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Mean diffusivity of basal ganglia and thalamus specifically associated with motivational states among mood states

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Abstract

Previously, we proposed that the mean diffusivity (MD), a measure of diffusion tensor imaging (DTI) in areas of the dopaminergic system (MDDS), is associated with motivation. In this study, we tested if and how the motivational state is associated with MD in comparison with other mood states. We also tested the associations of these mood states with multiple cognitive functions. We examined these issues in 766 right-handed healthy young adults. We employed analyses of MD and a psychological measure of the profile of mood states (POMS) as well as multiple cognitive functions. We detected associations between the higher Vigor subscale of POMS and lower MD in the right globus pallidum, right putamen to right posterior insula, right caudate body, and right thalamus, and these associations were highly specific to the Vigor subscale. Similarly, the association of the motivational state with creativity measured by divergent thinking (CMDT) was rather specific and prominent compared with that of the other mood states and cognitive functions. In conclusion, when affective states are finely divided, only the motivational state is associated with MD in the areas related to the dopaminergic system, and psychological mechanisms that had been associated with dopaminergic system (CMDT). These results suggest that these mechanisms specifically contribute to the motivational state and not to the other states, such as depression and anxiety.

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Acknowledgments

We respectfully thank Yuki Yamada for operating the MRI scanner, Yuriko Suzuki from Philips for advice on the DWI and Haruka Nouchi for being an examiner of psychological tests. We also thank study participants, the other examiners of psychological tests, and all of our colleagues in Institute of Development, Aging and Cancer and in Tohoku University for their support. This study was supported by a Grant-in-Aid for Young Scientists (B) (KAKENHI 23700306) and a Grant-in-Aid for Young Scientists (A) (KAKENHI 25700012) from the Ministry of Education, Culture, Sports, Science, and Technology. The authors would like to thank Enago (http://www.enago.jp) for the English language review.

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Authors and Affiliations

  1. Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, Sendai, 980-8575, Japan

    Hikaru Takeuchi, Yasuyuki Taki, Yuko Sassa & Ryuta Kawashima

  2. Division of Medical Neuroimaging Analysis, Department of Community Medical Supports, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan

    Yasuyuki Taki & Atsushi Sekiguchi

  3. Department of Radiology and Nuclear Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan

    Yasuyuki Taki

  4. Department of Functional Brain Imaging, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan

    Atsushi Sekiguchi, Seishu Nakagawa, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa & Ryuta Kawashima

  5. Human and Social Response Research Division, International Research Institute of Disaster Science, Tohoku University, Sendai, Japan

    Rui Nouchi

  6. Division of Clinical research, Medical-Industry Translational Research Center, Fukushima Medical University, School of Medicine, Fukushima, Japan

    Yuka Kotozaki & Ryuta Kawashima

  7. Department of General Systems Studies, Graduate School of Arts and Sciences, The University of Tokyo, Bunkyo, Tokyo, Japan

    Carlos Makoto Miyauchi

  8. Japan Society for the Promotion of Science, Tokyo, Japan

    Ryoichi Yokoyama

  9. Smart Aging International Research Center, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan

    Tsuyoshi Araki

  10. Faculty of Medicine, Tohoku University, Sendai, Japan

    Keiko Kunitoki

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  1. Hikaru Takeuchi
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  2. Yasuyuki Taki
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  3. Atsushi Sekiguchi
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  4. Rui Nouchi
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  10. Takamitsu Shinada
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Correspondence to Hikaru Takeuchi.

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Takeuchi, H., Taki, Y., Sekiguchi, A. et al. Mean diffusivity of basal ganglia and thalamus specifically associated with motivational states among mood states. Brain Struct Funct 222, 1027–1037 (2017). https://doi.org/10.1007/s00429-016-1262-5

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  • DOI: https://doi.org/10.1007/s00429-016-1262-5

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