Skip to main content
SpringerLink
Log in

Initial and late efficacy of everolimus-eluting stents for small and non-small coronary lesions from evaluating delayed late loss study

  • Original Article
  • Published:
Heart and Vessels Aims and scope Submit manuscript

Abstract

The aim of the present study was to evaluate the long-term outcomes at 2 years in patients in whom everolimus-eluting stents (EESs) were implanted in small and non-small vessels. A small vessel is an important risk factor for restenosis with BMSs, even in the first generation DESs. The 690 patients with 690 lesions implanted with an EES were enrolled and divided into two groups by vessel reference diameter (RD): >2.5 mm for non-small vessels (Non-S-group) and ≤2.5 mm for small vessels (S-group). Two years later, the 365 patients with no restenosis at 8 months who underwent angiography were enrolled into the late catch-up study. At the initial 8-month follow-up, the rates of restenosis and target lesion revascularization (TLR) of both groups were not significantly different (restenosis 3.9 vs 6.5%, p = 0.17; TLR 3.9 vs 6.5%, p = 0.17). At the late 2-year follow-up, there were no significant differences in the late loss (0.36 ± 0.66 vs 0.34 ± 0.50 mm, p = 0.14), net gain (1.50 ± 0.75 vs 1.26 ± 0.60 mm, p = 0.39), late catch-up restenosis rate (5.1 vs 3.4%, p = 0.38), TLR (4.9 vs 2.7%, p = 0.40), and delayed late loss (0.14 ± 0.58 vs 0.15 ± 0.49 mm, p = 0.10) between both groups. There is no correlation between delayed late loss and RD in all patients(r = −0.009) and in AMI patients (r = −0.004). These results demonstrate that the initial and late catch-up restenosis rates of small coronary vessels with EES placement were excellent, the same as for non-small coronary vessels. We suggest that involvement of small coronary arteries may not be a risk factor for restenosis and results of stenting for small coronary arteries with EES placement were excellent.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Picchi A, Musumeci G, Calabria P, Cresti A, Rescigno R, Aruffo A, Prati F, Limbruno U (2015) Comparison of strut coverage at 6 months by optical coherence tomography with everolimus-eluting stenting of bare-metal stent restenosis versus stenosis of nonstented atherosclerotic narrowing (from the DESERT study). Am J Cardiol 115:1351–1356

    Article  PubMed  Google Scholar 

  2. Yoshida T, Sakata K, Nitta Y, Taguchi T, Kaku B, Katsuda S, Shimojima M, Gamou T, Nakahashi T, Konno T, Kawashiri MA, Yamagishi M, Hayashi K (2016) Short- and long-term benefits of drug-eluting stents compared to bare metal stents even in treatment for large coronary arteries. Heart Vessels 31(5):635–642

    Article  PubMed  Google Scholar 

  3. Piccolo R, Stefanini GG, Franzone A, Spitzer E, Blöchlinger S, Heg D, Jüni P, Windecker S (2015) Safety and efficacy of resolute zotarolimus-eluting stents compared with everolimus-eluting stents: a meta-analysis. Circ Cardiovasc Interv 8(4):e002778

    Article  Google Scholar 

  4. Lai CL, Wu CF, Kuo RN, Yang YY, Chen MF, Chan KA, Lai MS (2015) Clinical outcomes in low risk coronary artery disease patients treated with different limus-based drug-eluting stents—a nationwide retrospective cohort study using insurance claims database. PLoS One 10:e0122860

    Article  PubMed  PubMed Central  Google Scholar 

  5. Qi-Hua L, Qi Z, Yu Z, Xiao-Long L, Hai-Gang J, Jian-Feng Y, Yi S (2015) Long-term effect of second-generation drug-eluting stents for coronary artery disease, everolimus-eluting versus zotarolimus-eluting stents: a meta-analysis. Coron Artery Dis 26:259–265

    Article  PubMed  Google Scholar 

  6. Maeng M, Baranauskas A, Christiansen EH, Kaltoft A, Holm NR, Krusell LR, Ravkilde J, Tilsted HH, Thayssen P, Jensen LO (2015) 10-month angiographic and 4-year clinical outcome of everolimus-eluting versus sirolimus-eluting coronary stents in patients with diabetes mellitus (the DiabeDES IV randomized angiography trial). Catheter Cardiovasc Interv 86(7):1161–1167

    Article  PubMed  Google Scholar 

  7. Kubo S, Kadota K, Otsuru S, Hasegawa D, Habara S, Tada T, Tanaka H, Fuku Y, Katoh H, Goto T, Mitsudo K (2015) Everolimus-eluting stent implantation versus repeat paclitaxel-coated balloon angioplasty for recurrent in-stent restenosis lesion caused by paclitaxel-coated balloon failure. EuroIntervention 10:e1–e8

    Article  PubMed  Google Scholar 

  8. Lee S, Yoon CH, Oh IY, Suh JW, Cho YS, Cho GY, Chae IH, Choi DJ, Youn TJ (2015) Angiographic patterns of restenosis with 2nd generation drug-eluting stent. Int Heart J 56:6–12

    Article  PubMed  Google Scholar 

  9. Chieffo A, Buchanan GL, Parodi G, Versaci F, Bianchi RM, Valenti R, Saccà S, Mongiardo A, Span S, Migliorini A, Spaccarotella C, Reimers B, Antoniucci D, Indolfi C, Ferrari A, Maehara A, Mintz GS, Colombo A (2014) Drug-eluting stent implantation in patients with acute coronary syndrome—the activity of platelets after inhibition and cardiovascular events: optical coherence tomography (APICE OCT) study. EuroIntervention 10:916–923

    Article  PubMed  Google Scholar 

  10. Pedersen SH, Pfisterer M, Kaiser C, Jensen JS, Alber H, Rickenbacher P, Sørensen R, Iversen A, Jensen MT, Wadt K, Galatius S (2014) Drug-eluting stents and bare metal stents in patients with NSTE-ACS: 2-year outcome from the randomised BASKET-PROVE trial. EuroIntervention 10:58–64

    Article  PubMed  Google Scholar 

  11. Omar A, Torguson R, Kitabata H, Pendyala LK, Loh JP, Magalhaes MA, Satler LF, Suddath WO, Pichard AD, Waksman R (2014) Long-term safety and efficacy of second-generation everolimus-eluting stents compared to other limus-eluting stents and bare metal stents in patients with acute coronary syndrome. Catheter Cardiovasc Interv 84:1053–1060

    Article  PubMed  Google Scholar 

  12. Wang L, Zang W, Xie D, Ji W, Pan Y, Li Z, Shen J, Shi Y (2013) Drug-eluting stents for acute coronary syndrome: a meta-analysis of randomized controlled trials. PLoS One 8:e72895

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Puymirat E, Mangiacapra F, Peace A, Ntarladimas Y, Conte M, Bartunek J, Vanderheyden M, Wijns W, de Bruyne B, Barbato E (2013) Safety and effectiveness of drug-eluting stents versus bare-metal stents in elderly patients with small coronary vessel disease. Arch Cardiovasc Dis 106:554–561

    Article  PubMed  Google Scholar 

  14. Kereiakes DJ, Cannon LA, Dauber I, Ball M, Bertolet B, Foster M, Nersesov AY, Underwood PL, Allocco DJ, Dawkins KD (2015) Long-term follow-up of the platinum chromium TAXUS element (ION) stent: the PERSEUS workhorse and small vessel trial five-year results. Catheter Cardiovasc Interv 86(6):994–1001

    Article  PubMed  Google Scholar 

  15. Naganuma T, Latib A, Sgueglia GA, Menozzi A, Castriota F, Micari A, Cremonesi A, De Felice F, Marchese A, Tespili M, Presbitero P, Panoulas VF, Buffoli F, Tamburino C, Varbella F, Colombo A (2015) A 2-year follow-up of a randomized multicenter study comparing a paclitaxel drug-eluting balloon with a paclitaxel-eluting stent in small coronary vessels the BELLO study. Int J Cardiol 184:17–21

    Article  PubMed  Google Scholar 

  16. Puymirat E, Barbato E (2014) Percutaneous revascularization strategies in small-vessel disease. Ann Cardiol Angeiol 63:28–31

    Article  CAS  Google Scholar 

  17. Tajiri K, Sato A, Hoshi T, Kimura T, Nakagawa Y, Sakai S, Aonuma K, Watanabe S (2014) Mechanisms explaining the late “catch-up” phenomenon after sirolimus-eluting stent implantation. Int J Cardiol 177:44–45

    Article  PubMed  Google Scholar 

  18. Sgueglia GA, Cortese B, Gaspardone A (2013) Late catch-up phenomenon after drug-eluting balloon angioplasty. Int J Cardiol 168:638–639

    Article  PubMed  Google Scholar 

  19. Iijima R, Araki T, Nagashima Y, Yamazaki K, Utsunomiya M, Hori M, Itaya H, Shinji H, Shiba M, Hara H, Nakamura M, Sugi K (2013) Incidence and predictors of the late catch-up phenomenon after drug-eluting stent implantation. Int J Cardiol 168:2588–2592

    Article  PubMed  Google Scholar 

  20. Yang TH, Kim DI, Jin HY, Cho YW, Chung SR, Kim DK, Kim YB, Jang JS, Kim U, Seol SH, Kim DK, Kim DS (2012) Angiographic late catch-up phenomenon after sirolimus-eluting stent implantation. Int J Cardiol 160:48–52

    Article  PubMed  Google Scholar 

  21. Park DW, Hong MK, Mintz GS, Lee CW, Song JM, Han KH, Kang DH, Cheong SS, Song JK, Kim JJ, Weissman NJ, Park SW, Park SJ (2006) Two-year follow-up of the quantitative angiographic and volumetric intravascular ultrasound analysis after nonpolymeric paclitaxel-eluting stent implantation: late “catch-up” phenomenon from ASPECT study. J Am Coll Cardiol 48:2432–2439

    Article  CAS  PubMed  Google Scholar 

  22. Horita Y, Namura M, Ikeda M, Tsuchiya T, Terai H, Fukuoka R, Tama N, Takagi T (2011) Which DES is the most appropriate for very small target vessels? Experimental study of stent expandable performance with SES, PES, ZES and EES. Cardiovasc Interv Ther 26:124–130

    Article  PubMed  Google Scholar 

  23. Haase J, Escaned J, van Swijndregt EM, Ozaki Y, Gronenschild E, Slager CJ, Serruys PW (1993) Experimental validation of geometric and densitometric coronary measurements on the new generation cardiovascular angiography analysis system (CAAS II). Catheter Cardiovasc Diagn 30:104–114

    Article  CAS  Google Scholar 

  24. Kobayashi N, Ito Y, Hirano K, Yamawaki M, Araki M, Sakai T, Takimura H, Sakamoto Y, Mori S, Tsutsumi M, Takama T, Takafuji H, Maruyama T, Honda Y, Tokuda T, Makino K, Shirai S, Muramatsu T (2016) Comparison of first- and second-generation drug-eluting stent efficacies for treating left main and/or three-vessel disease: a propensity matched study. Heart Vessels 31:1930–1942

    Article  PubMed  Google Scholar 

  25. Yano H, Horinaka S, Ishikawa M, Ishimitsu T (2016) The efficacy of everolimus-eluting stent implantation in patients with ST-segment elevation myocardial infarction: outcomes of 2-year clinical follow-up. Heart Vessels 31:1609–1615

    Article  PubMed  Google Scholar 

  26. Yano H, Horikawa S, Ishikawa M, Ishimatsu T (2016) Efficacy of everolimus-eluting stent implantation in patients with small coronary arteries (≤2.5 mm): outcomes of 3-year clinical follow-up. Heart. doi:10.1007/s00380-016-0937-4

    Google Scholar 

  27. Hsieh MJ, Chen CC, Chang SH, Wang CY, Lee CH, Lin FC, Chang CJ, Hsieh IC (2013) Long-term outcomes of drug-eluting stents versus bare-metal stents in large coronary arteries. Int J Cardiol 168:3785–3790

    Article  PubMed  Google Scholar 

  28. Chan CY, Vlachos H, Selzer F, Mulukutla SR, Marroquin OC, Abbott DJ, Holper EM, Williams DO (2014) Comparison of drug-eluting and bare metal stents in large coronaries: finding from the NHLBI dynamic registry. Catheter Cardiovasc Interv 84:24–29

    Article  PubMed  Google Scholar 

  29. Sugihara M, Miura S, Nishikawa H, Ike A, Mori K, Iwata A, Kawamura A, Saku K (2013) Characteristics of patients and types of lesions in patients with drug-eluting or bare-metal stent implantation in small coronary arteries: from the FU-registry. J Cardiol 61:117–121

    Article  PubMed  Google Scholar 

  30. Obata JE, Nakamura T, Kitta Y, Saito Y, Sano K, Fujioka D, Kawabata K, Kugiyama K (2013) In-stent restenosis is inhibited in a bare metal stent implanted distal to a sirolimus-eluting stent to treat a long de novo coronary lesion with small distal vessel diameter. Catheter Cardiovasc Interv 82(6):E777–E787

    Article  PubMed  Google Scholar 

  31. Rathore S, Kaul U (2011) Percutaneous coronary intervention in small coronary vessels: from balloon angioplasty to drug eluting stent era. Indian Heart J 63:228–233

    PubMed  Google Scholar 

  32. Hansen KW, Kaiser C, Hvelplund A, Soerensen R, Madsenn JK, Jensen JS, Pedersen SH, Eberli FR, Erne P (2013) Improved 2-year outcomes after drug-eluting versus bare-metal stent implantation in women and men with large coronary arteries: importance of vessel size. Int J Cardiol 169:29–34

    Article  CAS  PubMed  Google Scholar 

  33. Kimura T, Morimoto T, Nakagawa Y, Tamura T, Kadota K, Yasumoto H, Nishikawa H, Hiasa Y, Muramatsu T, Meguro T, Inoue N, Honda H, Hayashi Y, Miyazaki S, Oshima S, Honda T, Shiode N, Namura M, Sone T, Nobuyoshi M, Kita T, Mitsudo K (2009) Antiplatelet therapy and stent thrombosis after sirolimus-eluting stent implantation. Circulation 119:987–995

    Article  CAS  PubMed  Google Scholar 

  34. Taguchi I, Yoneda S, Abe S, Toyoda S, Nasuno T, Nishino S, Kageyama M, Tokura M, Ogawa M, Node K, Inoue T (2014) The late-phase inflammatory response after drug-eluting stent implantation. Heart Vessels 29:213–219

    Article  PubMed  Google Scholar 

  35. Hasegawa K, Tamai H, Kyo E, Kosuga K, Ikeguchi S, Hata T, Okada M, Fujita S, Tsuji T, Takeda S, Fukuhara R, Kikuta Y, Motohara S, Ono K, Takeuchi E (2006) Histopathological findings of new in-stent lesions developed beyond 5 years. Catheter Cardiovasc Interv 68:554–558

    Article  PubMed  Google Scholar 

  36. Nishiyama N, Komatsu T, Kuroyanagi T, Fujikake A, Komatsu S, Nakamura H, Yamada K, Nakahara S, Kobayashi S, Taguchi I (2016) Clinical value of drug-coated balloon angioplasty for de novo lesions in patients with coronary artery disease. Int J Cardol 222:113–118

    Article  Google Scholar 

  37. Rittger H, Scheller B (2014) Drug-coated balloons in treatment of small vessel disease. Heart 100:274–275

    Article  PubMed  Google Scholar 

  38. Aoki J, Kozuma K, Awata M, Nanasato M, Shiode N, Tanabe K, Yamaguchi J, Kusano H, Nie H, Kimura T (2016) Three-year clinical outcomes of everolimus-eluting stents from the post-marketing surveillance study of cobalt-chromium everolimus-eluting stent (Xience V/PROMUS) in Japan. Circ J 80:906–912

    Article  PubMed  Google Scholar 

  39. Stone GW, Midei M, Newman W, Sanz M, Hermiller JB, Williams J, Farhat N, Mahaffey KW, Cutlip DE, Fitzgerald PJ, Sood P, Su X, Lansky AJ, Investigators SPIRITIII (2008) Comparison of an everolimus-eluting stent and a paclitaxel-eluting stent in patients with coronary artery disease: a randomized trial. JAMA 299(16):1903–1913

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Cardiovascular Medicine, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuoka Shimoaizuki, Eiheiji-cho, Fukui, 910-1193, Japan

    Naoto Tama, Hiroyasu Uzui & Hiroshi Tada

  2. Division of Cardiology, Kanazawa Cardiovascular Hospital, Kanazawa, Japan

    Yuki Horita & Masanobu Namura

Authors
  1. Naoto Tama
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hiroyasu Uzui
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yuki Horita
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Masanobu Namura
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hiroshi Tada
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Naoto Tama.

Ethics declarations

Conflict of interest

The authors have no conflict of interest to declare.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Tama, N., Uzui, H., Horita, Y. et al. Initial and late efficacy of everolimus-eluting stents for small and non-small coronary lesions from evaluating delayed late loss study. Heart Vessels 32, 1415–1423 (2017). https://doi.org/10.1007/s00380-017-1018-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00380-017-1018-z

Keywords

Search

Navigation