Abstract
Previous studies have found conflicting results about the association of autoimmune blistering disease (AIBD) with cardiovascular disease (CVD) risk. The objective of the study was to systematically review the relationship of AIBD, including pemphigus vulgaris (PV), and its treatment with CVD and CVD risk factors. MEDLINE, EMBASE, Cochrane, LILACS, SCOPUS, and Web of Science were searched. We included all studies of CVD and CVD risk factors in AIBD patients. Two reviewers performed title and/or abstract review and data extraction. Pooled random-effects meta-analysis was performed. Forty papers met inclusion criteria. AIBD was associated with higher odds of diabetes (DM) (odds ratio [95% confidence interval]: 1.809 [1.258–2.601]), hypertension (HTN) (1.393 [1.088–1.784]), dyslipidemia (2.177 [1.163–4.073]) and heart failure (1.919 [1.603–2.298]), but was not associated with obesity, stroke, angina, heart attack, or arrhythmia. The pooled random-effects prevalence for treatment-related adverse events (AEs) in AIBD was 13.7% for DM, 10.7% for HTN, and 17.1% for CVD. Sensitivity analysis of high-quality studies revealed similar results. AIBD patients have increased CVD risk factors and heart failure. Systemic corticosteroid treatment results in CVD-related AEs in AIBD. Increased CVD screening and prevention strategies are warranted in AIBD.
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Abbreviations
- AE:
-
Adverse event
- AIBD:
-
Autoimmune blistering disease
- CI:
-
Confidence interval
- CVD:
-
Cardiovascular disease
- DM:
-
Diabetes mellitus
- HF:
-
Heart failure
- HTN:
-
Hypertension
- NOS:
-
Newcastle–Ottawa Scale
- OR:
-
Odds ratio
- PF:
-
Pemphigus foliaceous
- PV:
-
Pemphigus vulgaris
- TRAE:
-
Treatment-related adverse event
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JI Silverberg had full access to all the data in the study and takes responsibility for the integrity of the data and accuracy of the data analysis. Study concept and design: JIS. Acquisition of data: AAA, KW. Analysis and interpretation of data: AM, RA, JI Silverberg. Drafting of the manuscript: RA, AM, AA. Critical revision of manuscript for important intellectual content: JI Silverberg. Statistical analysis: RA, AM. Administrative technical or material support: none. Study supervision: none.
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Rokni, A.M., Ayasse, M., Ahmed, A. et al. Association of autoimmune blistering disease, and specifically, pemphigus vulgaris, with cardiovascular disease and its risk factors: a systematic review and meta-analysis. Arch Dermatol Res 315, 207–213 (2023). https://doi.org/10.1007/s00403-022-02346-y
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DOI: https://doi.org/10.1007/s00403-022-02346-y