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Hypertrophic pulmonary osteoarthropathy (HPOA) (Pierre Marie–Bamberger syndrome): two cases presenting as acute inflammatory arthritis. Description and review of the literature

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Abstract

We report the cases of two middle-aged male smokers who presented to the early synovitis clinic with an acute phase response, synovitis of the wrists and ankles and clubbing of the fingers, but no respiratory symptoms. Both proved to have primary lung tumours with hypertrophic pulmonary osteoarthropathy, in one case resolving promptly with treatment of the carcinoma. We review the literature, including theories on pathogenesis.

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References

  1. Martinez-Lavin M, Mansilla J, Pineda C, Pijoan C (1994) Evidence of hypertrophic pulmonary osteoarthropathy in human skeletal remains from prehispanic Mesoamerica. Ann Int Med 12:238–241

    Google Scholar 

  2. Martinez-Lavin M, Pineda C, Valdez T et al (1988) Primary hypertrophic osteoarthropathy. Semin Arthritis Rheum 17:156–162

    Article  PubMed  CAS  Google Scholar 

  3. Yacoub MH (1965) Cervical vagotomy for pulmonary osteoarthropathy. Br J Chest 59:28–31

    Article  CAS  Google Scholar 

  4. Stenseth JH, Clagett OT, Woolner LB (1967) Hypertrophic pulmonary osteoarthropathy. Dis Chest 52:62–68

    PubMed  CAS  Google Scholar 

  5. Segal AM, MacKenzie AH (1982) Hypertrophic osteoarthropathy: a 10 year retrospective analysis. Semin Arthritis Rheum 12:220–232

    Article  PubMed  CAS  Google Scholar 

  6. Nishi K, Matsumura M, Myou S et al (1994) Two cases of pulmonary hypertrophic osteoarthropathy associated with primary lung cancer, in which symptoms were rapidly improved by resection of the primary lesions. Nihon Kyobu Shikkan Gakkai Zasshi 32:271–276

    PubMed  CAS  Google Scholar 

  7. Suteanu S, Rohan C, Gherasim E, Stoica V (1992) Hypertrophic osteoarthropathy secondary to bronchopulmonary cancer (our experience). Rom J Int Med 30:281–284

    CAS  Google Scholar 

  8. Staalman CR, Umans U (1993) Hypertrophic osteoarthropathy in childhood malignancy. Med Pediatr Oncol 21:676–679

    Article  PubMed  CAS  Google Scholar 

  9. Sridhar KS, Lobo CF, Altman RD (1998) Digital clubbing and lung cancer. Chest 114:1535–1537

    PubMed  CAS  Google Scholar 

  10. Schumacher R (1976) Articular manifestations of hypertrophic pulmonary osteoarthropathy in bronchogenic carcinoma. Arthritis Rheum 19:629–635

    Article  PubMed  Google Scholar 

  11. Rutherford RB, Rhodes BA, Wagner HN Jr (1969) The distribution of extremity blood flow before and after vagectomy in a patient with hypertrophic pulmonary osteoarthropathy. Dis Chest 56(1):19–23

    PubMed  CAS  Google Scholar 

  12. Gosney MA, Gosney JR, Lye M (1990) Plasma growth hormone and digital clubbing in carcinoma of the bronchus. Thorax 45:545–547

    Article  PubMed  CAS  Google Scholar 

  13. Hojo S, Fujita J, Yamadori I et al (1997) Hepatocyte growth factor and digital clubbing. Intern Med 36:44–46

    PubMed  CAS  Google Scholar 

  14. Uchisanko H, Suga K, Tanaka N et al (1995) Bone scintigraphy in growth-hormone-secreting pulmonary cancer and hypertrophic pulmonary osteoarthropathy. J Nucl Med 99:662–671

    Google Scholar 

  15. Dickinson CJ, Martin JF (1987) Megakaryocytes and platelet clumps as the cause of finger clubbing. Lancet 14:6–8

    Google Scholar 

  16. Marinez-Levin M, Pineda C (2003) Hypertrophic osteoarthropathy. In: Hochberg MC, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH (eds) Rheumatology, 3rd edn. Mosby, Edinburgh, pp 1763–1767

    Google Scholar 

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Authors and Affiliations

  1. Department of Rheumatology, Musgrave Park Hospital, Belfast, BT9 7JB, UK

    David J. Armstrong, Elisabeth M. A. McCausland & Gary D. Wright

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  1. David J. Armstrong
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  2. Elisabeth M. A. McCausland
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  3. Gary D. Wright
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Correspondence to David J. Armstrong.

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Armstrong, D.J., McCausland, E.M.A. & Wright, G.D. Hypertrophic pulmonary osteoarthropathy (HPOA) (Pierre Marie–Bamberger syndrome): two cases presenting as acute inflammatory arthritis. Description and review of the literature. Rheumatol Int 27, 399–402 (2007). https://doi.org/10.1007/s00296-006-0224-2

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  • DOI: https://doi.org/10.1007/s00296-006-0224-2

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