Abstract
Objective
An isolated dysfunction of the blood–CSF barrier is characterised by an abnormal elevation of the albumin CSF/serum concentration ratio (Qalb) without any other pathological CSF findings. Although common in routine CSF analysis, the clinical significance of an isolated barrier dysfunction frequently remains unclear. We examined neurological disorders associated with an isolated elevation of Qalb to identify possible determinants of blood–CSF barrier dysfunction.
Methods
367 patients (124 women, 243 men, median age 60. 0 years) out of 3873 patients receiving diagnostic lumbar puncture at the University Hospital of Ulm (Germany) showed an isolated dysfunction of the blood–CSF barrier. Clinical data as well as MRI findings of these patients were analysed.
Results
Isolated barrier dysfunction occurred most frequently (> 30%) in Guillain–Barré syndrome (GBS), chronic inflammatory demyelinating polyneuropathy (CIDP), normal pressure hydrocephalus (NPH), lumbar spinal stenosis, and polyneuropathy (PNP). In patients who showed no other evidence of neurological disease, isolated barrier dysfunction was found in 14. 9% of cases. The extent of barrier dysfunction was most prominent in brain tumours, GBS, and CIDP. There was a significant correlation of Qalb with both weight and body mass index (BMI).
Conclusions
Although isolated barrier dysfunction may be found in a variety of neurological diseases, it is especially frequent in GBS, CIDP, NPH, spinal canal stenosis, and PNP. In these patients, disease–related mechanisms contributing to barrier dysfunction are likely. Moreover, barrier function seems to be influenced by disease–independent determinants like weight and BMI.
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Brettschneider, J., Claus, A., Kassubek, J. et al. Isolated blood–cerebrospinal fluid barrier dysfunction: prevalence and associated diseases. J Neurol 252, 1067–1073 (2005). https://doi.org/10.1007/s00415-005-0817-9
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DOI: https://doi.org/10.1007/s00415-005-0817-9