Skip to main content

Advertisement

Log in

CTC technique: methods to ensure an optimal exam

  • Published:
Abdominal Radiology Aims and scope Submit manuscript

Abstract

CT colonography (CTC) has demonstrated equivalent accuracy to optical colonoscopy in the detection of clinically relevant polyps and tumors but this is only possible when technique is optimized. The two most important features of a high-quality CTC are a well-prepared colon and a distended colon. This article will discuss the dietary, bowel preparation, and fecal/fluid tagging options to best prepare the colon. Strategies to optimally distend the colon will also be discussed. CT scan techniques including patient positioning and radiation dose optimization will be reviewed. With proper technique which includes sufficient bowel preparation, fecal/fluid tagging, bowel distension, and optimized scan technique, high-quality CTC examinations should become more feasible, easier to interpret, and more consistently reproducible leading to increased utilization and increased referrals.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Reused with permission from Chang and Soto [57]

Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Reused with permission from Chang and Soto [57]

Fig. 8
Fig. 9
Fig. 10

Similar content being viewed by others

References

  1. Vining DJGD, Bechtold RE, Scharling ES, Grishaw EK, Shifrin RY (1994) Technical feasibility of colon imaging with helical CT and virtual reality. Am J Roentgenol 162:S104

    Google Scholar 

  2. Levin B, Lieberman DA, McFarland B, Smith RA, Brooks D, Andrews KS, Dash C, Giardiello FM, Glick S, Levin TR, Pickhardt P, Rex DK, Thorson A, Winawer SJ, American Cancer Society Colorectal Cancer Advisory G, Force USM-ST, American College of Radiology Colon Cancer C (2008) Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology. CA Cancer J Clin 58(3):130–160. https://doi.org/10.3322/CA.2007.0018

    Article  Google Scholar 

  3. Force USPST, Bibbins-Domingo K, Grossman DC, et al. (2016) Screening for colorectal cancer: US preventive services task force recommendation statement. JAMA 315(23):2564–2575. https://doi.org/10.1001/jama.2016.5989

    Article  Google Scholar 

  4. Reilly T, Walker G (2004) Reasons for poor colonic preparation with inpatients. Gastroenterol Nurs 27(3):115–117

    Article  PubMed  Google Scholar 

  5. Miller RE (1976) The clean colon. Gastroenterology 70(2):289–290

    CAS  PubMed  Google Scholar 

  6. Gelfand DW, Chen MY, Ott DJ (1991) Preparing the colon for the barium enema examination. Radiology 178(3):609–613. https://doi.org/10.1148/radiology.178.3.1847238

    Article  CAS  PubMed  Google Scholar 

  7. Bartram CI (1994) Bowel preparation–principles and practice. Clin Radiol 49(6):365–367

    Article  CAS  PubMed  Google Scholar 

  8. Liedenbaum MH, Denters MJ, de Vries AH, et al. (2010) Low-fiber diet in limited bowel preparation for CT colonography: influence on image quality and patient acceptance. AJR Am J Roentgenol 195(1):W31–37. https://doi.org/10.2214/AJR.09.3572

    Article  PubMed  Google Scholar 

  9. Holte K, Nielsen KG, Madsen JL, Kehlet H (2004) Physiologic effects of bowel preparation. Dis Colon Rectum 47(8):1397–1402

    Article  PubMed  Google Scholar 

  10. Beebe TJ, Johnson CD, Stoner SM, Anderson KJ, Limburg PJ (2007) Assessing attitudes toward laxative preparation in colorectal cancer screening and effects on future testing: potential receptivity to computed tomographic colonography. Mayo Clin Proc 82(6):666–671. https://doi.org/10.4065/82.6.666

    Article  PubMed  Google Scholar 

  11. Parente F, Vailati C, Bargiggia S, et al. (2015) 2-Litre polyethylene glycol-citrate-simethicone plus bisacodyl versus 4-litre polyethylene glycol as preparation for colonoscopy in chronic constipation. Dig Liver Dis 47(10):857–863. https://doi.org/10.1016/j.dld.2015.06.008

    Article  CAS  PubMed  Google Scholar 

  12. Tellez-Avila FI, Murcio-Perez E, Saul A, et al. (2014) Efficacy and tolerability of low-volume (2 L) versus single- (4 L) versus split-dose (2 L + 2 L) polyethylene glycol bowel preparation for colonoscopy: randomized clinical trial. Dig Endosc 26(6):731–736. https://doi.org/10.1111/den.12265

    Article  PubMed  Google Scholar 

  13. Macari M, Lavelle M, Pedrosa I, et al. (2001) Effect of different bowel preparations on residual fluid at CT colonography. Radiology 218(1):274–277. https://doi.org/10.1148/radiology.218.1.r01ja31274

    Article  CAS  PubMed  Google Scholar 

  14. Administration USFaD (1/8/2014) FDA warns of possible harm from exceeding recommended dose of over-the-counter sodium phosphate products to treat constipation. FDA Drug Safety Communication

  15. Heher EC, Thier SO, Rennke H, Humphreys BD (2008) Adverse renal and metabolic effects associated with oral sodium phosphate bowel preparation. Clin J Am Soc Nephrol 3(5):1494–1503. https://doi.org/10.2215/CJN.02040408

    Article  PubMed  PubMed Central  Google Scholar 

  16. Hong GS, Park SH, Kim B, et al. (2015) Simethicone to prevent colonic bubbles during CT colonography performed with polyethylene glycol lavage and iohexol tagging: a randomized clinical trial. AJR Am J Roentgenol 204(4):W429–438. https://doi.org/10.2214/AJR.14.13024

    Article  PubMed  Google Scholar 

  17. Johnson DA, Barkun AN, Cohen LB, et al. (2014) Optimizing adequacy of bowel cleansing for colonoscopy: recommendations from the US multi-society task force on colorectal cancer. Gastroenterology 147(4):903–924. https://doi.org/10.1053/j.gastro.2014.07.002

    Article  PubMed  Google Scholar 

  18. Iwano T, Tominaga M, Yamashita H, Egawa T, Ueno J (2014) Experience of low volume split-dose bowel preparation for computed tomography colonography. Nihon Hoshasen Gijutsu Gakkai zasshi 70(7):676–683

    Article  PubMed  Google Scholar 

  19. Regge D, Laudi C, Galatola G, et al. (2009) Diagnostic accuracy of computed tomographic colonography for the detection of advanced neoplasia in individuals at increased risk of colorectal cancer. JAMA 301(23):2453–2461. https://doi.org/10.1001/jama.2009.832

    Article  CAS  PubMed  Google Scholar 

  20. Johnson CD, Chen MH, Toledano AY, et al. (2008) Accuracy of CT colonography for detection of large adenomas and cancers. N Engl J Med 359(12):1207–1217. https://doi.org/10.1056/NEJMoa0800996

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Pickhardt PJ, Choi JR, Hwang I, et al. (2003) Computed tomographic virtual colonoscopy to screen for colorectal neoplasia in asymptomatic adults. N Engl J Med 349(23):2191–2200

    Article  CAS  PubMed  Google Scholar 

  22. Cotton PB, Durkalski VL, Pineau BC, et al. (2004) Computed tomographic colonography (virtual colonoscopy): a multicenter comparison with standard colonoscopy for detection of colorectal neoplasia. JAMA 291(14):1713–1719. https://doi.org/10.1001/jama.291.14.1713

    Article  CAS  PubMed  Google Scholar 

  23. Rockey DC, Paulson E, Niedzwiecki D, et al. (2005) Analysis of air contrast barium enema, computed tomographic colonography, and colonoscopy: prospective comparison. Lancet 365(9456):305–311. https://doi.org/10.1016/S0140-6736(05)17784-8

    Article  CAS  PubMed  Google Scholar 

  24. Callstrom MR, Johnson CD, Fletcher JG, et al. (2001) CT colonography without cathartic preparation: feasibility study. Radiology 219(3):693–698

    Article  CAS  PubMed  Google Scholar 

  25. Fletcher JG, Johnson CD, Welch TJ, et al. (2000) Optimization of CT colonography technique: prospective trial in 180 patients. Radiology 216(3):704–711. https://doi.org/10.1148/radiology.216.3.r00au41704

    Article  CAS  PubMed  Google Scholar 

  26. Iannaccone R, Laghi A, Catalano C, et al. (2004) Computed tomographic colonography without cathartic preparation for the detection of colorectal polyps. Gastroenterology 127(5):1300–1311

    Article  PubMed  Google Scholar 

  27. Kim DH, Hinshaw JL, Lubner MG, et al. (2014) Contrast coating for the surface of flat polyps at CT colonography: a marker for detection. Eur Radiol 24(4):940–946. https://doi.org/10.1007/s00330-014-3095-z

    Article  PubMed  PubMed Central  Google Scholar 

  28. Kim DH, Matkowskyj KA, Lubner MG, et al. (2016) Serrated polyps at CT colonography: prevalence and characteristics of the serrated polyp spectrum. Radiology 280(2):455–463. https://doi.org/10.1148/radiol.2016151608

    Article  PubMed  PubMed Central  Google Scholar 

  29. Davis PL (2015) Anaphylactoid reactions to the nonvascular administration of water-soluble iodinated contrast media. AJR Am J Roentgenol 204(6):1140–1145. https://doi.org/10.2214/AJR.15.14507

    Article  PubMed  Google Scholar 

  30. Boyce CJ, Vetter JR, Pickhardt PJ (2012) MDCT artifact related to the intra-scan gravitational flow of opacified luminal fluid (the “Dense Waterfall” sign). Abdom Imaging 37(2):292–296. https://doi.org/10.1007/s00261-011-9731-z

    Article  PubMed  Google Scholar 

  31. O’Connor SD, Summers RM, Choi JR, Pickhardt PJ (2006) Oral contrast adherence to polyps on CT colonography. J Comput Assist Tomogr 30(1):51–57

    Article  PubMed  Google Scholar 

  32. Johnson CD, Manduca A, Fletcher JG, et al. (2008) Noncathartic CT colonography with stool tagging: performance with and without electronic stool subtraction. AJR Am J Roentgenol 190(2):361–366. https://doi.org/10.2214/AJR.07.2700

    Article  PubMed  Google Scholar 

  33. Pickhardt PJ, Choi JH (2003) Electronic cleansing and stool tagging in CT colonography: advantages and pitfalls with primary three-dimensional evaluation. AJR Am J Roentgenol 181(3):799–805

    Article  PubMed  Google Scholar 

  34. Chang KJ, Rekhi SS Jr, Anderson SW, Soto JA (2011) Fluid tagging for CT colonography: effectiveness of a 2-hour iodinated oral preparation after incomplete optical colonoscopy. J Comput Assist Tomogr 35(1):91–95. https://doi.org/10.1097/RCT.0b013e3181f5a610

    Article  PubMed  Google Scholar 

  35. Neri E, Turini F, Cerri F, Vagli P, Bartolozzi C (2009) CT colonography: same-day tagging regimen with iodixanol and reduced cathartic preparation. Abdom Imaging 34(5):642–647. https://doi.org/10.1007/s00261-008-9453-z

    Article  PubMed  Google Scholar 

  36. Theis J, Kim DH, Lubner MG, Munoz-del-Rio A, Pickhardt PJ (2016) CT colonography after incomplete optical colonoscopy: bowel preparation quality at same-day vs. deferred examination. Abdom Radiol 41(1):10–18. https://doi.org/10.1007/s00261-015-0595-5

    Article  Google Scholar 

  37. Fletcher JG, Silva AC, Fidler JL, et al. (2013) Noncathartic CT colonography: image quality assessment and performance and in a screening cohort. AJR Am J Roentgenol 201(4):787–794. https://doi.org/10.2214/AJR.12.9225

    Article  PubMed  PubMed Central  Google Scholar 

  38. Zalis ME, Blake MA, Cai W, et al. (2012) Diagnostic accuracy of laxative-free computed tomographic colonography for detection of adenomatous polyps in asymptomatic adults: a prospective evaluation. Ann Intern Med 156(10):692–702. https://doi.org/10.7326/0003-4819-156-10-201205150-00005

    Article  PubMed  Google Scholar 

  39. Ghanouni A, Halligan S, Taylor SA, et al. (2014) Quantifying public preferences for different bowel preparation options prior to screening CT colonography: a discrete choice experiment. BMJ Open 4(4):e004327. https://doi.org/10.1136/bmjopen-2013-004327

    Article  PubMed  PubMed Central  Google Scholar 

  40. Ghanouni A, Halligan S, Taylor SA, et al. (2013) Evaluating patients’ preferences for type of bowel preparation prior to screening CT colonography: convenience and comfort versus sensitivity and specificity. Clin Radiol 68(11):1140–1145. https://doi.org/10.1016/j.crad.2013.06.018

    Article  CAS  PubMed  Google Scholar 

  41. Keeling AN, Slattery MM, Leong S, et al. (2010) Limited-preparation CT colonography in frail elderly patients: a feasibility study. AJR Am J Roentgenol 194(5):1279–1287. https://doi.org/10.2214/AJR.09.2896

    Article  PubMed  Google Scholar 

  42. Zalis ME, Barish MA, Choi JR, et al. (2005) CT colonography reporting and data system: a consensus proposal. Radiology 236(1):3–9

    Article  PubMed  Google Scholar 

  43. Fatima H, Johnson CS, Rex DK (2010) Patients’ description of rectal effluent and quality of bowel preparation at colonoscopy. Gastrointest Endosc 71(7):1244–1252.e1242. https://doi.org/10.1016/j.gie.2009.11.053

  44. Ben-Horin S, Bar-Meir S, Avidan B (2009) The outcome of a second preparation for colonoscopy after preparation failure in the first procedure. Gastrointest Endosc 69(3 Pt 2):626–630. https://doi.org/10.1016/j.gie.2008.08.027

    Article  PubMed  Google Scholar 

  45. Kim DH, Pickhardt PJ, Taylor AJ, et al. (2007) CT colonography versus colonoscopy for the detection of advanced neoplasia. N Engl J Med 357(14):1403–1412

    Article  CAS  PubMed  Google Scholar 

  46. Shinners TJ, Pickhardt PJ, Taylor AJ, Jones DA, Olsen CH (2006) Patient-controlled room air insufflation versus automated carbon dioxide delivery for CT colonography. AJR Am J Roentgenol 186(6):1491–1496

    Article  PubMed  Google Scholar 

  47. Burling D, Taylor SA, Halligan S, et al. (2006) Automated insufflation of carbon dioxide for MDCT colonography: distension and patient experience compared with manual insufflation. AJR Am J Roentgenol 186(1):96–103. https://doi.org/10.2214/AJR.04.1506

    Article  PubMed  Google Scholar 

  48. Saltzman HA, Sieker HO (1968) Intestinal response to changing gaseous environments: normobaric and hyperbaric observations. Ann N Y Acad Sci 150(1):31–39

    Article  CAS  PubMed  Google Scholar 

  49. Pickhardt PJ (2006) Incidence of colonic perforation at CT colonography: review of existing data and implications for screening of asymptomatic adults. Radiology 239(2):313–316

    Article  PubMed  Google Scholar 

  50. Sosna J, Blachar A, Amitai M, et al. (2006) Colonic perforation at CT colonography: assessment of risk in a multicenter large cohort. Radiology 239(2):457–463. https://doi.org/10.1148/radiol.2392050287

    Article  PubMed  Google Scholar 

  51. Bellini D, Rengo M, De Cecco CN, et al. (2014) Perforation rate in CT colonography: a systematic review of the literature and meta-analysis. Eur Radiol 24(7):1487–1496. https://doi.org/10.1007/s00330-014-3190-1

    Article  PubMed  Google Scholar 

  52. Pickhardt PJ, Bakke J, Kuo J, et al. (2014) Volumetric analysis of colonic distention according to patient position at CT colonography: diagnostic value of the right lateral decubitus series. AJR Am J Roentgenol 203(6):W623–628. https://doi.org/10.2214/AJR.13.12369

    Article  PubMed  PubMed Central  Google Scholar 

  53. Yee J, Hung RK, Akerkar GA, Wall SD (1999) The usefulness of glucagon hydrochloride for colonic distention in CT colonography. AJR Am J Roentgenol 173(1):169–172. https://doi.org/10.2214/ajr.173.1.10397121

    Article  CAS  PubMed  Google Scholar 

  54. Morrin MM, Farrell RJ, Keogan MT, et al. (2002) CT colonography: colonic distention improved by dual positioning but not intravenous glucagon. Eur Radiol 12(3):525–530. https://doi.org/10.1007/s003300100954

    Article  PubMed  Google Scholar 

  55. de Haan MC, Boellaard TN, Bossuyt PM, Stoker J (2012) Colon distension, perceived burden and side-effects of CT-colonography for screening using hyoscine butylbromide or glucagon hydrochloride as bowel relaxant. Eur J Radiol 81(8):e910–916. https://doi.org/10.1016/j.ejrad.2012.05.020

    Article  PubMed  Google Scholar 

  56. Rogalla P, Lembcke A, Ruckert JC, et al. (2005) Spasmolysis at CT colonography: butyl scopolamine versus glucagon. Radiology 236(1):184–188. https://doi.org/10.1148/radiol.2353040007

    Article  PubMed  Google Scholar 

  57. Chang KJ, Soto JA (2010) CT colonography: image display methods. In: Dachman A, Laghi A (eds) Atlas of virtual colonoscopy, 2nd edn. New York: Springer, pp 111–132

    Google Scholar 

  58. Chang KJ, Yee J (2013) Dose reduction methods for CT colonography. Abdom Imaging 38(2):224–232. https://doi.org/10.1007/s00261-012-9968-1

    Article  PubMed  Google Scholar 

  59. Lim HK, Lee KH, Kim SY, et al. (2011) Does the amount of tagged stool and fluid significantly affect the radiation exposure in low-dose CT colonography performed with an automatic exposure control? Eur Radiol 21(2):345–352. https://doi.org/10.1007/s00330-010-1922-4

    Article  PubMed  Google Scholar 

  60. Chang KJ, Caovan DB, Grand DJ, Huda W, Mayo-Smith WW (2013) Reducing radiation dose at CT colonography: decreasing kVp to 100 kilovolts. Radiology 266:801–811

    Article  Google Scholar 

  61. Chang KJ, Heisler MA, Mahesh M, Baird GL, Mayo-Smith WW (2015) CT colonography at low tube potential: using iterative reconstruction to decrease noise. Clin Radiol 70(9):981–988. https://doi.org/10.1016/j.crad.2015.05.005

    Article  CAS  PubMed  Google Scholar 

  62. Lambert L, Ourednicek P, Jahoda J, Lambertova A, Danes J (2015) Model-based vs hybrid iterative reconstruction technique in ultralow-dose submillisievert CT colonography. Br J Radiol. https://doi.org/10.1259/bjr.20140667

    Google Scholar 

  63. Lubner MG, Pooler BD, Kitchin DR, et al. (2015) Sub-milliSievert (sub-mSv) CT colonography: a prospective comparison of image quality and polyp conspicuity at reduced-dose versus standard-dose imaging. Eur Radiol 25(7):2089–2102. https://doi.org/10.1007/s00330-015-3603-9

    Article  PubMed  PubMed Central  Google Scholar 

  64. Nagata K, Fujiwara M, Kanazawa H, et al. (2015) Evaluation of dose reduction and image quality in CT colonography: comparison of low-dose CT with iterative reconstruction and routine-dose CT with filtered back projection. Eur Radiol 25(1):221–229. https://doi.org/10.1007/s00330-014-3350-3

    Article  PubMed  Google Scholar 

  65. Yamamura S, Oda S, Imuta M, et al. (2015) Reducing the radiation dose for CT colonography: effect of Low tube voltage and iterative reconstruction. Acad Radiol. https://doi.org/10.1016/j.acra.2015.03.009

    PubMed  Google Scholar 

  66. Li J, Udayasankar UK, Toth TL, et al. (2007) Automatic patient centering for MDCT: effect on radiation dose. AJR Am J Roentgenol 188(2):547–552. https://doi.org/10.2214/AJR.06.0370

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kevin J. Chang.

Ethics declarations

Funding

No relevant funding information.

Conflict of interest

KJC has no conflict of interest. DHK is co-founder of VirtuoCTC, Consultant for Viatronix, Medical Advisory Board Digitalartforms, Shareholder Cellectar, and Shareholder Elucent.

Ethical approval

This article does not contain any studies with live human participants or animals performed by any of the authors.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chang, K.J., Kim, D.H. CTC technique: methods to ensure an optimal exam. Abdom Radiol 43, 523–538 (2018). https://doi.org/10.1007/s00261-018-1499-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00261-018-1499-y

Keywords

Navigation