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Triple stimuli-responsive polymers based on pyrene-functionalized poly(dimethylaminoethyl methacrylate): synthesis, self-assembled nanoparticles and controlled release

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Abstract

A series of photo, temperature, and pH-responsive polymers have been synthesized by the quaternization of poly(dimethylaminoethyl methacrylate) (PDMAEMA) with 1-(bromomethyl)pyrene. Nanoparticles self-assembled from the pyrene-functionalized polymers in aqueous solution are demonstrated by transmission electron microscopy (TEM) and dynamic light scattering (DLS), the morphology of which can be changed under external stimulation by UV light, temperature, and pH. With the increase of the functionalization degree, the lower critical solution temperature (LCST) and the photo response of the pyrene-functionalized polymer increases, while the critical aggregation concentration (CAC) and the pH response decreases. The controlled release of encapsulated molecules such as Nile Red (NR)and anticancer drug doxorubicin (DOX) can be achieved under the triple stimulation from the self-assembled nanoparticles.

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Acknowledgments

Financial support from the Program for New Century Excellent Talents in University (NCET-11-0582), the Fundamental Research Funds for the Central Universities (FRF-TP-12-004B), and the National Natural Science Foundation of China (Grant Nos. 51373025, 21025418, 51025313, and 51073096) are greatly acknowledged.

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Authors and Affiliations

  1. School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, 100083, People’s Republic of China

    Jie Dong, Ruichen Zhang & Guojie Wang

  2. Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing, 100871, People’s Republic of China

    Xiaowei Zhan & Huai Yang

  3. Beijing Tongren Hospital, Capital Medical University, Beijing, 100069, People’s Republic of China

    Siquan Zhu

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  1. Jie Dong
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  2. Ruichen Zhang
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  3. Xiaowei Zhan
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  4. Huai Yang
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  6. Guojie Wang
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Correspondence to Guojie Wang.

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Dong, J., Zhang, R., Zhan, X. et al. Triple stimuli-responsive polymers based on pyrene-functionalized poly(dimethylaminoethyl methacrylate): synthesis, self-assembled nanoparticles and controlled release. Colloid Polym Sci 292, 2735–2744 (2014). https://doi.org/10.1007/s00396-014-3358-x

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