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Efficacy of infliximab in the treatment for dermatomyositis with acute interstitial pneumonia: a study of fourteen cases and literature review

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Abstract

This retrospective study assessed the efficacy of infliximab therapy in 14 patients with dermatomyositis with acute interstitial pneumonia. Ten patients starting treatment at an early stage of the disease achieved satisfactory relief, while four patients treated at a late stage failed to respond to the treatment and died.

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Abbreviations

AIP:

Acute interstitial pneumonia

AST:

Aspartate aminotransferase

CADM:

Clinical amyopathic dermatomyositis

CKP:

Creatine phosphokinase

CRP:

C-reactive protein

CT:

Computed tomography

DM:

Dermatomyositis

DM-ILD:

Dermatomyositis complicated with interstitial lung disease

IFX:

Infliximab

IgG:

Immunoglobulin G

ILD:

Interstitial lung disease

LDH:

Lactate dehydrogenase

PaO2 :

Arterial partial pressure of oxygen

PA-aO2 :

Alveolar-arterial oxygen tension difference

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Authors and Affiliations

  1. Division of Rheumatology, First Affiliated Hospital, Wenzhou Medical College, 2 Fuxue Lane, Zhejiang, Wenzhou, China

    Dan Chen, Xiao-bing Wang, Yan Zhou & Xiao-chun Zhu

Authors
  1. Dan Chen
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  2. Xiao-bing Wang
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  3. Yan Zhou
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  4. Xiao-chun Zhu
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Correspondence to Xiao-chun Zhu.

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Chen, D., Wang, Xb., Zhou, Y. et al. Efficacy of infliximab in the treatment for dermatomyositis with acute interstitial pneumonia: a study of fourteen cases and literature review. Rheumatol Int 33, 2455–2458 (2013). https://doi.org/10.1007/s00296-012-2653-4

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  • DOI: https://doi.org/10.1007/s00296-012-2653-4

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