Abstract
Case report
We report a pregnant patient with adenocarcinoma in situ (AIS) coexisting with carcinoma in situ (CIS) of the cervix diagnosed by conization at 16 weeks' gestation. Apoptotic activity was higher in the CIS lesion than in the AIS lesion in the cone biopsy specimen. Postpartum evaluation confirmed the disappearance of CIS lesion with positive cone margins, however, multifocal AIS with negative cone margins was found.
Conclusion
Clinical course and biological features of AIS associated with pregnancy may be different from those of CIS.
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References
Cook-Glenn CL, Keyhani-Rofagha S (1998) Adenocarcinoma of the uterine cervix associated with pregnancy: a retrospective 10-year investigative study. Diagn Cytopathol 18:393–397
Cullimore JE, Luesley DM, Rollason TP, Byrne P, Buckley CH, Anderson M, Williams DR, Waddell C, Hudson E, Shafi MI (1992) A prospective study of conization of the cervix in the management of cervical intraepithelial glandular neoplasia (CIGN): a preliminary report. Br J Obstet Gynaecol 99:314–318
Drew NC (1984) Adenocarcinoma-in-situ of the cervix uteri associated with cervical intraepithelial neoplasia in pregnancy. Case report. Br J Obstet Gynaecol 91:498–502
Edinger DD, Louis FJ (1982) Adenocarcinoma-in-situ of the endocervix with coexistent intrauterine pregnancy: report of a case and review of the literature. Clin Exp Obstet Gynecol 9:223–225
Fujiwaki R, Hata K, Iida K, Maede Y, Koike M, Miyazaki K (1999) Thymidine phosphorylase expression in progression of cervical cancer: correlation with microvessel count, proliferating cell nuclear antigen, and apoptosis. J Clin Pathol 52:598–603
Kiguchi K, Bibbo M, Hasegawa T, Kurihara S, Tsutsui F, Wied GL (1981) Dysplasia during pregnancy: a cytologic follow-up study. J Reprod Med 26:66–72
Matey DA, Gallup DG (1979) Adenocarcinoma in situ of the cervix during pregnancy. Obstet Gynecol 54:663–666
Muntz HG, Bell DA, Lage JM, Goff BA, Feldman S, Rice LW (1992) Adenocarcinoma in situ of the uterine cervix. Obstet Gynecol 80:935–939
Samaniego F, Bryant JL, Liu N, Karp JE, Sabichi AL, Thierry A, Lunardi-Iskandar Y, Gallo RC (1999) Induction of programmed cell death in Kaposi's sarcoma cells by preparations of human chorionic gonadotropin. J Natl Cancer Inst 91:135–143
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Nagaishi, M., Fujiwaki, R., Hata, K. et al. Adenocarcinoma in situ coexisting with carcinoma in situ of the cervix during pregnancy. Arch Gynecol Obstet 270, 116–118 (2004). https://doi.org/10.1007/s00404-002-0469-2
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DOI: https://doi.org/10.1007/s00404-002-0469-2