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Epiretinal proliferation in lamellar macular holes and full-thickness macular holes: clinical and surgical findings

  • Retinal Disorders
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An Erratum to this article was published on 25 September 2015

Abstract

Purpose

To report the clinical findings and surgical outcomes of lamellar macular holes (LMH) with or without lamellar hole-associated epiretinal proliferation (LHEP), and those of full-thickness macular holes (FTMH) presenting with LHEP.

Methods

From 2009 to 2013, consecutive cases of surgically treated LMH, and all FTMH cases with LHEP were reviewed, given a follow-up time over 1 year.

Results

In the LMH group (43 cases), those with LHEP (19 cases) had significantly thinner bases and larger openings than those without (24 cases). The rate of disrupted IS/OS line was higher in the LHEP subgroup preoperatively (68.4 % vs 37.5 %), but similar between subgroups postoperatively (36.8 % and 33.3 %). The preoperative and postoperative visual acuity showed no significant difference between two subgroups. In the FTMH group (13 cases), the average hole size was 219.2 ± 92.1 μm. Permanent or transient spontaneous hole closure was noted in 69.2 % of cases. An intact IS-OS line was found in only 23 % of cases at the final follow-up.

Conclusion

In the LMH group, LHEP was associated with a more severe defect but didn’t affect surgical outcomes. In the FTMH group, spontaneous hole closure was frequently noted. Despite small holes, disruption of IS-OS line was common after hole closure.

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References

  1. Gass JDM (1976) Lamellar macular hole: a complication of cystoid macular edema after cataract extraction. Arch Ophthalmol 94:793–800

    Article  CAS  PubMed  Google Scholar 

  2. Witkin AJ, Ko TH, Fujimoto JG, Schuman JS, Baumal CR, Rogers AH, Reichel E, Duker JS (2006) Redefining lamellar holes and the vitreomacular interface: an ultrahigh-resolution optical coherence tomography study. Ophthalmology 113:388–397

    Article  PubMed  PubMed Central  Google Scholar 

  3. Parolini B, Schumann RG, Cereda MG, Haritoglou C, Pertile G (2011) Lamellar macular hole: a clinicopathologic correlation of surgically excised epiretinal membranes. Invest Ophthalmol Vis Sci 52:9074–9083. doi:10.1167/iovs.11-8227

    Article  PubMed  Google Scholar 

  4. Pang CE, Spaide RF, Freund KB (2014) Epiretinal proliferation seen in association with lamellar macular holes: a distinct clinical entity. Retina 34:1513–1523

    Article  PubMed  Google Scholar 

  5. Schumann RG, Compera D, Schaumberger MM, Wolf A, Fazekas C, Mayer WJ, Kampik A, Haritoglou C (2015) Epiretinal membrane characteristics correlate with photoreceptor layer defects in lamellar macular holes and macular pseudoholes. Retina 35:727–735. doi:10.1097/IAE.0000000000000375

    Article  PubMed  Google Scholar 

  6. Duker JS, Kaiser PK, Binder S, de Smet MD, Gaudric A, Reichel E, Sadda SR, Sebag J, Spaide RF, Stalmans P (2013) The International Vitreomacular Traction Study Group classification of vitreomacular adhesion, traction, and macular hole. Ophthalmology 120:2611–2619. doi:10.1016/j.ophtha.2013.07.042

    Article  PubMed  Google Scholar 

  7. Sun JP, Chen SN, Chuang CC, Lin CW, Lin CJ, Huang JY, Yang CM, Chen MS, Yang CH (2013) Surgical treatment of lamellar macular hole secondary to epiretinal membrane. Graefes Arch Clin Exp Ophthalmol 251:2681–2688. doi:10.1007/s00417-013-2364-x

    Article  PubMed  Google Scholar 

  8. Kao TY, Yang CM, Yeh PT, Huang JY, Yang CH (2013) The value of combining autofluorescence and optical coherence tomography in predicting the visual prognosis of sealed macular holes. Am J Ophthalmol 156(149–156), e141. doi:10.1016/j.ajo.2013.02.005

    Google Scholar 

  9. Pang CE, Spaide RF, Freund KB (2015) Comparing functional and morphologic characteristics of lamellar macular holes with and without lamellar hole-associated epiretinal proliferation. Retina 35:720–726. doi:10.1097/IAE.0000000000000390

    Article  PubMed  Google Scholar 

  10. Takahashi H, Kishi S (2000) Tomographic features of a lamellar macular hole formation and a lamellar hole that progressed to a full-thickness macular hole. Am J Ophthalmol 130:677–679

    Article  CAS  PubMed  Google Scholar 

  11. Shiraga F, Takasu I, Fukuda K, Fujita T, Yamashita A, Hirooka K, Shirakata Y, Morizane Y, Fujiwara A (2013) Modified vitreous surgery for symptomatic lamellar macular hole with epiretinal membrane containing macular pigment. Retina 33:1263–1269. doi:10.1097/IAE.0b013e31828bcb61

    Article  PubMed  Google Scholar 

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Conflict of interest statement

All authors certify that they have NO affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge, or beliefs) in the subject matter or materials discussed in this manuscript.

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Authors and Affiliations

  1. Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan

    Tso-Ting Lai & Chung-May Yang

  2. Department of Ophthalmology, Changhua Christian Hospital, Changhua, Taiwan

    San-Ni Chen

  3. Department of Medicine, Chung-Shan Medical University, Taichung, Taiwan

    San-Ni Chen

  4. Department of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

    San-Ni Chen

  5. College of Medicine, National Taiwan University, Taipei, Taiwan

    Chung-May Yang

Authors
  1. Tso-Ting Lai
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  2. San-Ni Chen
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  3. Chung-May Yang
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Correspondence to Chung-May Yang.

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Lai, TT., Chen, SN. & Yang, CM. Epiretinal proliferation in lamellar macular holes and full-thickness macular holes: clinical and surgical findings. Graefes Arch Clin Exp Ophthalmol 254, 629–638 (2016). https://doi.org/10.1007/s00417-015-3133-9

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  • DOI: https://doi.org/10.1007/s00417-015-3133-9

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