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Taxane, platinum and 5-FU prior to chemoradiotherapy benefits patients with stage IV neck node-positive head and neck cancer and a good performance status

  • Original Article – Clinical Oncology
  • Published:
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Abstract

Purpose

The benefit of adding docetaxel, cisplatin and 5-fluorouracil (TPF) induction chemotherapy to chemoradiotherapy (CRT) in head and neck squamous cell carcinoma (HNSCC) remains uncertain. We aimed to investigate whether ICT is well tolerated when given with prophylactic treatment against predicted adverse effects and which patients benefit most.

Methods

A single-centre audit identified 132 HNSCC patients with stage IVa/b neck node-positive disease, prescribed TPF followed by CRT. TPF involved three cycles of docetaxel (75 mg/m2 IV) and cisplatin (75 mg/m2 IV) on day 1 plus 5-FU (750 mg/m2 IV) on days 2–5. Planned CRT was 66 Gy in 30 fractions of intensity-modulated radiotherapy with concurrent cisplatin (100 mg/m2 IV) at the beginning of week 1 and 4 (days 1 and 22). All patients received prophylactic antibiotics and granulocyte colony-stimulating factor.

Results

Median follow-up was 39.5 months. 92.4% of patients completed three cycles of TPF; 95.5% of patients started chemoradiotherapy. Grade 3/4 adverse events were low (febrile neutropenia 3.0%), with no toxicity-related deaths. 3-year overall survival was 67.2%; disease-specific survival was 78.7%; locoregional control was 78.3%. Distant metastases rate was 9.8% (3.0% in those without locoregional recurrence). Good performance status (p = 0.002) and poor tumour differentiation (p = 0.018) were associated with improved overall survival on multivariate analysis.

Conclusion

With prophylactic antibiotics and granulocyte colony-stimulating factor TPF was well tolerated with good survival outcomes. TPF should remain a treatment option for stage IV neck node-positive patients with a good performance status. The use of tumour grade to aid patient selection for TPF warrants investigation.

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References

  • Adelstein DJ, Li Y, Adams GL, Wagner H Jr, Kish JA, Ensley JF, Schuller DE, Forastiere AA (2003) An intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer. J Clin Oncol 21:92–98

    Article  PubMed  Google Scholar 

  • Ang KK, Harris J, Wheeler R, Weber R, Rosenthal DI, Nguyen-Tan PF, Westra WH, Chung CH, Jordan RC, Lu C, Kim H, Axelrod R, Silverman CC, Redmond KP, Gillison ML (2010) Human papillomavirus and survival of patients with oropharyngeal cancer N. Engl J Med 363:24–35. https://doi.org/10.1056/NEJMoa0912217

    Article  CAS  Google Scholar 

  • Ang KK, Zhang Q, Rosenthal DI, Nguyen-Tan PF, Sherman EJ, Weber RS, Galvin JM, Bonner JA, Harris J, El-Naggar AK, Gillison ML, Jordan RC, Konski AA, Thorstad WL, Trotti A, Beitler JJ, Garden AS, Spanos WJ, Yom SS, Axelrod RS (2014) Randomized phase III trial of concurrent accelerated radiation plus cisplatin with or without cetuximab for stage III to IV head and neck carcinoma: RTOG 0522. J Clin Oncol 32:2940–2950. https://doi.org/10.1200/jco.2013.53.5633

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Argiris A, Karamouzis MV, Raben D, Ferris RL (2008) Head neck cancer Lancet 371:1695–1709. https://doi.org/10.1016/s0140-6736(08)60728-x

    CAS  PubMed  Google Scholar 

  • Begg AC, Haustermans K, Hart AA, Dische S, Saunders M, Zackrisson B, Gustaffson H, Coucke P, Paschoud N, Hoyer M, Overgaard J, Antognoni P, Richetti A, Bourhis J, Bartelink H, Horiot JC, Corvo R, Giaretti W, Awwad H, Shouman T, Jouffroy T, Maciorowski Z, Dobrowsky W, Struikmans H, Wilson GD et al (1999) The value of pretreatment cell kinetic parameters as predictors for radiotherapy outcome in head and neck cancer: a multicenter analysis. Radiother Oncol 50:13–23

    Article  CAS  PubMed  Google Scholar 

  • Bentzen SM (2003) Repopulation in radiation oncology: perspectives of clinical research. Int J Radiat Biol 79:581–585

    Article  CAS  PubMed  Google Scholar 

  • Bentzen SM, Atasoy BM, Daley FM, Dische S, Richman PI, Saunders MI, Trott KR, Wilson GD (2005) Epidermal growth factor receptor expression in pretreatment biopsies from head and neck squamous cell carcinoma as a predictive factor for a benefit from accelerated radiation therapy in a randomized controlled trial. J Clin Oncol 23:5560–5567. https://doi.org/10.1200/jco.2005.06.411

    Article  CAS  PubMed  Google Scholar 

  • Bernstein JM, Kershaw LE, Withey SB, Lowe NM, Homer JJ, Slevin NJ, Bonington SC, Carrington BM, West CM (2015) Tumor plasma flow determined by dynamic contrast-enhanced MRI predicts response to induction chemotherapy in head and neck cancer. Oral Oncol 51:508–513. https://doi.org/10.1016/j.oraloncology.2015.01.013

    Article  PubMed  Google Scholar 

  • Blanchard P, Hill C, Guihenneuc-Jouyaux C, Baey C, Bourhis J, Pignon JP (2011) Mixed treatment comparison meta-analysis of altered fractionated radiotherapy and chemotherapy in head and neck cancer. J Clin Epidemiol 64:985–992. https://doi.org/10.1016/j.jclinepi.2010.10.016

    Article  PubMed  Google Scholar 

  • Bourhis J, Sire C, Graff P, Gregoire V, Maingon P, Calais G, Gery B, Martin L, Alfonsi M, Desprez P, Pignon T, Bardet E, Rives M, Geoffrois L, Daly-Schveitzer N, Sen S, Tuchais C, Dupuis O, Guerif S, Lapeyre M, Favrel V, Hamoir M, Lusinchi A, Temam S, Pinna A, Tao YG, Blanchard P, Auperin A (2012) Concomitant chemoradiotherapy versus acceleration of radiotherapy with or without concomitant chemotherapy in locally advanced head and neck carcinoma (GORTEC 99–02): an open-label phase 3 randomised trial. Lancet Oncol 13:145–153. https://doi.org/10.1016/s1470-2045(11)70346-1

    Article  PubMed  Google Scholar 

  • Brockstein B, Haraf DJ, Rademaker AW, Kies MS, Stenson KM, Rosen F, Mittal BB, Pelzer H, Fung BB, Witt M-E, Wenig B, Portugal L, Weichselbaum RW, Vokes EE (2004) Patterns of failure, prognostic factors and survival in locoregionally advanced head and neck cancer treated with concomitant chemoradiotherapy: a 9-year, 337-patient, multi-institutional experience. Ann Oncol 15:1179–1186. https://doi.org/10.1093/annonc/mdh308

    Article  CAS  PubMed  Google Scholar 

  • Budach W, Bolke E, Kammers K, Gerber PA, Orth K, Gripp S, Matuschek C (2016) Induction chemotherapy followed by concurrent radio-chemotherapy versus concurrent radio-chemotherapy alone as treatment of locally advanced squamous cell carcinoma of the head and neck (HNSCC): a meta-analysis of randomized trials radiotherapy and oncology. J Eur Soc Ther Radiol Oncol 118:238–243. https://doi.org/10.1016/j.radonc.2015.10.014

    Article  Google Scholar 

  • Byrd JK, Wilhoit CS, Fordham MT, Reeves TD, McRackan TR, Nguyen SA, Sutkowski N, Gillespie MB (2012) Predicting HPV status in head and neck cancer: the predictive value of sociodemographic and disease characteristics. Arch Otolaryngol Head Neck Surg 138:1155–1159. https://doi.org/10.1001/jamaoto.2013.850

    Article  PubMed  Google Scholar 

  • Chang PH, Yeh KY, Huang JS, Lai CH, Wu TH, Lan YJ, Tsai JC, Chen EY, Yang SW, Wang CH (2013) Pretreatment performance status and nutrition are associated with early mortality of locally advanced head and neck cancer patients undergoing concurrent chemoradiation. Eur Arch Otorhinolaryngol 270:1909–1915. https://doi.org/10.1007/s00405-012-2290-2

    Article  PubMed  Google Scholar 

  • Cohen EE, Karrison T, Kocherginsky M, al e (2012) Docetaxel based chemoradiotherapy plus or minus induction chemotherapy to decrease events in head and neck cancer (DeCIDE). J Clin Oncol 30:suppl 5500

    Google Scholar 

  • Cohen EE, Karrison TG, Kocherginsky M, Mueller J, Egan R, Huang CH, Brockstein BE, Agulnik MB, Mittal BB, Yunus F, Samant S, Raez LE, Mehra R, Kumar P, Ondrey F, Marchand P, Braegas B, Seiwert TY, Villaflor VM, Haraf DJ, Vokes EE (2014) Phase III randomized trial of induction chemotherapy in patients with N2 or N3 locally advanced head and neck cancer. J Clin Oncol 32:2735–2743. https://doi.org/10.1200/jco.2013.54.6309

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dahlstrom KR, Adler-Storthz K, Etzel CJ, Liu Z, Dillon L, El-Naggar AK, Spitz MR, Schiller JT, Wei Q, Sturgis EM (2003) Human papillomavirus type 16 infection and squamous cell carcinoma of the head and neck in never-smokers: a matched pair analysis. Clin Cancer Res 9:2620–2626

    PubMed  Google Scholar 

  • Dayyani F, Etzel CJ, Liu M, Ho CH, Lippman SM, Tsao AS (2010) Meta-analysis of the impact of human papillomavirus (HPV) on cancer risk and overall survival in head and neck squamous cell carcinomas (HNSCC). Head Neck Oncol 2:15. https://doi.org/10.1186/1758-3284-2-15

    Article  PubMed  PubMed Central  Google Scholar 

  • Dische S, Saunders M, Barrett A, Harvey A, Gibson D, Parmar M (1997) A randomised multicentre trial of CHART versus conventional radiotherapy in head and neck cancer. Radiother Oncol 44:123–136

    Article  CAS  PubMed  Google Scholar 

  • Edge SE, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A (2009) AJCC Cancer Staging Manual, 7th edn. Spinger, New York

    Google Scholar 

  • Eriksen JG, Steiniche T, Overgaard J (2005) The influence of epidermal growth factor receptor and tumor differentiation on the response to accelerated radiotherapy of squamous cell carcinomas of the head and neck in the randomized DAHANCA 6 and 7study. Radiother Oncol 74:93–100

    Article  CAS  PubMed  Google Scholar 

  • Feyer PC, Maranzano E, Molassiotis A, Roila F, Clark-Snow RA, Jordan K (2011) Radiotherapy-induced nausea and vomiting (RINV): MASCC/ESMO guideline for antiemetics in radiotherapy: update 2009. Support Care Cancer 19 Suppl 1:S5–S14. https://doi.org/10.1007/s00520-010-0950-6

  • Fortin A, Couture C, Doucet R, Albert M, Allard J, Tetu B (2001) Does histologic grade have a role in the management of head and neck cancers? J Clin Oncol 19:4107–4116. https://doi.org/10.1200/jco.2001.19.21.4107

    Article  CAS  PubMed  Google Scholar 

  • Garavello W, Ciardo A, Spreafico R, Gaini RM (2006) Risk factors for distant metastases in head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 132:762–766. https://doi.org/10.1001/archotol.132.7.762

    Article  PubMed  Google Scholar 

  • Ghi MG, Paccagnella A, D Ferrari, P Foa, MC Rocca, E Verri, F Morelli, G Azzarello, C D’Ambrosio, G Cruciani, M Guaraldi, E Massa, C Rossetto, A Bonetti, S Siena, V Minotti, H Koussis, G Pieri, V Baggio, I Floriani, Group ftGIS (2014) Concomitant chemoradiation (CRT) or cetuximab/RT (CET/RT) versus induction Docetaxel/ Cisplatin/5-Fluorouracil (TPF) followed by CRT or CET/RT in patients with Locally Advanced Squamous Cell Carcinoma of Head and Neck (LASCCHN). A randomized phase III factorial study (NCT01086826). J Clin Oncol 32:6004

    Google Scholar 

  • Ghi MG, Paccagnella A, Ferrari D, Foa P, Alterio D, Codeca C, Nole F, Verri E, Orecchia R, Morelli F, Parisi S, Mastromauro C, Mione CA, Rossetto C, Polsinelli M, Koussis H, Loreggian L, Bonetti A, Campostrini F, Azzarello G, D’Ambrosio C, Bertoni F, Casanova C, Emiliani E, Guaraldi M, Bunkheila F, Bidoli P, Niespolo RM, Gava A, Massa E, Frattegiani A, Valduga F, Pieri G, Cipani T, Da Corte D, Chiappa F, Rulli E (2017) Induction TPF followed by concomitant treatment versus concomitant treatment alone in locally advanced head and neck cancer. A phase II-III trial. Ann Oncology 28:2206–2212. https://doi.org/10.1093/annonc/mdx299

    CAS  Google Scholar 

  • Gillison ML, Koch WM, Capone RB, Spafford M, Westra WH, Wu L, Zahurak ML, Daniel RW, Viglione M, Symer DE, Shah KV, Sidransky D (2000) Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst 92:709–720

    Article  CAS  PubMed  Google Scholar 

  • Guo T, Qualliotine JR, Ha PK, Califano JA, Kim Y, Saunders JR, Blanco RG, D’Souza G, Zhang Z, Chung CH, Kiess A, Gourin CG, Koch W, Richmon JD, Agrawal N, Eisele DW, Fakhry C (2015) Surgical salvage improves overall survival for patients with HPV-positive and HPV-negative recurrent locoregional and distant metastatic oropharyngeal cancer. Cancer 121:1977–1984. https://doi.org/10.1002/cncr.29323

    Article  PubMed  PubMed Central  Google Scholar 

  • Hansen O, Overgaard J, Hansen HS, Overgaard M, Hoyer M, Jorgensen KE, Bastholt L, Berthelsen A (1997) Importance of overall treatment time for the outcome of radiotherapy of advanced head and neck carcinoma: dependency on tumor differentiation. Radiother Oncol 43:47–51

    Article  CAS  PubMed  Google Scholar 

  • Hitt R, Grau JJ, Lopez-Pousa A, Berrocal A, Garcia-Giron C, Irigoyen A, Sastre J, Martinez-Trufero J, Brandariz Castelo JA, Verger E, Cruz-Hernandez JJ (2014) A randomized phase III trial comparing induction chemotherapy followed by chemoradiotherapy versus chemoradiotherapy alone as treatment of unresectable head and neck cancer. Ann Oncol 25:216–225. https://doi.org/10.1093/annonc/mdt461

    Article  CAS  PubMed  Google Scholar 

  • Huang SH, Perez-Ordonez B, Liu FF, Waldron J, Ringash J, Irish J, Cummings B, Siu LL, Kim J, Weinreb I, Hope A, Gullane P, Brown D, Shi W, O’Sullivan B (2012) A typical clinical behavior of p16-confirmed HPV-related oropharyngeal squamous cell carcinoma treated with radical radiotherapy. Int J Radiat Oncol Biol Phys 82:276–283. https://doi.org/10.1016/j.ijrobp.2010.08.031

    Article  PubMed  Google Scholar 

  • Kies MS, Holsinger FC, Lee JJ, William WN Jr, Glisson BS, Lin HY, Lewin JS, Ginsberg LE, Gillaspy KA, Massarelli E, Byers L, Lippman SM, Hong WK, El-Naggar AK, Garden AS, Papadimitrakopoulou V (2010) Induction chemotherapy and cetuximab for locally advanced squamous cell carcinoma of the head and neck: results from a phase II prospective trial. J Clin Oncol 28:8–14. https://doi.org/10.1200/jco.2009.23.0425

    Article  CAS  PubMed  Google Scholar 

  • Lorch JH, Goloubeva O, Haddad RI, Cullen K, Sarlis N, Tishler R, Tan M, Fasciano J, Sammartino DE, Posner MR (2011) Induction chemotherapy with cisplatin and fluorouracil alone or in combination with docetaxel in locally advanced squamous-cell cancer of the head and neck: long-term results of the TAX 324 randomised phase 3 trial. Lancet Oncol 12:153–159. https://doi.org/10.1016/s1470-2045(10)70279-5

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ma J, Liu Y, Huang XL, Zhang ZY, Myers JN, Neskey DM, Zhong LP (2012) Induction chemotherapy decreases the rate of distant metastasis in patients with head and neck squamous cell carcinoma but does not improve survival or locoregional control: a meta-analysis. Oral Oncol 48:1076–1084. https://doi.org/10.1016/j.oraloncology.2012.06.014

    Article  CAS  PubMed  Google Scholar 

  • Miah AB, Schick U, Bhide SA, Guerrero-Urbano MT, Clark CH, Bidmead AM, Bodla S, Del Rosario L, Thway K, Wilson P, Newbold KL, Harrington KJ, Nutting CM (2015) A phase II trial of induction chemotherapy and chemo-IMRT for head and neck squamous cell cancers at risk of bilateral nodal spread: the application of a bilateral superficial lobe parotid-sparing IMRT technique and treatment outcomes. Br J Cancer 112:32–38. https://doi.org/10.1038/bjc.2014.553

    Article  CAS  PubMed  Google Scholar 

  • Nguyen-Tan PF, Zhang Q, Ang KK, Weber RS, Rosenthal DI, Soulieres D, Kim H, Silverman C, Raben A, Galloway TJ, Fortin A, Gore E, Westra WH, Chung CH, Jordan RC, Gillison ML, List M, Le Q-T (2014) Randomized phase III trial to test accelerated versus standard fractionation in combination with concurrent cisplatin for head and neck carcinomas in the radiation therapy oncology group 0129 trial: long-term report of efficacy and toxicity. J Clin Oncol. https://doi.org/10.1200/jco.2014.55.3925

    Google Scholar 

  • O’Sullivan B, Huang SH, Perez-Ordonez B, Massey C, Siu LL, Weinreb I, Hope A, Kim J, Bayley AJ, Cummings B, Ringash J, Dawson LA, Cho BC, Chen E, Irish J, Gilbert RW, Hui A, Liu FF, Zhao H, Waldron JN, Xu W (2012) Outcomes of HPV-related oropharyngeal cancer patients treated by radiotherapy alone using altered fractionation. Radiother Oncol 103:49–56. https://doi.org/10.1016/j.radonc.2012.02.009

    Article  PubMed  Google Scholar 

  • Oken MM, Creech RH, Tormey DC, Horton J, Davis TE, McFadden ET, Carbone PP (1982) Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol 5:649–655

    Article  CAS  PubMed  Google Scholar 

  • Petrelli F, Sarti E, Barni S (2014) Predictive value of human papillomavirus in oropharyngeal carcinoma treated with radiotherapy: An updated systematic review and meta-analysis of 30 trials. Head Neck 36:750–759. https://doi.org/10.1002/hed.23351

    Article  PubMed  Google Scholar 

  • Pignon J-P, Maître A, Maillard E, Bourhis J (2009) Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 93 randomised trials and 17,346 patients. Radiother Oncol 92:4–14. https://doi.org/10.1016/j.radonc.2009.04.014

    Article  PubMed  Google Scholar 

  • Pointreau Y, Garaud P, Chapet S, Sire C, Tuchais C, Tortochaux J, Faivre S, Guerrif S, Alfonsi M, Calais G (2009) Randomized trial of induction chemotherapy with cisplatin and 5-fluorouracil with or without docetaxel for larynx preservation. J Natl Cancer Inst 101:498–506. https://doi.org/10.1093/jnci/djp007

    Article  CAS  PubMed  Google Scholar 

  • Posner MR, Hershock DM, Blajman CR, Mickiewicz E, Winquist E, Gorbounova V, Tjulandin S, Shin DM, Cullen K, Ervin TJ, Murphy BA, Raez LE, Cohen RB, Spaulding M, Tishler RB, Roth B, Viroglio Rdel C, Venkatesan V, Romanov I, Agarwala S, Harter KW, Dugan M, Cmelak A, Markoe AM, Read PW, Steinbrenner L, Colevas AD, Norris CM Jr, Haddad RI (2007) Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer. N Engl J Med 357:1705–1715. https://doi.org/10.1056/NEJMoa070956

    Article  CAS  PubMed  Google Scholar 

  • Posner MR, Lorch JH, Goloubeva O, Tan M, Schumaker LM, Sarlis NJ, Haddad RI, Cullen KJ (2011) Survival and human papillomavirus in oropharynx cancer in TAX 324: a subset analysis from an international phase III. trial Ann Oncol 22:1071–1077. https://doi.org/10.1093/annonc/mdr006

    Article  CAS  PubMed  Google Scholar 

  • Prestwich RJ, Öksüz D, Dyker K, Coyle C, Şen M (2011) Feasibility and efficacy of induction docetaxel, cisplatin, and 5-fluorouracil chemotherapy combined with cisplatin concurrent chemoradiotherapy for nonmetastatic stage iv head-and-neck squamous cell carcinomas. Int J Radiat Oncol Biol Phys 81:e237–e243 https://doi.org/10.1016/j.ijrobp.2011.03.043

    Article  CAS  PubMed  Google Scholar 

  • Sinha P, Thorstad WT, Nussenbaum B, Haughey BH, Adkins DR, Kallogjeri D, Lewis Jr (2014) JS Distant metastasis in p16-positive oropharyngeal squamous cell carcinoma: a critical analysis of patterns and outcomes. Oral oncology 50:45–51. https://doi.org/10.1016/j.oraloncology.2013.10.007

    Article  CAS  PubMed  Google Scholar 

  • Slevin NJ, West CM, Wilson GD, Hendry JH (1999) The potential benefit from individualised radiotherapy scheduling for head and neck tumours on the basis of both histological grade and kinetics. Radiother Oncol 51:109–111

    Article  CAS  PubMed  Google Scholar 

  • Stokes WA, Amini A, Jones BL, McDermott JD, Raben D, Ghosh D, Goddard JA, Bowles DW, Karam SD (2017) Survival impact of induction chemotherapy in advanced head and neck cancer: A National Cancer Database analysis. Head Neck 39:1113–1121. https://doi.org/10.1002/hed.24739

    Article  PubMed  Google Scholar 

  • Takacsi-Nagy Z, Hitre E, Remenar E, Oberna F, Polgar C, Major T, Godeny M, Fodor J, Kasler M (2015) Docetaxel, cisplatin and 5-fluorouracil induction chemotherapy followed by chemoradiotherapy or chemoradiotherapy alone in stage III-IV unresectable head and neck cancer: Results of a randomized phase. II study Strahlenther Onkol 191:635–641. https://doi.org/10.1007/s00066-015-0829-z

    Article  PubMed  Google Scholar 

  • Trosman SJ, Koyfman SA, Ward MC, Al-Khudari S, Nwizu T, Greskovich JF, Lamarre ED, Scharpf J, Khan MJ, Lorenz RR, Adelstein DJ, Burkey BB (2015) Effect of human papillomavirus on patterns of distant metastatic failure in oropharyngeal squamous cell carcinoma treated with chemoradiotherapy. JAMA Otolaryngol Head Neck Surg 141:457–462. https://doi.org/10.1001/jamaoto.2015.136

    Article  PubMed  Google Scholar 

  • Trotti A, Byhardt R, Stetz J, Gwede C, Corn B, Fu K, Gunderson L, McCormick B, Morrisintegral M, Rich T, Shipley W, Curran W (2000) Common toxicity criteria: version 2.0. an improved reference for grading the acute effects of cancer treatment: impact on radiotherapy. Int J Radiat Oncol Biol Phys 47:13–47

    Article  CAS  PubMed  Google Scholar 

  • Vermorken JB, Remenar E, van Herpen C, Gorlia T, Mesia R, Degardin M, Stewart JS, Jelic S, Betka J, Preiss JH, van den Weyngaert D, Awada A, Cupissol D, Kienzer HR, Rey A, Desaunois I, Bernier J, Lefebvre JL (2007) Cisplatin, fluorouracil, and docetaxel in unresectable head and neck cancer. N Engl J Med 357:1695–1704. https://doi.org/10.1056/NEJMoa071028

    Article  CAS  PubMed  Google Scholar 

  • Vidal L, Ben Aharon I, Limon D, Cohen E, Popovtzer A (2017) Role of induction chemotherapy prior to chemoradiation in head and neck squamous cell cancer—systematic review and meta-analysis. Cancer J 23:79–83. https://doi.org/10.1097/ppo.0000000000000253

    Article  CAS  PubMed  Google Scholar 

  • Wilson GD, Saunders MI, Dische S, Daley FM, Buffa FM, Richman PI, Bentzen SM (2006) Pre-treatment proliferation and the outcome of conventional and accelerated radiotherapy. Eur J Cancer 42:363–371. https://doi.org/10.1016/j.ejca.2005.10.022

    Article  PubMed  Google Scholar 

  • Won HS, Lee YS, Jeon EK, Hong SH, Kang JH, Kim YS, Yoo le R, Sun DI, Kim MS (2014) Clinical outcome of induction chemotherapy in locally advanced head and neck squamous cell carcinoma. Anticancer Res 34:5709–5714

    CAS  PubMed  Google Scholar 

  • Zhang L, Jiang N, Shi Y, Li S, Wang P, Zhao Y (2015) Induction chemotherapy with concurrent chemoradiotherapy versus concurrent chemoradiotherapy for locally advanced squamous cell carcinoma of head and neck: a meta-analysis. Sci Rep 5:10798. https://doi.org/10.1038/srep10798

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • National Cancer Institute (NCI, NIH, DHHS. May 29, 2009) Common Terminology Criteria for Adverse Events v4.0

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Acknowledgements

The authors acknowledge Jason Kennedy and Lucy E. Kershaw for help and support on the database management, Clare Hodgson for statistical review and Helen Valentine for p16 immunostaining.

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Authors and Affiliations

  1. Translational Radiobiology Group, Division of Cancer Sciences, Manchester Academic Health Science Centre, NIHR Manchester Biomedical Research Centre, The Christie NHS Foundation Trust, University of Manchester, Wilmslow Road, Manchester, England, M20 4BX, UK

    Natalie M. Lowe, Jonathan M. Bernstein, David J. Thomson, Jarrod J. Homer, Catharine M. West & Nicholas J. Slevin

  2. Head and Neck Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Manchester, England, M20 4BX, UK

    Natalie M. Lowe, Kathleen Mais, Kate Garcez, Lip W. Lee, Andrew Sykes, David J. Thomson & Nicholas J. Slevin

  3. University Department of Otolaryngology-Head & Neck Surgery, Manchester Academic Health Science Centre, Manchester Royal Infirmary, Central Manchester University Hospitals NHS Foundation Trust, University of Manchester, Oxford Road, Manchester, England, M13 9WL, UK

    Jarrod J. Homer

  4. Department of Otolaryngology-Head and Neck Surgery, The Royal Marsden NHS Foundation Trust, The Royal Marsden, Fulham Road, London, SW3 6JJ, UK

    Jonathan M. Bernstein

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  1. Natalie M. Lowe
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Correspondence to Natalie M. Lowe.

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Funding

This study was supported by Cancer Research UK Major Centre funding, the Christie NHS Foundation Trust and NIHR Manchester Biomedical Research Centre.

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All authors report no conflicts of interest.

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This article does not contain any studies with human participants performed by any of the authors. For this type of study, formal consent is not required. Ethics approval for the staining of tumour samples for p16 was granted by National Research Ethics Service; NRES Committee North West–Greater Manchester East, reference number: 03/TG/076.

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Lowe, N.M., Bernstein, J.M., Mais, K. et al. Taxane, platinum and 5-FU prior to chemoradiotherapy benefits patients with stage IV neck node-positive head and neck cancer and a good performance status. J Cancer Res Clin Oncol 144, 389–401 (2018). https://doi.org/10.1007/s00432-017-2553-9

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