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Regulation of TRP channels by PIP2

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Abstract

Transient receptor potential (TRP) channels are regulated by a wide variety of physical and chemical factors. Recently, several members of the TRP channel family were reported to be regulated by phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2, PIP2). This review will summarize the current knowledge on PIP2 regulation of TRP channels and discuss the possibility that PIP2 is a common regulator of mammalian TRP channels.

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Acknowledgements

The insightful comments of Dr. John Reeves are highly appreciated. The author is also indebted to the financial support of the American Heart Association, the Alexander and Alexandrine Sinsheimer Foundation and the UMDNJ Foundation.

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  1. Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, NJ, 07103, USA

    Tibor Rohacs

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Rohacs, T. Regulation of TRP channels by PIP2 . Pflugers Arch - Eur J Physiol 453, 753–762 (2007). https://doi.org/10.1007/s00424-006-0153-7

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