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Investigating the ocular temperature rise during femtosecond laser lens fragmentation: an in vitro study

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Abstract

Purpose

To investigate the trend of temperature variation during lens fragmentation simulated by a femtosecond laser on an in vitro eye model.

Methods

In our experimental study, a convex cylinder of gelatinous material, usually employed in femtosecond laser calibration, was used to simulate both an anterior segment and a crystalline lens during fragmentation performed with the Victus femtosecond laser (Technolas Perfect Vision GmbH, Germany; Bausch + Lomb Incorporated, USA). Two radiated energies (7000 nJ and 9000 nJ) and three cutting patterns (crosses, circles and cross + circle) were applied. Trends of temperature variation as a function of time were obtained using a T-type thermocouple.

Results

The maximum value of temperature rise during lens fragmentation ranged from 3.53 to 5.13 °C; the rise was directly proportional to the intensity of the radiated energy (7000 nJ or 9000 nJ) and the cutting pattern performed. This behavior was experimentally represented by an asymmetric function with a characteristic bell curve shape, whereas it was mathematically described by a transport diffusive model.

Conclusions

Since the temperature rise at the fragmentation volume base resulted to be around 5 °C in our in vitro study, lens fragmentation performed using the Victus femtosecond laser might be considered safe form a thermal point of view.

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Acknowledgments

The authors wish to thank Professor F. Fanelli for enlightenment on diffusion model in biological systems and Professor S. Ruffo for the support in mathematical analysis.

No public or private financial support was received for the study.

Author information

Authors and Affiliations

  1. Department of Surgery and Translational Medicine, Eye Clinic, University of Florence, Largo Brambilla 3, 50134, Florence, Italy

    Rita Mencucci, Luca Terracciano & Eleonora Favuzza

  2. Department of Industrial Engineering, University of Florence, Florence, Italy

    Sara Matteoli & Andrea Corvi

  3. INFN, CSDC, Department of Information Engineering, University of Florence, Florence, Italy

    Stefano Gherardini

  4. QSTAR, LENS, Department of Physics and Astronomy, University of Florence, Florence, Italy

    Filippo Caruso

  5. Ophthalmic Unit, University Hospital, Verona, Italy

    Roberto Bellucci

Authors
  1. Rita Mencucci
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  2. Sara Matteoli
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  3. Andrea Corvi
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  4. Luca Terracciano
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  5. Eleonora Favuzza
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  6. Stefano Gherardini
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  7. Filippo Caruso
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  8. Roberto Bellucci
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Corresponding author

Correspondence to Rita Mencucci.

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The authors declare that they have no conflict of interest.

All authors certify that they have NO affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Mencucci, R., Matteoli, S., Corvi, A. et al. Investigating the ocular temperature rise during femtosecond laser lens fragmentation: an in vitro study. Graefes Arch Clin Exp Ophthalmol 253, 2203–2210 (2015). https://doi.org/10.1007/s00417-015-3196-7

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  • DOI: https://doi.org/10.1007/s00417-015-3196-7

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