:640–644

    Article  PubMed  CAS  Google Scholar 

  28. Shinmura R, Gabata T, Matsui O (2006) Lymphoepithelial cyst of the pancreas: case report with special reference to imaging–pathologic correlation. Abdom Imaging 31:106–109

    Article  PubMed  CAS  Google Scholar 

  29. Yang F, Jin C, Long J, et al. (2009) Solid pseudopapillary tumor of the pancreas: a case series of 26 consecutive patients. Am J Surg 198:210–215

    Article  PubMed  Google Scholar 

  30. Lee JH, Yu JS, Kim H, et al. (2008) Solid pseudopapillary carcinoma of the pancreas: differentiation from benign solid pseudopapillary tumour using CT and MRI. Clin Radiol 63:1006–1014

    Article  PubMed  CAS  Google Scholar 

  31. Sahani DV, Kadavigere R, Blake M, et al. (2006) Intraductal papillary mucinous neoplasm of pancreas: multi-detector row CT with 2D curved reformations—correlation with MRCP. Radiology 238:560–569

    Article  PubMed  Google Scholar 

  32. Sainani NI, Saokar A, Deshpande V, et al. (2009) Comparative performance of MDCT and MRI with MR cholangiopancreatography in characterizing small pancreatic cysts. AJR Am J Roentgenol 193:722–731

    Article  PubMed  Google Scholar 

  33. Waters JA, Schmidt CM, Pinchot JW, et al. (2008) CT vs MRCP: optimal classification of IPMN type and extent. J Gastrointest Surg 12:101–109

    Article  PubMed  Google Scholar 

  34. Kalb B, Sarmiento JM, Kooby DA, et al. (2009) MR imaging of cystic lesions of the pancreas. Radiographics 29:1749–1765

    Article  PubMed  Google Scholar 

  35. Song SJ, Lee JM, Kim YJ, et al. (2007) Differentiation of intraductal papillary mucinous neoplasms from other pancreatic cystic masses: comparison of multirow-detector CT and MR imaging using ROC analysis. J Magn Reson Imaging 26:86–93

    Article  PubMed  Google Scholar 

  36. Koito K, Namieno T, Ichimura T, et al. (1998) Mucin-producing pancreatic tumors: comparison of MR cholangiopancreatography with endoscopic retrograde cholangiopancreatography. Radiology 208:231–237

    PubMed  CAS  Google Scholar 

  37. Berland LL, Silverman SG, Gore RM, et al. (2010) Managing incidental findings on abdominal CT: white paper of the ACR incidental findings committee. J Am Coll Radiol 7:754–773

    Article  PubMed  Google Scholar 

  38. Sidden CR, Mortele KJ (2007) Cystic tumors of the pancreas: ultrasound, computed tomography, and magnetic resonance imaging features. Semin Ultrasound CT MR 28:339–356

    Article  PubMed  Google Scholar 

  39. Carbognin G, Pinali L, Girardi V, et al. (2007) Collateral branches IPMTs: secretin-enhanced MRCP. Abdom Imaging 32:374–380

    Article  PubMed  Google Scholar 

  40. Song MH, Lee SK, Kim MH, et al. (2003) EUS in the evaluation of pancreatic cystic lesions. Gastrointest Endosc 57:891–896

    Article  PubMed  Google Scholar 

  41. Sole M, Iglesias C, Fernandez-Esparrach G, et al. (2005) Fine-needle aspiration cytology of intraductal papillary mucinous tumors of the pancreas. Cancer 105:298–303

    Article  PubMed  Google Scholar 

  42. Attasaranya S, Pais S, LeBlanc J, et al. (2007) Endoscopic ultrasound-guided fine needle aspiration and cyst fluid analysis for pancreatic cysts. JOP 8:553–563

    PubMed  Google Scholar 

  43. Brugge WR, Lewandrowski K, Lee-Lewandrowski E, et al. (2004) Diagnosis of pancreatic cystic neoplasms: a report of the cooperative pancreatic cyst study. Gastroenterology 126:1330–1336

    Article  PubMed  Google Scholar 

  44. van der Waaij LA, van Dullemen HM, Porte RJ (2005) Cyst fluid analysis in the differential diagnosis of pancreatic cystic lesions: a pooled analysis. Gastrointest Endosc 62:383–389

    Article  PubMed  Google Scholar 

  45. Maire F, Voitot H, Aubert A, et al. (2008) Intraductal papillary mucinous neoplasms of the pancreas: performance of pancreatic fluid analysis for positive diagnosis and the prediction of malignancy. Am J Gastroenterol 103:2871–2877

    Article  PubMed  Google Scholar 

  46. Aljebreen AM, Romagnuolo J, Perini R, et al. (2007) Utility of endoscopic ultrasound, cytology and fluid carcinoembryonic antigen and CA 19-9 levels in pancreatic cystic lesions. World J Gastroenterol 13:3962–3966

    PubMed  CAS  Google Scholar 

  47. Park WG, Mascarenhas R, Palaez-Luna M, et al. (2011) Diagnostic performance of cyst fluid carcinoembryonic antigen and amylase in histologically confirmed pancreatic cysts. Pancreas 40:42–45

    Article  PubMed  CAS  Google Scholar 

  48. Snozek CL, Mascarenhas RC, O’Kane DJ (2009) Use of cyst fluid CEA, CA19-9, and amylase for evaluation of pancreatic lesions. Clin Biochem 42:1585–1588

    Article  PubMed  CAS  Google Scholar 

  49. Khalid A, Zahid M, Finkelstein SD, et al. (2009) Pancreatic cyst fluid DNA analysis in evaluating pancreatic cysts: a report of the PANDA study. Gastrointest Endosc 69:1095–1102

    Article  PubMed  Google Scholar 

  50. Fukasawa M, Maguchi H, Takahashi K, et al. (2011) Clinical features and natural history of serous cystic neoplasm of the pancreas. Pancreatology 10:695–701

    Article  Google Scholar 

  51. Khashab MA, Shin EJ, Amateau S, et al. (2011) Tumor size and location correlate with behavior of pancreatic serous cystic neoplasms. Am J Gastroenterol 106:1521–1526

    Article  PubMed  Google Scholar 

  52. Fritz S, Warshaw AL, Thayer SP (2009) Management of mucin-producing cystic neoplasms of the pancreas. Oncologist 14:125–136

    Article  PubMed  Google Scholar 

  53. Testini M, Gurrado A, Lissidini G, et al. (2010) Management of mucinous cystic neoplasms of the pancreas. World J Gastroenterol 16:5682–5692

    Article  PubMed  Google Scholar 

  54. Irie H, Yoshimitsu K, Aibe H, et al. (2004) Natural history of pancreatic intraductal papillary mucinous tumor of branch duct type: follow-up study by magnetic resonance cholangiopancreatography. J Comput Assist Tomogr 28:117–122

    Article  PubMed  Google Scholar 

  55. Cauley CE, Waters JA, Dumas RP, et al. (2011) Outcomes of primary surveillance for intraductal papillary mucinous neoplasm. J Gastrointest Surg 16:258–267

    Article  PubMed  Google Scholar 

  56. Arlix A, Bournet B, Otal P, et al. (2012) Long-term clinical and imaging follow-up of nonoperated branch duct form of intraductal papillary mucinous neoplasms of the pancreas. Pancreas 41:295–301

    Article  PubMed  Google Scholar 

  57. Maguchi H, Tanno S, Mizuno N, et al. (2011) Natural history of branch duct intraductal papillary mucinous neoplasms of the pancreas: a multicenter study in Japan. Pancreas 40:364–370

    Article  PubMed  Google Scholar 

  58. Sawai Y, Yamao K, Bhatia V, et al. (2010) Development of pancreatic cancers during long-term follow-up of side-branch intraductal papillary mucinous neoplasms. Endoscopy 42:1077–1084

    Article  PubMed  CAS  Google Scholar 

  59. Scheiman JM (2008) Management of cystic lesions of the pancreas. J Gastrointest Surg 12:405–407

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Atif Zaheer.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zaheer, A., Pokharel, S.S., Wolfgang, C. et al. Incidentally detected cystic lesions of the pancreas on CT: review of literature and management suggestions. Abdom Imaging 38, 331–341 (2013). https://doi.org/10.1007/s00261-012-9898-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00261-012-9898-y

Keywords

Navigation