Abstract
B cells were previously shown to mediate partial protection against CMV infection, as in the absence of B cells, latently infected mice were more susceptible to virus reactivation. It remains unclear if this effect stems from the loss of B cells as antibody producers or as antigen presenting cells. To address this fundamental question, we propose to make use of new mouse models that allow conditional ablation of B cells or that allow for the generation of mice with B cells that are not able to produce antibodies.
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Acknowledgment
This work was funded by the Deutsche Forschungsgemeinschaft grant SFB490 (TPE8) and FP6 Marie Curie Research Training Network MRTN-CT-2004-005632 (IMDEMI).
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Waisman, A., Croxford, A.L. & Demircik, F. New tools to study the role of B cells in cytomegalovirus infections. Med Microbiol Immunol 197, 145–149 (2008). https://doi.org/10.1007/s00430-008-0088-z
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DOI: https://doi.org/10.1007/s00430-008-0088-z