Abstract.
Posterior reversible encephalopathy syndrome (PRES) is a leukoencephalopathy clinically characterized by headache, altered mental status, visual loss and seizures. Neuroimaging demonstrates symmetrical posterior cortical and subcortical lesions. The exact pathophysiology is unknown but there is a strong association with immunosuppressants and hypertension. We report two cases of PRES in normotensive patients with severe hypercalcemia as the only identifiable cause. Possible pathophysiological mechanisms are discussed.
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Received: 20 March 2002, Received in revised form: 22 May 2002, Accepted: 4 June 2002
Correspondence to Dr. Oliver Kastrup
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Kastrup, O., Maschke, M., Wanke, I. et al. Posterior reversible encephalopathy syndrome due to severe hypercalcemia. J Neurol 249, 1563–1566 (2002). https://doi.org/10.1007/s00415-002-0895-x
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DOI: https://doi.org/10.1007/s00415-002-0895-x