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Digital 3D reconstruction of two parahissian accessory bundles in a case of Wolff-Parkinson-White syndrome

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Abstract

Three-dimensional reconstruction of digitized histological serial sections of the cardiac conduction system yielded two accessory pathways in a case of a 24-day-old male infant who died after a short period of illness with ECG findings of Wolff-Parkinson-White syndrome. In infants, the differential diagnosis of possible accessory pathways connecting the AV conduction system, atrial or ventricular septum includes dispersed conduction system tissue without connecting features. This is why three-dimensional reconstruction is necessary in order to refute or establish connectivity of cell groups as found in histological serial slice images.

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Acknowledgements

We would like to express our deep gratitude to Jakob Schneider, now at the Institute of Pathology at the University of Addis Ababa, Ethiopia, for preparing the tissue blocks and serial sections and making the tissue available for review. Work leading up to this study was supported by a grant of the Gebert Rüf Stiftung, Switzerland and by support of the Institute of Legal Medicine in Zürich to Dr. Schweitzer.

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Authors and Affiliations

  1. Abteilung Kardiologie, Klinik Schloss Mammern, 8265 , Mammern, Switzerland

    Christian Steffen

  2. Remote Sensing Laboratories, Institut für Geographie der Universität Zürich, 8057, Zürich, Switzerland

    Michael Schaepman

  3. 8400, Winterthur, Switzerland

    Thomas Hardmeier

  4. Institut für Rechtsmedizin der Universität Zürich, Winterthurerstrasse 190 Bau 52, 8057, Zürich, Switzerland

    Wolf Schweitzer

Authors
  1. Christian Steffen
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  2. Michael Schaepman
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  3. Thomas Hardmeier
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  4. Wolf Schweitzer
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Corresponding author

Correspondence to Wolf Schweitzer.

Additional information

C. Steffen and W. Schweitzer contributed equally to this study.

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Steffen, C., Schaepman, M., Hardmeier, T. et al. Digital 3D reconstruction of two parahissian accessory bundles in a case of Wolff-Parkinson-White syndrome. Int J Legal Med 118, 101–105 (2004). https://doi.org/10.1007/s00414-003-0417-0

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  • DOI: https://doi.org/10.1007/s00414-003-0417-0

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