Skip to main content
Log in

Survival and changes in physical ability after coronary revascularization for octa-nonagenerian patients with acute coronary syndrome

  • Original Article
  • Published:
Heart and Vessels Aims and scope Submit manuscript

Abstract

Elderly populations are increasingly represented among patients with acute coronary syndrome (ACS), and advanced age has been identified as an important risk factor for death and adverse outcome in patients with ACS treated invasively. Although considerable data have demonstrated a prognostic benefit of early revascularization in ACS particularly in high-risk patients, elderly patients with ACS are treated invasively less often than younger patients because older age is thought to be an independent predictor of mortality after percutaneous coronary intervention (PCI) in ACS. Over the past 5 years, a total of 54 ACS patients over 85 years old were treated. The 6-month survival rate was around 50% in the non-PCI group (n = 12) and around 80% in the PCI group (n = 42) (P < 0.05). Cardiac death occurred in 6 patients in the PCI group and in 6 patients in the non-PCI group. The rates of both cardiac death and all-cause death were significantly lower in the PCI group. The change in ADL score before and 6 months after the procedure was from 1.57 to 1.59 in the PCI group and from 2.25 to 2.20 in the non-PCI group. PCI for elderly patients with ACS is safe and life saving, and does not reduce the ability to perform activities of daily living. PCI should be recommended even for octo-nonagenerians with ACS.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Bach RG, Cannon CP, Weintraub WS, DiBattiste PM, Demopoulos LA, Anderson HV, DeLucca PT, Mahoney EM, Murphy SA, Braunwald E (2004) The effect of routine, early invasive management on outcome for elderly patients with non-ST-segment elevation acute coronary syndromes. Ann Intern Med 141:186–195

    PubMed  Google Scholar 

  2. Saejueng B, Yipintsoi T, Chaisuksuwan R, Kehasukcharoen W, Boonsom W, Kanjanavanit R, Representing the Thai ACS-Registry group (2009) Factors related to in-hospital heart failure are very different for unstable angina and non-ST elevation myocardial infarction. Heart Vessels 24:399–405

    Article  PubMed  Google Scholar 

  3. Wallentin L, Lagerqvist B, Husted S, Kontny F, Ståhle E, Swahn E (2000) Outcome at 1 year after an invasive compared with non-invasive strategy in unstable coronary-artery disease: the FRISC II invasive randomized trial. FRISC II investigators. Fast revascularization during instability in coronary artery disease. Lancet 356:9–16

    Article  PubMed  CAS  Google Scholar 

  4. Cannon CP, Weintraub WS, Demopoulos LA, Vicari R, Frey MJ, Lakkis N, Neumann FJ, Robertson DH, DeLucca PT, DiBattiste PM, Gibson CM, Braunwald E (2001) TACTICS (Treat Angina with Aggrastat and Determine Cost of Therapy with an Invasive or Conservative Strategy)—Thrombolysis in Myocardial Infarction 18 Investigators: comparison of early invasive and conservative strategies in patients with unstable coronary syndromes treated with the glycoprotein IIb/IIIa inhibitor tirofiban. N Engl J Med 344:1879–1887

    Article  PubMed  CAS  Google Scholar 

  5. Spacek R, Widimský P, Straka Z, Jiresová E, Dvorák J, Polásek R, Karel I, Jirmár R, Lisa L, Budesínský T, Málek F, Stanka P (2002) Value of first day angiography/angioplasty in evolving non-ST segment elevation myocardial infarction: an open multicenter randomized trial. The VINO Study. Eur Heart J 23:230–238

    Article  PubMed  CAS  Google Scholar 

  6. Stone PH, Thompson B, Anderson HV, Kronenberg MW, Gibson RS, Rogers WJ, Diver DJ, Théroux P, Warnica JW, Nasmith JB, Kells C, Kleiman N, McCabe CH, Schactman M, Knatterud GL, Braunwald E (1996) Influence of race, sex, and age on management of unstable angina and non-Q-wave myocardial infarction: the TIMI III registry. JAMA 275:1104–1112

    Article  PubMed  CAS  Google Scholar 

  7. Giugliano RP, Camargo CA Jr, Lloyd-Jones DM, Zagrodsky JD, Alexis JD, Eagle KA, Fuster V, O’Donnell CJ (1998) Elderly patients receives less aggressive medical and invasive management of unstable angina: potential impact of practice guidelines. Arch Intern Med 158:1113–1120

    Article  PubMed  CAS  Google Scholar 

  8. Chauhan MS, Kuntz RE, Ho KL, Cohen DJ, Popma JJ, Carrozza JP, Baim DS, Cutlip DE (2001) Coronary artery stenting in the aged. J Am Coll Cardiol 37:856–862

    Article  PubMed  CAS  Google Scholar 

  9. Cannon CP (2003) Elderly patients with acute coronary syndromes: higher risk and greater benefit from antiplatelet therapy and/or interventional therapies. Am J Geriatr Cardiol 12:259–262 (Review)

    Article  PubMed  Google Scholar 

  10. McKay CR, Rich MW, Vlietstra RE, Kitzman DW, Fleg JL, Krumholz HM, Lakatta EG, Cooke JP, Cannon CP, Ezekowitz MD, Frohlich ED, Jalife J, Kass DA, Kottke BA, Muller JE, Saltin B, Shen WK, Somers VK (2000) Executive summary: pivotal research in cardiovascular syndromes in the elderly. Am J Geriatr Cardiol 9:243–250

    Article  PubMed  Google Scholar 

  11. Hasdai D, Holmes DR Jr, Criger DA, Topol EJ, Califf RM, Harrington RA (2000) Age and outcome after acute coronary syndromes without persistent ST-segment elevation. Am Heart J 139:858–866

    Article  PubMed  CAS  Google Scholar 

  12. De Servi S, Cavallini C, Dellavalle A, Santoro GM, Bonizzoni E, Marzocchi A, Politi A, Pesaresi A, Mariani M, Chierchia S (2004) ROSAI-2 Investigators: non-ST-elevation acute coronary syndrome in the elderly: treatment strategies and 30-day outcome. Am Heart J 147:830–836

    Article  PubMed  Google Scholar 

  13. Graham MM, Ghali WA, Faris PD, Galbraith PD, Norris CM, Knudtson ML (2002) Alberta Provincial Project for Outcomes Assessment in Coronary Heart Disease (APPROACH) Investigators: survival after coronary revascularization in the elderly. Circulation 105:2378–2384

    Article  PubMed  Google Scholar 

  14. Yun KH, Jeong MH, Oh SK, Rhee SJ, Park EM, Lee EM, Yoo NJ, Kim N-H, Ahn YK, Jeong J-W (2009) Response of high-sensitivity C-reactive protein to percutaneous coronary intervention in patients with acute coronary syndrome. Heart Vessels 24:175–180

    Article  PubMed  Google Scholar 

  15. Smith SC Jr, Dove JT, Jacobs AK, Kennedy JW, Kereiakes D, Kern MJ, Kuntz RE, Popma JJ, Schaff HV, Williams DO, Gibbons RJ, Alpert JP, Eagle KA, Faxon DP, Fuster V, Gardner TJ, Gregoratos G, Russell RO, Smith SC Jr (2001) American College of Cardiology; American Heart Association Task Force on Practice Guidelines. Committee to Revise the 1993 Guidelines for Percutoneous Transluminal Coronary Angioplasty: ACC/AHA guidelines of percutaneous coronary interventions (revision of the 1993 PTCA guidelines)—executive summary. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (committee to revise the 1993 guidelines for percutaneous transluminal coronary angioplasty). J Am Coll Cardiol 37:2215–2239

    Article  PubMed  Google Scholar 

  16. O’Sullivan GJ, Buckenham TM, Belli AM (1999) The use of the angio-seal haemostatic puncture closure device in high risk patients. Clin Radiol 54:51–55

    Article  PubMed  Google Scholar 

  17. Feliciano J, Fiarresga AJ, Timóteo AT, Pelicano N, Cacela D, Ferreira R, Ferreira L, Gonçalves JM, Quininha J (2005) Primary coronary angioplasty in the elderly. Rev Port Cardiol 24(2):205–214

    PubMed  Google Scholar 

  18. Galasso G, Piscione F, Furbatto F, Leosco D, Pierri A, Rosa RD, Cirillo P, Rapacciuolo A, Esposito G, Chiariello M (2008) Abciximab in elderly with acute coronary syndrome invasively treated: effect on outcome. Int J Cardiol 130(3):380–385

    Article  PubMed  Google Scholar 

  19. Walsh SJ, McAuley K, Johnston PW (2007) Percutaneous coronary intervention in the elderly. Ulster Med J 76(1):18–21

    PubMed  Google Scholar 

  20. Mehta RH, Sadiq I, Goldberg RJ, Gore JM, Avezum A, Spencer F, Kline-Rogers E, Allegrone J, Pieper K, Fox KA, Eagle KA (2004) GRACE Investigators: effectiveness of primary percutaneous coronary intervention compared with that of thrombolytic therapy in elderly patients with acute myocardial infarction. Am Heart J 147:253–259

    Article  PubMed  Google Scholar 

  21. Bhatt DL, Roe MT, Peterson ED, Li Y, Chen AY, Harrington RA, Greenbaum AB, Berger PB, Cannon CP, Cohen DJ, Saucedo JF, Kleiman NS, Hochmen JS, Boden WE, Brindis RG, Peacock WF, Smith SC Jr, Pollack CV Jr, Gibler WB, Ohman EM (2004) CRUSADE Investigators: utilization of early invasive management strategies for high-risk patients with non-ST-segment elevation acute coronary syndromes: results from the CRUSADE quality improvement initiative. JAMA 292:2096–2104

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Chuichi Kawai.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Shirasawa, K., Hwang, MW., Sasaki, Y. et al. Survival and changes in physical ability after coronary revascularization for octa-nonagenerian patients with acute coronary syndrome. Heart Vessels 26, 385–391 (2011). https://doi.org/10.1007/s00380-010-0067-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00380-010-0067-3

Keywords

Navigation