Skip to main content

Advertisement

SpringerLink
Log in

The association of PASI scores with CRH-R1 expression in patients with psoriasis

  • Original Paper
  • Published:
Archives of Dermatological Research Aims and scope Submit manuscript

Abstract

Stress is a well-known triggering factor along with genetic predisposition on the onset and during the course of psoriasis by altering the cellular constituents of the immune system. In the skin, there is a local hypothalamic–pituitary–adrenal (HPA) axis which is the equivalent of the central HPA axis. Corticotropin-releasing hormone (CRH) is a major regulator of the HPA axis in response to stress. This study was planned to show the role of CRH receptor type 1 (CRH-R1) in pathogenesis of psoriasis, the relation with the severity of psoriasis, and interpersonal variance in skin biopsy specimens of the psoriasis patient. Study involved 46 patients with psoriasis and 20 healthy control subjects who were older than 18 years. The clinical sign and PASI scores of psoriasis patients were recorded. Immunohistochemically, expression of CRH-R1 was investigated in psoriatic lesions and control group skin. A statistically significant increase of the expression of CRH-R1 was found in the skin biopsies of psoriasis patients compared with the control group patients. In patients with psoriasis, there was a positive correlation between the expressions of CRH-R1 and PASI scores (p = 0.001, r = +0.572). In addition, a statistically significant increase of PASI scores was found in the intense-stained CRH-R1 group compared with the weakly stained CRH-R1 patient group. The present study has demonstrated that CRH-R1 could have a role in pathogenesis of the psoriasis and stress may increase the intensity of psoriasis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Arck PC, Slominski A, Theoharides TC, Peters EMJ, Paus R (2006) Neuroimmunology of stress: skin takes center stage. J Invest Dermatol 126:1697–1704

    Article  PubMed  CAS  Google Scholar 

  2. Arbiser JL, Karalis K, Viswanathan A et al (1999) Corticotropin-releasing hormone stimulates angiogenesis and epithelial tumor growth in the skin. J Invest Dermatol 113:838–842

    Article  PubMed  CAS  Google Scholar 

  3. Bale TL, Giordano FJ, Hickey RP, Huang Y, Nath AK, Peterson KL, Vale WW, Lee KF (2002) Corticotropin-releasing factor receptor 2 is a tonic suppressor of vascularization. Proc Natl Acad Sci USA 99:7734–7739

    Article  PubMed  CAS  Google Scholar 

  4. Buske-Kirschbaum A, Kern S, Ebrecht M, Hellhammer DH (2007) Altered distribution of leukocyte subsets and cytokine production in response to acute psychosocial stress in patients with psoriasis vulgaris. Brain Behav Immun 21:92–99

    Article  PubMed  CAS  Google Scholar 

  5. Cao J, Papadopoulou N, Kempuraj D et al (2005) Human mast cells express corticotrophin-releasing hormone (CRH) receptors and CRH leads to selective secretion of vascular endothelial growth factor. J Immunol 174:7665–7675

    PubMed  CAS  Google Scholar 

  6. Chen R, Lewis KA, Perrin MH, Vale WW (1993) Expression cloning of a human corticotropin-releasing factor 2 receptor. Proc Natl Acad Sci USA 90:8967–8971

    Article  PubMed  CAS  Google Scholar 

  7. Chrousos GP, Gold PW (1992) The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. JAMA 267:1244–1252

    Article  PubMed  CAS  Google Scholar 

  8. Devrimci-Özgüven H, Kundakçı N, Kumbasar H, Boyvat A (2000) The depression, anxiety, life satisfaction and affective expression levels in psoriasis patients. J Eur Acad Dermatol Venereol 14:267–271

    Article  PubMed  Google Scholar 

  9. Fredriksson T, Pettersson U (1978) Severe psoriasis—oral therapy with a new retinoid. Dermatologica 157:238–244

    Article  PubMed  CAS  Google Scholar 

  10. Kim JE, Park HJ (2011) Stress hormone and skin disease. In: Khopkar U (ed) Skin biopsy—perspectives. InTech, pp 209–224

  11. Kim JE, Cho DH, Kim HS et al (2007) Expression of the corticotropin-releasing hormone-proopiomelanocortin axis in the various clinical types of psoriasis. Exp Dermatol 16:104–109

    Article  PubMed  Google Scholar 

  12. Kishimoto T, Pearse RV 2nd, Lin CR, Rosenfeld MG (1995) A sauvagine/corticotropin-releasing factor receptor expressed in heart and skeletal muscle. Proc Natl Acad Sci USA 92:1108–1112

    Article  PubMed  CAS  Google Scholar 

  13. Kono M, Nagata H, Umemura S, Kawana S, Yoshiki Osamura R (2001) In situ expression of corticotropin-releasing hormone (CRH) and proopiomelanocortin (POMC) genes in human skin. FASEB J 15:2297–2299

    PubMed  CAS  Google Scholar 

  14. Liaw CW, Lovenberg TW, Barry G, Oltersdorf T, Grigoriadis DE, de Souza EB (1996) Cloning and characterization of the human corticotropin releasing factor-2 receptor complementary deoxyribonucleic acid. Endocrinology 137:72–77

    Article  PubMed  CAS  Google Scholar 

  15. O’Kane M, Murphy EP, Kirby B (2006) The role of corticotropin-releasing hormone in immune-mediated cutaneous inflammatory disease. Exp Dermatol 15:143–153

    Article  PubMed  Google Scholar 

  16. Perrin MH, Vale WW (1999) Corticotropin releasing factor receptors and their ligand family. Ann NY Acad Sci 885:312–328

    Article  PubMed  CAS  Google Scholar 

  17. Picardi A, Mazzotti E, Gaetano P et al (2005) Stress, social support, emotional regulation, and exacerbation of diffuse plaque psoriasis. Psychomatics 46:556–564

    Article  CAS  Google Scholar 

  18. Quevedo ME, Slominski A, Pinto W, Wei E, Wortsman J (2001) Pleiotropic effects of corticotropin releasing hormone on normal human skin keratinocytes. In Vitro Cell Dev Biol Anim 37:50–54

    Article  PubMed  CAS  Google Scholar 

  19. Singh LK, Boucher W, Pang X et al (1999) Potent mast cell degranulation and vascular permeability triggered by urocortin through activation of corticotropin-releasing hormone receptors. J Pharmacol Exp Ther 288:1349–1356

    PubMed  CAS  Google Scholar 

  20. Slominski A, Pisarchik A, Tobin DJ, Mazurkiewicz JE, Wortsman J (2004) Differential expression of a cutaneous corticotropin-releasing hormone system. Endocrinology 145:941–950

    Article  PubMed  CAS  Google Scholar 

  21. Slominski A, Wortsman J, Luger T et al (2000) Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress. Physiol Rev 80:979–1020

    PubMed  CAS  Google Scholar 

  22. Slominski AT, Botchkarev V, Choudhry M et al (1999) Cutaneous expression of CRH and CRH-R: is there a ‘skin stress response system?’. Ann NY Acad Sci 885:287–311

    Article  PubMed  CAS  Google Scholar 

  23. Slominski AT, Roloff B, Zbytek B et al (2000) Corticotropin releasing hormone and related peptides can act as bioregulatory factors in human keratinocytes. In Vitro Cell Dev Biol Anim 36:211–216

    Article  PubMed  CAS  Google Scholar 

  24. Suda T, Tomori N, Tozawa F, Mouri T, Demura H, Shizume K (1984) Distribution and characterization of immunoreactive corticotropin-releasing factor in human tissues. J Clin Endocrinol Metab 59:861–866

    Article  PubMed  CAS  Google Scholar 

  25. Tagen M, Stiles L, Kalogeromitros D et al (2007) Skin corticotropin-releasing hormone receptor expression in psoriasis. J Invest Dermatol 127:1789–1791

    PubMed  CAS  Google Scholar 

  26. Theoharides TC, Singh LK, Boucher W et al (1998) Corticotropin-releasing hormone induces skin mast cell degranulation and increased vascular permeability, a possible explanation for its proinflammatory effects. Endocrinology 139:403–413

    Article  PubMed  CAS  Google Scholar 

  27. Zbytek B, Mysliwski A, Slominski A et al (2002) Corticotropin-releasing hormone affects cytokine production in human HaCaT keratinocytes. Life Sci 70:1013–1021

    Article  PubMed  CAS  Google Scholar 

  28. Zbytek B, Pikula M, Slominski RM et al (2005) Corticotropin-releasing hormone triggers differentiation in HaCaT keratinocytes. Br J Dermatol 152:474–480

    Article  PubMed  CAS  Google Scholar 

  29. Zhou C, Yu X, Cai D, Liu C, Li C (2009) Role of corticotropin-releasing hormone and receptor in the pathogenesis of psoriasis. Med Hypotheses 73:513–515

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Dermatology, Ministry of Health Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey

    Bengü Çevirgen Cemil, Filiz Canpolat & Fatma Eskioğlu

  2. Department of Pathology (2nd), Ministry of Health Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey

    Demet Yılmazer & Murat Alper

Authors
  1. Bengü Çevirgen Cemil
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Filiz Canpolat
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Demet Yılmazer
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Fatma Eskioğlu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Murat Alper
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Bengü Çevirgen Cemil.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cemil, B.Ç., Canpolat, F., Yılmazer, D. et al. The association of PASI scores with CRH-R1 expression in patients with psoriasis. Arch Dermatol Res 304, 127–132 (2012). https://doi.org/10.1007/s00403-012-1218-4

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00403-012-1218-4

Keywords

Search

Navigation