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Different foveal schisis patterns in each retinal layer in eyes with hereditary juvenile retinoschisis evaluated by en-face optical coherence tomography

  • Retinal Disorders
  • Published:
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Abstract

Purpose

To analyze the structures of schisis in eyes with hereditary juvenile retinoschisis using en-face optical coherence tomography (OCT) imaging.

Methods

In this retrospective observational study, we reviewed the medical records of patients with hereditary juvenile retinoschisis who underwent comprehensive ophthalmic examinations including swept-source OCT.

Results

OCT images were obtained from 16 eyes of nine boys (mean age ± standard deviation, 10.6 ± 4.0 years). The horizontal OCT images at the fovea showed inner nuclear layer (INL) schisis in one eye (6.3 %), ganglion cell layer (GCL) and INL schisis in 12 eyes (75.0 %), INL and outer plexiform layer (OPL) schisis in two eyes (12.5 %), and GCL, INL, and OPL schisis in one eye (6.3 %). En-face OCT images showed characteristic schisis patterns in each retinal layer, which were represented by multiple hyporeflective holes in the parafoveal region in the GCL, a spoke-like pattern in the foveal region, a reticular pattern in the parafoveal region in the INL, and multiple hyporeflective polygonal cavities with partitions in the OPL.

Conclusions

Our results using en-face OCT imaging clarified different patterns of schisis formation among the GCL, INL, and OPL, which lead to further recognition of structure in hereditary juvenile retinoschisis.

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Acknowledgments

We thank the patients for participating in this study. This work was supported by grants from the Ministry of Health, Labour, and Welfare (H24-Nanchi-Ippan-031) and the National Centre for Child Health and Development 25-7.

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Authors and Affiliations

  1. Department of Ophthalmology and Laboratory for Visual Science, National Center for Child Health and Development, 2-10-1 Okura Setagaya-ku, Tokyo, 157-8535, Japan

    Tomoyo Yoshida-Uemura, Satoshi Katagiri, Tadashi Yokoi, Sachiko Nishina & Noriyuki Azuma

  2. Department of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan

    Satoshi Katagiri

Authors
  1. Tomoyo Yoshida-Uemura
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  2. Satoshi Katagiri
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  3. Tadashi Yokoi
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  4. Sachiko Nishina
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  5. Noriyuki Azuma
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Corresponding author

Correspondence to Noriyuki Azuma.

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Conflict of interest

All authors certify that they have no affiliations or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript.

Ethical approval

The Institutional Review Board of the National Center for Child Health and Development approved this retrospective observational case series, which adhered to the tenets of the Declaration of Helsinki.

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Supplementary Fig. 1

Pairs of horizontal optical coherence tomography (OCT) images of each retinal layer from 512 A-scans × 256 B-scans in a 3 × 3-millimeter square. a A randomly selected pair of upper and lower horizontal OCT images corresponding to the holes in the ganglion cell layer (GCL) on en-face OCT clearly show several schisis cavities in the GCL, while the B-scan images do not detect a round expanding schisis cavity (right eye of case 5). b A randomly selected pair of upper and lower horizontal OCT images corresponding to the reticular pattern in the inner nuclear layer (INL) on en-face OCT show similar structures (right eye of case 3). c A randomly selected pair of upper and lower horizontal OCT images corresponding to a spoke-wheel pattern in the INL on en-face OCT show similar structures (right eye of case 6). d A randomly selected pair of upper and lower horizontal OCT images corresponding to polygonal hyporeflective cavities with hyperreflective partitions in the outer plexiform layer on en-face OCT show similar structures (right eye of case 8). a–d In each column, yellow dashed lines in the upper panels indicate the position at which the B-scan images in the middle and the lower panels are obtained. The orange arrows in the upper panels indicating the cavity in each en-face OCT image correspond to the orange arrows in the middle panels indicating the cavity in each B-scan image. The yellow arrows in the upper panels indicating the cavity in each en-face OCT image correspond to the yellow arrows in the lower panels indicating the cavity in each B-scan image. (GIF 99 kb)

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Yoshida-Uemura, T., Katagiri, S., Yokoi, T. et al. Different foveal schisis patterns in each retinal layer in eyes with hereditary juvenile retinoschisis evaluated by en-face optical coherence tomography. Graefes Arch Clin Exp Ophthalmol 255, 719–723 (2017). https://doi.org/10.1007/s00417-016-3552-2

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  • DOI: https://doi.org/10.1007/s00417-016-3552-2

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