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Mucin core protein expression in serrated polyps of the large intestine

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Abstract

Sessile serrated adenoma (SSA) has been proposed as a precursor to microsatellite-unstable colorectal carcinoma. However, histological criteria dictating how to differentiate serrated lesions have not been completely established, and a histological overlap exists between SSA and hyperplastic polyps (HPs), particularly the microvesicular type. In this study, based on a critical review of histology, we aimed to elucidate the potential utility of the mucin phenotype in the identification of SSA. We evaluated mucin core protein expression (MUC2, MUC5AC, and MUC6) by immunohistochemical stain in 65 cases of microvesicular-type HPs, 51 SSAs, and 72 traditional serrated adenomas (TSAs). SSAs had clinicopathological and morphological features distinct from those of HPs and TSAs. MUC6 was more frequently positive in SSAs (39%) than in TSAs (4%) and HPs (19%) (P < 0.001 and P = 0.0107, respectively). Right-sided HPs more frequently expressed MUC6 than did left-sided HPs (60% vs. 4%, respectively; P < 0.0001), but SSAs and TSAs showed no regional differences. These findings suggest that determination of mucin core protein expression is insufficient for differentiating SSAs from other types of serrated polyps, and that microvesicular-type HPs of the right colon and SSAs may belong to the same mucin spectrum.

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Acknowledgments

The authors thank Ms Y. Nozuka for technical assistance. The English in this manuscript was edited by Edanz.

Conflict of interest statement

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan

    Kohei Fujita, Minako Hirahashi, Hidetaka Yamamoto, Masaki Gushima, Yoshinao Oda & Masazumi Tsuneyoshi

  2. Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Kohei Fujita, Takayuki Matsumoto, Masaki Gushima & Mitsuo Iida

  3. Department of Digital Medicine Initiative, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Junji Kishimoto

  4. Department of Human Pathology, Juntendo University School of Medicine, Tokyo, Japan

    Takashi Yao

Authors
  1. Kohei Fujita
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  2. Minako Hirahashi
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  3. Hidetaka Yamamoto
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  4. Takayuki Matsumoto
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  5. Masaki Gushima
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  6. Yoshinao Oda
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  7. Junji Kishimoto
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  8. Takashi Yao
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  9. Mitsuo Iida
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  10. Masazumi Tsuneyoshi
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Corresponding author

Correspondence to Minako Hirahashi.

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Fujita, K., Hirahashi, M., Yamamoto, H. et al. Mucin core protein expression in serrated polyps of the large intestine. Virchows Arch 457, 443–449 (2010). https://doi.org/10.1007/s00428-010-0959-8

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  • DOI: https://doi.org/10.1007/s00428-010-0959-8

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