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Intracranial manifestations in SAPHO syndrome: the first case report in literature

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Abstract

A 41-year-old woman with SAPHO syndrome presented with numbness of her left arm followed by a generalized seizure. Computed tomography and magnetic resonance imaging of the brain revealed a small ring enhancing lesion in the right parietal lobe with adjacent meningeal thickening and enhancement. Surgical removal and histopathology showed evidence of severe chronic sterile inflammation and no malignant cell. Symptoms recurred and a lesion were again detected on radiological follow-up, but improvement occurred following treatment with antibiotics and biphosphonate, achieving a low inflammatory activity, reduction in CNS lesions and relative clinical well-being. This is a first report in literature about the central nervous system involvement in a patient with SAPHO syndrome.

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The authors declare that they have no conflicts of interest.

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Authors and Affiliations

  1. Faculty of Medicine, Lund University, Diagnostic Centre for Imaging and Functional Medicine, Skåne University Hospital, 205 02, Malmö, Sweden

    Kasim Abul-Kasim & Tomas Nilsson

  2. Faculty of Medicine, Lund University, Department of Rheumatology, Skåne University Hospital, 205 02, Malmö, Sweden

    Carl Turesson

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  1. Kasim Abul-Kasim
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  2. Tomas Nilsson
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  3. Carl Turesson
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Correspondence to Kasim Abul-Kasim.

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Abul-Kasim, K., Nilsson, T. & Turesson, C. Intracranial manifestations in SAPHO syndrome: the first case report in literature. Rheumatol Int 32, 1797–1799 (2012). https://doi.org/10.1007/s00296-010-1464-8

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  • DOI: https://doi.org/10.1007/s00296-010-1464-8

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