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One novel susceptibility locus associate with systemic lupus erythematosus in Chinese Han population

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Abstract

The aim of the study is to explore additional susceptibility factors for systemic lupus erythematosus (SLE) in Chinese Hans. Based on our previous GWAS of SLE, we performed a multistage replication study involving 3,152 cases and 7,050 controls from China to identify additional susceptibility loci for SLE by using the Sequenom MassArray system. All Chinese Han samples used in this study were obtained from doctors through collaboration with multiple hospitals in two geographic regions (central and southern China). Single-marker association analyses were performed using logistic regression with gender as a covariate in each case–control cohort. The joint analysis of all combined samples was performed using logistic regression with gender and sample cohorts as covariates. The significant association evidence for rs906868 (OR = 1.14, 95 % CI 1.08–1.20, P combined = 7.71 × 10−10) and rs7579944 (OR = 1.13, 95 % CI 1.07–1.19, P combined = 5.55 × 10−9) was observed, which located at 2p23.1. In this region, limb bud and heart development homolog (LBH) was the only gene indicated, suggesting LBH might be a susceptibility gene for SLE, although its function was still unknown. The results indicated that the SNP rs7579944, rs906868 at 2p23.1 showed significant association with SLE. The genes LBH which located in this loci might be the predisposing genes of SLE.

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Acknowledgments

We thank all the participants of the study. This study was funded by the National Natural Youth Science Foundation (81101185) and An hui Provincial Natural Science Foundation (11040606Q13).

Conflict of interest

The authors declare no conflict of interest.

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Authors and Affiliations

  1. Department of Dermatology, Institute of Dermatology, the First Affiliated Hospital, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, People’s Republic of China

    Ze-Ying Yu, Sha Yao, Yun Li, Jian-Wen Han, Liang-Dan Sun, Yi-Lin Cheng, Qiang Xu, Jian Li, Yu-Jun Sheng, Xue-Jun Zhang, Yong Cui & Sen Yang

  2. Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui, People’s Republic of China

    Ze-Ying Yu, Wen-Sheng Lu, Xian-bo Zuo, Sha Yao, Yun Li, Jian-Wen Han, Liang-Dan Sun, Yi-Lin Cheng, Qiang Xu, Jian Li, Yu-Jun Sheng, Xue-Jun Zhang, Yong Cui & Sen Yang

  3. Department of Dermatology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, People’s Republic of China

    Wen-Sheng Lu

  4. Department of Anethesiology, The second people’s Hospital of Hefei City, Hefei, People’s Republic of China

    Jian Hu

Authors
  1. Ze-Ying Yu
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  2. Wen-Sheng Lu
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  3. Xian-bo Zuo
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  4. Jian Hu
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  5. Sha Yao
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  6. Yun Li
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  7. Jian-Wen Han
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  8. Liang-Dan Sun
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  9. Yi-Lin Cheng
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  10. Qiang Xu
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  11. Jian Li
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  12. Yu-Jun Sheng
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  13. Xue-Jun Zhang
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  14. Yong Cui
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  15. Sen Yang
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Corresponding authors

Correspondence to Yong Cui or Sen Yang.

Additional information

Ze-Ying Yu, Wen-Sheng Lu, Xian-bo Zuo and Jian Hu contributed equally to this work.

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Yu, ZY., Lu, WS., Zuo, Xb. et al. One novel susceptibility locus associate with systemic lupus erythematosus in Chinese Han population. Rheumatol Int 33, 2079–2083 (2013). https://doi.org/10.1007/s00296-013-2697-0

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  • DOI: https://doi.org/10.1007/s00296-013-2697-0

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