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The potential of recombinant antigens ESAT-6, MPT63 and mig for specific discrimination of Mycobacterium tuberculosis and M. avium infection

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Fig. 1.

References

  1. Andersen P, Munk M, Pollok J, Doherty T (2000) Specific immune-based diagnosis of tuberculosis. Lancet 356: 1099–1104

    Article  CAS  PubMed  Google Scholar 

  2. Lein AD, von Reyn CF, Ravn P, Horsburgh CRJ, Alexander LN, Andersen P (1999) Cellular immune responses to ESAT-6 discriminate between patients with pulmonary disease due to Mycobacterium avium complex and those with pulmonary disease due to Mycobacterium tuberculosis. Clin Diagn Lab Immunol 6: 606–609

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Lyashchenko K, Colangeli R, Houde M, Al Jahdali H, Menzies D, Gennaro ML (1998) Heterogeneous antibody responses in tuberculosis. Infect Immun 66: 3936–3940

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Lyashchenko K, Manca C, Colangeli R, Heijbel A, Williams A, Gennaro ML (1998) Use of Mycobacterium tuberculosis complex-specific antigen cocktails for a skin test specific for tuberculosis. Infect Immun 66: 3606–3610

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Plum G, Brenden M, Santos P, Schwarz E, Wahnschaffe U, Mauff G, Pulverer G (1996) Serum antibody reactivity to recombinant mig and whole cell antigens in Mycobacterium avium infection. Zbl Bakt 284: 348–360

    Article  CAS  Google Scholar 

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Acknowledgements

We thank Gabi Schulz, Margret Oberreit and Petra Ellensohn for technical assistance and are grateful to Andreas Roth and Harald Mauch, Institute for Microbiology, Chest Hospital Heckeshorn, Berlin and the colleagues from Fachkliniken Wangen (Wangen), Johanniter-Hospital (Treuenbrietzen), St. Joseph's-Hospital, Children's Hospital Neukölln and Lindenhof (Berlin), Children's University Hospitals of Bochum and Frankfurt/Main, Altonaer Children's Hospital (Hamburg), Elisabeth-Hospital (Oldenburg), Children's Hospital (Wismar), and Horst-Schmidt-Hospital (Wiesbaden) for patient inclusion. This work was supported by the German Ministry of Education and Research (Grant No. FKZ-01KI9712).

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Authors and Affiliations

  1. Department of Paediatric Pneumology and Immunology, Charité, Humboldt University, Augustenburger Platz 1, 13353 , Berlin, Germany

    Claudia Rolinck-Werninghaus, Klaus Magdorf & Ulrich Wahn

  2. Robert-Koch-Institute, Berlin, Germany

    Klaus Stark

  3. Chembio Diagnostic Systems, Medford, USA

    Konstantin Lyashchenko

  4. Public Health Research Institute, Newark, USA

    Maria Laura Gennaro

  5. Montefiore Medical Centre, New York, USA

    Roberto Colangeli

  6. Statens Seruminstitut, Copenhagen, Denmark

    T. Mark Doherty & Peter Andersen

  7. Institute of Medical Microbiology and Hygiene, Cologne, Germany

    Georg Plum

  8. Department of Clinical Chemistry and Molecular Diagnostics, University of Marburg, Marburg, Germany

    Udo Herz & Harald Renz

Authors
  1. Claudia Rolinck-Werninghaus
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  2. Klaus Magdorf
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  3. Klaus Stark
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  4. Konstantin Lyashchenko
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  5. Maria Laura Gennaro
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  6. Roberto Colangeli
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  7. T. Mark Doherty
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  8. Peter Andersen
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  9. Georg Plum
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  10. Udo Herz
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  11. Harald Renz
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  12. Ulrich Wahn
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Corresponding author

Correspondence to Claudia Rolinck-Werninghaus.

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Rolinck-Werninghaus, C., Magdorf, K., Stark, K. et al. The potential of recombinant antigens ESAT-6, MPT63 and mig for specific discrimination of Mycobacterium tuberculosis and M. avium infection. Eur J Pediatr 162, 534–536 (2003). https://doi.org/10.1007/s00431-003-1199-6

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  • DOI: https://doi.org/10.1007/s00431-003-1199-6

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