Skip to main content
SpringerLink
Log in

Drug permeation behavior through thermo- and pH-responsive polycarbonate-g-poly(N-isopropylacrylamide-co-acrylic acid) composites

  • Original Paper
  • Published:
Polymer Bulletin Aims and scope Submit manuscript

Abstract

Poly(N-isopropylacrylamide-co-acrylic acid) hydrogel was grafted onto track-etched polycarbonate (PC) films using the free-radical polymerization method to prepare thermo-sensitive micro-porous films. Differential scanning calorimeter analysis was used to determine the lower critical solution temperature for the hydrogels. Thermo-gravimetric analysis was used to determine the thermal stability of the PC–hydrogel composite films. The composite films were characterized using Fourier transform-infrared spectra, scanning electron microscope, and effective pore diameters derived from water permeability data. 4-Acetamidophenol, citric acid, KCl, and methyl orange were used as the model drugs. For neutral drugs, the larger molecules exhibited lower permeability but higher on–off ratio than smaller ones. The strong electrolyte model molecules (KCl) exhibited depressed permeability due to enlarged hydrated ion sizes. The acidic (citric acid) model solution promoted gel shrinkage, resulting in increased drug permeability and on–off ratio.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10

Similar content being viewed by others

References

  1. Wandera D, Wickramasinghe SR, Husson SM (2010) Stimuli-responsive membranes. J Membr Sci 357:6–35

    Article  CAS  Google Scholar 

  2. Malonne H, Eeckman F, Fontaine D, Otto A, De Vos L, Moës A, Fontaine J, Amighi K (2005) Preparation of poly(N-isopropylacrylamide) copolymers and preliminary assessment of their acute and sub-acute toxicity in mice. Eur J Pharm Biopharm 61:188–194

    Article  CAS  Google Scholar 

  3. Lue SJ, Chen CH, Shih CM (2011) Tuning of lower critical solution temperature (LCST) of poly(Nisopropylacrylamide-co-acrylic acid) hydrogels. J Macromol Sci B 50:563–579

    Article  CAS  Google Scholar 

  4. Lue SJ, Chen CH, Shih CM, Tsai MC, Kuo CY, Lai JY (2011) Grafting of poly(N-isopropylacrylamide-co-acrylic acid) on micro-porous polycarbonate films: regulating lower critical solution temperatures for drug controlled release. J Membr Sci 379:330–340

    Article  CAS  Google Scholar 

  5. Fu G, Soboyejo WO (2010) Swelling and diffusion characteristics of modified poly (N-isopropylacrylamide) hydrogels. Mater Sci Eng, C 30:8–13

    Article  CAS  Google Scholar 

  6. Evingür GA, Pekcan O (2012) Effect of LCST on the swelling of PAAm-NIPA copolymers: a fluorescence study. Polym Bull 68(1):223–238

    Article  Google Scholar 

  7. Yun J, Kim HI (2012) Dual-responsive release behavior of pH-sensitive PVA/PAAc hydrogels containing temperature-sensitive PVA/PNIPAAm microcapsules. Polym Bull 68(4):1109–1119

    Article  CAS  Google Scholar 

  8. Yang B, Yang W (2003) Thermo-sensitive switching membranes regulated by pore-covering polymer brushes. J Membr Sci 218:247–255

    Article  CAS  Google Scholar 

  9. Spohr R, Reber N, Wolf A, Alder GM, Ang V, Bashford CL, Pasternak CA, Hideki O, Yoshida M (1998) Thermal control of drug release by a responsive ion track membrane observed by radio tracer flow dialysis. J Control Release 50:1–11

    Article  Google Scholar 

  10. Ramírez-Fuentes YS, Bucio E, Burillo G (2008) Thermo and ph sensitive copolymer based on acrylic acid and N-isopropylacrylamide grafted onto polypropylene. Polym Bull 60:79–87

    Article  Google Scholar 

  11. Ikram S, Kumari M, Gupta B (2011) Thermo sensitive membranes by radiation-induced graft polymerization of N-isopropyl acrylamide/acrylic acid on polypropylene nonwoven fabric. Radiat Phys Chem 80:50–56

    Article  CAS  Google Scholar 

  12. Meléndez-Ortiz HI, Bucio E (2008) Radiation synthesis of a thermo-pH responsive binary graft copolymer (PP-g-DMAEMA)-g-NIPAAm by a two step method. Polym Bull 61(5):619–629

    Article  Google Scholar 

  13. Lue SJ, Hsu JJ, Wei TC (2008) Drug permeation modeling through the thermo-sensitive membranes of poly(N-isopropylacrylamide) brushes grafted onto micro-porous films. J Membr Sci 321:146–154

    Article  CAS  Google Scholar 

  14. Kuroki H, Ohashi H, Ito T, Tamaki T, Yamaguchi T (2010) Isolation and analysis of a grafted polymer onto a straight cylindrical pore in a thermal-responsive gating membrane and elucidation of its permeation behavior. J Membr Sci 352:22–31

    Article  CAS  Google Scholar 

  15. Wang W, Tian X, Feng Y, Cao B, Yang W, Zhang L (2010) Thermally on-off switching membranes prepared by pore-filling poly(N-isopropylacrylamide) hydrogels. Ind Eng Chem Res 49:1684–1690

    Article  CAS  Google Scholar 

  16. Lue SJ, Hsu JJ, Chen CH, Chen BC (2007) Thermally on-off switching membranes of poly(N-isopropylacrylamide) immobilized in track-etched polycarbonate films. J Membr Sci 301:142–150

    Article  CAS  Google Scholar 

  17. Wan LS, Yang YF, Tian J, Hu MX, Xu ZK (2009) Construction of comb-like poly(N-isopropylacrylamide) layers on micro-porous polypropylene membrane by surface-initiated atom transfer radical polymerization. J Membr Sci 327:174–181

    Article  CAS  Google Scholar 

  18. Pan K, Zhang X, Ren R, Cao B (2010) Double stimuli-responsive membranes grafted with block copolymer by ATRP method. J Membr Sci 356:133–137

    Article  CAS  Google Scholar 

  19. Chou FY, Shih CM, Tsai MC, Chiu WY, Lue SJ (2012) Functional acrylic acid as stabilizer for synthesis of smart hydrogel particles containing a magnetic Fe3O4 core. Polymer 53:2839–2846

    Article  CAS  Google Scholar 

  20. Chou FY, Lai JY, Shih CM, Lue SJ, In vitro biocompatibility of magnetic thermo-responsive nano-hydrogel particles of poly(N-isopropylacrylamide-co-acrylic acid) with Fe3O4 cores: effect of particle size and chemical composition. Colloids Surf B (in revision)

Download references

Acknowledgments

We thank the National Science Council of Taiwan for financial support (NSC 100-2815-C- 182-001-E).

Author information

Authors and Affiliations

  1. Department of Chemical and Materials Engineering, Chang Gung University, Kwei-shan, Taoyuan, 333, Taiwan

    Meng-Chao Tsai, Chao-Ming Shih & Shingjiang Jessie Lue

Authors
  1. Meng-Chao Tsai
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Chao-Ming Shih
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Shingjiang Jessie Lue
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Shingjiang Jessie Lue.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tsai, MC., Shih, CM. & Lue, S.J. Drug permeation behavior through thermo- and pH-responsive polycarbonate-g-poly(N-isopropylacrylamide-co-acrylic acid) composites. Polym. Bull. 70, 1003–1017 (2013). https://doi.org/10.1007/s00289-012-0865-0

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00289-012-0865-0

Keywords

Search

Navigation