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18F-FDG PET/CT of hepatocellular adenoma subtypes and review of literature

  • Hepatobiliary
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Abstract

Introduction

This study evaluates 18F-FDG PET/CT imaging characteristics of pathologically proven hepatocellular adenoma (HCA) subtypes.

Methods

This is a retrospective review of an institutional database (2011–2017) for subjects with a pathologic diagnosis of hepatic adenomas established within 6 months of a pre-treatment 18F-FDG PET/CT exam. An expert pathological review by a hepatopathologist was performed to confirm diagnosis and subtype HCA. A review of the 18F-FDG PET/CT exams was performed by two board-certified nuclear radiologists in consensus. Corresponding demographic and clinical data were obtained by electronic chart review.

Results

Nine subjects were identified. An HCA subtype was established in seven subjects (4 HNF1A-mutated and 3 Inflammatory). The mean HCA lesion size was 2.8 cm (range 0.6–6.2, SD 2.0) with a mean SUVmax of 5.9 (range 2.1–18.9, SD 5.1). The SUV values of HNF1A-mutated HCA were significantly higher than inflammatory HCA: lesion SUVmax (5.3 ± 1.48 vs. 2.8 ± 0.59, p < 0.033), lesion-to-liver SUVmax ratio (1.4 ± 0.22 vs. 0.8 ± 0.21, p = 0.031), lesion SUVmean (3.6 ± 0.37 vs. 2.0 ± 0.46, p = 0.0086).

Conclusion

HNF1A-mutated HCA may have greater SUV values than inflammatory HCA on 18F-FDG PET/CT exams. However, there are contradictory data in the literature and further investigation is warranted.

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Authors and Affiliations

  1. Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA

    Jason R. Young, Sudhakar K. Venkatesh & Ayse T. Kendi

  2. Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, 55905, MN, USA

    Rondell P. Graham

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  1. Jason R. Young
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  2. Rondell P. Graham
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Correspondence to Jason R. Young.

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Young, J.R., Graham, R.P., Venkatesh, S.K. et al. 18F-FDG PET/CT of hepatocellular adenoma subtypes and review of literature. Abdom Radiol 46, 2604–2609 (2021). https://doi.org/10.1007/s00261-021-02968-2

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  • DOI: https://doi.org/10.1007/s00261-021-02968-2

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