Abstract
Renal cell carcinomas (RCC) are well-vascularized tumors. Although clear cell RCC (CCRCC) show a characteristic vascular network, some cases show overlapping features with other RCC. We aimed to evaluate vascular architectural patterns, microvessel density (MVD), and endothelial cell density (ECD) in CCRCC compared to clear cell papillary RCC (ccpRCC). Thirty-four RCC (17 CCRCC and 17 ccpRCC) were included in the study. CD34 was used to evaluate vascular architectural patterns by microscopic estimation in all cases. CD34, ERG, and Bioquant Osteo 2019 Imaging Analysis Software were used to evaluate MVD and ECD in 17 CCRCC and 15 ccpRCC. Mean MVD was 526.63 in CCRCC vs. 426.18 in ccpRCC (p = 0.16); mean ECD was 937.50 in CCRCC vs. 1060.21 in ccpRCC (p = 0.25). CD34 highlighted four distinct vascular architectural patterns: pseudoacinar, Golgi-like, lacunae, and scattered. Lacunae and pseudoacinar was the most frequent combination in CCRCC; lacunae and Golgi-like was the predominant combination among ccpRCC. Pseudoacinar was most extensive in CCRCC and least in ccpRCC; Golgi-like was predominant in ccpRCC and uncommon in CCRCC. The extent of pseudoacinar and Golgi-like vascular architectural patterns was significantly different between CCRCC and ccpRCC (p < 0.05). Pathologists acquainted with these different vascular architectural patterns may utilize them as an additional tool in the distinction of CCRCC from ccpRCC.
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17 October 2021
The citation of the author name Maria del Carmen Rodriguez Pena has been updated.
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S. C.-P. conceived of the study, formulated its design, coordinated the conduct of the study including data collection, performed the statistical analysis and interpreted the data, and drafted the manuscript; C. M.-G. participated in the design of the study, assisted in interpreting the data, and helped to draft the manuscript; M. C. R. P. participated in the design of the study, assisted in interpreting the data, and helped to draft the manuscript; D. W. coordinated the conduct of the study including data collection; D. F. S. performed the statistical analysis and interpreted the data; G. J. N. reviewed and edited the manuscript. All authors read and approved the final manuscript.
This study was approved by the university human research ethics committee, and all procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
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Canete-Portillo, S., Rodriguez Pena, M.d.C., Wang, D. et al. Vascular architectural patterns in clear cell renal cell carcinoma and clear cell papillary renal cell carcinoma. Virchows Arch 479, 1187–1196 (2021). https://doi.org/10.1007/s00428-021-03214-2
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DOI: https://doi.org/10.1007/s00428-021-03214-2