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Population genetic analysis of a 21-plex DIP panel in seven Chinese ethnic populations

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26 February 2020 ‘Concerns have been raised about the ethics approval and informed consent procedures related to the research reported in this paper. The paper includes the following author declarations:“Four hundred and fifty samples were collected with informed consent from the donors”“All procedures performed in this study involving human participants were in accordance with the ethical standards of the Ethics Committee of Sichuan University, China.”Editorial action will be taken as appropriate once an investigation of the concerns is complete and all parties have been given an opportunity to respond in full.’

Abstract

A 21-plex DIP (deletion and insertion polymorphism) panel has a good performance in analyzing biogeographic ancestry in three main global population groups (European, African, and Asian). This panel was used to investigate 450 unrelated individuals in seven Chinese ethnic groups (Han, Dong, Miao, Zhuang, Uyghur, Tibetan, and Mongolian). Allele frequencies were calculated. Mho (mean value of observed heterozygosity) ranged from 0.3019 to 0.4367, MHe (mean value of expected heterozygosity) ranged from 0.31175 to 0.38341, CMP (combined matching probability) ranged from 3.5834E-07 to 2.5985E-06, CDP (combined power of discrimination) ranged from 0.99999740150 to 0.99999964166, and CPE (combined power of paternity exclusion) ranged from 0.85884504 to 0.97949131. The results suggested the potential of the panel for individual identification and paternity testing in Chinese populations. Pairwise genetic differences Fst values (−0.00091 to 0.05873) and the analysis by STRUCTURE indicated that Chinese populations have good internal consistency.

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  • 26 February 2020

    ‘Concerns have been raised about the ethics approval and informed consent procedures related to the research reported in this paper. The paper includes the following author declarations:

    “Four hundred and fifty samples were collected with informed consent from the donors”

    “All procedures performed in this study involving human participants were in accordance with the ethical standards of the Ethics Committee of Sichuan University, China.”

    Editorial action will be taken as appropriate once an investigation of the concerns is complete and all parties have been given an opportunity to respond in full.’

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Acknowledgements

This work was supported by Grants from the National Natural Science Foundation of China (No. 81671871), and the authors would like to thank all contributors who participate to the study.

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Authors and Affiliations

  1. Department of Forensic Genetics, West China School of Basic Sciences and Forensic Medicine, Sichuan University, Chengdu, Sichuan, 610041, China

    Youjing Jiang, Jienan Li, Weibo Liang & Lin Zhang

  2. Department of Forensic Medicine, Sichuan Police College, Luzhou, Sichuan, 646000, China

    Wang He

  3. Department of Forensic Genetics, Chengdu Public Security Bureau, Institute of Forensic Science, Chengdu, Sichuan, 610081, China

    Hui Wang, Dan Chen & Xiaogang Bai

  4. Laboratory of Molecular Translational Medicine, West China Institute of Women and Children’s Health, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, China

    Lin Zhang

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  1. Youjing Jiang
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  8. Lin Zhang
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Corresponding authors

Correspondence to Weibo Liang or Lin Zhang.

Ethics declarations

All procedures performed in this study involving human participants were in accordance with the ethical standards of the Ethics Committee of Sichuan University, China.

Conflict of interest

The authors declare that they have no conflict of interest.

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Jiang, Y., He, W., Wang, H. et al. Population genetic analysis of a 21-plex DIP panel in seven Chinese ethnic populations. Int J Legal Med 132, 145–147 (2018). https://doi.org/10.1007/s00414-017-1639-x

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  • DOI: https://doi.org/10.1007/s00414-017-1639-x

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