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Th17-Zellen – eine neue proinflammatorische T-Zell-Population und ihre Bedeutung für rheumatologische Autoimmunerkrankungen

Th17 cells – a new proinflammatory T cell population and its role in rheumatologic autoimmune diseases

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Zusammenfassung

In der Entstehung und Aufrechterhaltung von autoimmunen rheumatologischen Erkrankungen spielen CD4-T-Zellen eine wesentliche Rolle. Die kürzliche Entdeckung von Interleukin- (IL-)17-produzierenden Th17-Zellen als potente proinflammatorische T-Zell-Population erweitert das Verständnis pathophysiologischer Vorgänge, die zuvor nicht durch die Th1/Th2-Dichotomie erklärt werden konnten. Die in diesem Artikel diskutierten aktuellen Daten aus humanen Studien deuten auf eine wichtige pathogenetische Funktion von Th17-Zellen und dem von ihnen produzierten IL-17 bei zahlreichen rheumatologischen Erkrankungen hin, sodass auf Th17-Zellen/IL-17-zielende Therapien von potenziellem Nutzen in der Behandlung dieser Erkrankungen sein könnten.

Abstract

CD4 T cells play a major role in the development and persistence of autoimmune rheumatic diseases. The recent identification of IL-17-producing Th17 cells as a potent proinflammatory subset extends the understanding of pathophysiological processes not explained by the Th1/Th2 dichotomy. The recent data from human studies discussed in this article indicate an important pathogenic function for Th17 cells and Th17-derived IL-17 suggesting that therapies targeting Th17 cells/IL-17 may be of potential use in the treatment of those diseases.

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  1. Rheumaeinheit, Medizinische Poliklinik, Klinikum der Universität München, Pettenkoferstr. 8a, 80336, München, Deutschland

    J. Leipe, A. Skapenko & H. Schulze-Koops

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  1. J. Leipe
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  2. A. Skapenko
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  3. H. Schulze-Koops
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Correspondence to J. Leipe.

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Leipe, J., Skapenko, A. & Schulze-Koops, H. Th17-Zellen – eine neue proinflammatorische T-Zell-Population und ihre Bedeutung für rheumatologische Autoimmunerkrankungen. Z. Rheumatol. 68, 405–408 (2009). https://doi.org/10.1007/s00393-009-0473-z

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