Abstract
Objective
To determine if women with less than five eggs retrieved do as well as women with more eggs retrieved in terms of pregnancy outcomes in our assisted reproduction program.
Method
Two hundred one women undergoing in vitro fertilization treatment at Fertility Unit in Royal Prince Alfred Hospital, University of Sydney, Australia were selected for retrospective evaluation. The women were grouped according to the number of oocytes retrieved at ovum pick-up. Group A consisted of women with less than 5 oocytes, group B with 5 to 10 oocytes and group C with 11 to 15 oocytes collected. Clinical and ongoing pregnancy rates were compared.
Results
There was no difference between the groups in terms of clinical and ongoing pregnancy rates.
Conclusion
With good IVF lab conditions, if a patient reaches embryo transfer, the number of eggs retrieved should not affect the likelihood of pregnancy outcome in an assisted reproductive technology treatment.
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References
Fasouliotis SJ, Simon A, Laufer N (2000) Evaluation and treatment of low responders in assisted reproductive technology: a challenge to meet. J Assist Reprod Genet 17:357–373
Tarlatzis BC, Zepiridis L, Grimbizis G, Bontis J (2003) Clinical management of low ovarian response to stimulation for IVF: a systematic review. Hum Reprod Update 9:61–76
Surrey ES, Schoolcraft WB (2000) Evaluating strategies for improving ovarian response of the poor responder undergoing assisted reproductive techniques. Fertil Steril 73:667–676
Mahutte NG, Arici A (2002) Poor responders: does the protocol make a difference? Curr Opin Obstet Gynecol 14:275–281
Serafini P, Stone B, Kerin J (1988) An alternative approach to controlled ovarian hyperstimulation in ‘poor responders’ with a gonadotrophin releasing hormone analog. Fertil Steril 49:90–95
Jenkins JM, Davies DW, Devonport H (1991) Comparison of ‘poor responders’ with ‘good responders’ using a standard buserelin/human menopausal gonadotrophin regime for in-vitro fertilisation. Hum Reprod 6:918–921
Land J, Yarmolinskaya M, Dumoulin J, Evers J (1996) High-dose human menopausal gonadotropin stimulation in poor responders does not improve in vitro fertilization outcome. Fertil Steril 65:961–965
Raga F, Bonilla-Musoles F, Casan EM, Bonilla F (1999) Recombinant follicle stimulating hormone stimulation in poor responders with normal basal concentrations of follicle stimulating hormone and oestradiol: improved reproductive outcome. Hum Reprod 14:1431–1434
Surrey ES, Bower JA, Hill DM, Ramsey J, Surrey MW (1998) Clinical and endocrine effects of a microdose GnRH agonist flare regimen administered to poor responders who are undergoing in vitro fertilization. Fertil Steril 69:419–424
Fenichel P, Grimaldi M, Olivero JF (1989) Predictive value of hormone profiles before stimulation for in vitro fertilization. Fertil Steril 51:845–849
Bancsi LF, Broekmans FJ, Eijkemans MJ, de Jong FH, Habbema JD, te Velde ER (2002) Predictors of poor ovarian response in in vitro fertilization: a prospective study comparing basal markers of ovarian reserve. Fertil Steril 77:328–336
Hendriks DJ, Mol BW, Bancsi LF, te Velde ER, Broekmans FJ (2005) Antral follicle count in the prediction of poor ovarian response and pregnancy after in vitro fertilization: a meta-analysis and comparison with basal follicle-stimulating hormone level. Fertil Steril 83:291–301
Mol BW, Verhagen TE, Hendriks DJ, Collins JA, Coomarasamy A, Opmeer BC (2006) Value of ovarian reserve testing before IVF: a clinical decision analysis. Hum Reprod 21:1816–1823
Farhi J, Homburg R, Ferber A (1997) Non-response to ovarian stimulation in normogonadotrophic, normogonadal women: a clinical sign of impending onset of ovarian failure pre-empting the rise in basal follicle stimulating hormone levels. Hum Reprod 12:241–243
Tanbo T, Dale PO, Lunde O (1992) Prediction of response to controlled ovarian hyperstimulation: a comparison of basal and clomiphene citrate-stimulated follicle-stimulating hormone levels. Fertil Steril 57:819–824
Winslow KL, Toner JP, Brzyski RG (1991) The gonadotrophin releasing hormone agonist stimulation test—a sensitive predictor of performance in the flare-up in vitro fertilization cycle. Fertil Steril 56:711–717
Franchin R, De Ziegler D, Olivennes F (1994) Exogenous follicle stimulating hormone ovarian reserve test (EFORT): a simple and reliable screening test for detecting ‘poor responders’ in in vitro fertilization. Hum Reprod 9:1607–1611
Smotrich DB, Widra EA, Gindoff PR (1995) Prognostic value of day 3 estradiol on in vitro fertilization outcome. Fertil Steril 64:1136–1140
Lass A, Skull J, McVeigh E (1997) Measurement of ovarian volume by transvaginal sonography before ovulation induction with human menopausal gonadotrophin for in-vitro fertilization can predict poor response. Hum Reprod 12:294–297
Tomas C, Nuojua-Huttunen S, Martikainen H (1997) Pretreatment transvaginal ultrasound examination predicts ovarian responsiveness to gonadotrophins in in-vitro fertilization. Hum Reprod 12:220–223
Zaidi J, Barber J, Kyei-Mensah A (1996) Relationship of ovarian stromal blood flow at the baseline ultrasound scan to subsequent follicular response in an in vitro fertilization program. Obstet Gynecol 88:779–784
Klinkert ER, Broekmans FJ, Looman CW, te Velde ER (2004) A poor response in the first in vitro fertilization cycle is not necessarily related to a poor prognosis in subsequent cycles. Fertil Steril 81:1247–1253
Kailasam C, Keay SD, Wilson P, Ford WCL, Jenkins JM (2004) Defining poor ovarian response during IVF cycles, in women aged <40 years, and its relationship with treatment outcome. Hum Reprod 19:1544–1547
Templeton A, Morris JK, Parslow W (1996) Factors that affect outcome of in-vitro fertilisation treatment. Lancet 348:1402–1406
Tarin JJ, Sampaio MC, Calatayud C, Castellvi RM, Bonilla-Musoles F, Pellicer A (1992) Relativity of the concept ‘high responder to gonadotrophins’. Hum Reprod 7:19–22
Devreker F, Pogonici E, De Maertelaer V, Revelard P, Van den Bergh M, Englert Y (1999) Selection of good embryos for transfer depends on embryo cohort size: implications for ‘mild ovarian stimulation’ debate. Hum Reprod 14:3002–3008
Gregory L (1998) Ovarian markers of implantation potential in assisted reproduction. Hum Reprod 13(Suppl 4):117–132
Lashen H, Ledger W, Lopez-Bernal A, Barlow D (1999) Poor responders to ovulation induction: is proceeding to in-vitro fertilization worthwhile? Hum Reprod 14:964–969
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Poor responders can achieve pregnancy if they succeed in embryo transfer.
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Yoldemir, T., Fraser, I.S. The effect of retrieved oocyte count on pregnancy outcomes in an assisted reproduction program. Arch Gynecol Obstet 281, 551–556 (2010). https://doi.org/10.1007/s00404-009-1221-y
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DOI: https://doi.org/10.1007/s00404-009-1221-y