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Development of diagnostic and treatment strategies for glaucoma through understanding and modification of scleral and lamina cribrosa connective tissue

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Abstract

Considerable evidence indicates that the state of ocular connective tissues and their response in glaucomatous disease affect the degree of glaucoma damage. Both experimental and clinical data suggest that improved diagnostic and prognostic information can be derived from the assessment of the mechanical responsiveness of the sclera and lamina cribrosa to intraocular pressure (IOP). Controlled mutagenesis of the sclera has produced a mouse strain that is relatively resistant to increased IOP. Alteration of the baseline scleral state can be accomplished through either increased cross-linking of fibrillar components or their reduction. The sclera is a dynamic structure, altering its structure and behavior in response to IOP change. The biochemical pathways that control these responses are fertile areas for new glaucoma treatments.

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Acknowledgments

The authors thank the members of their laboratory who contributed to the work presented here: Mary Ellen Pease, Ericka Oglesby, Matthew Steinhart and Cathy Nguyen. Faculty collaborators who provided important expertise included Thao (Vicky) Nguyen, Baptiste Coudrillier, Keith Meek, Craig Boote, Justin Hanes, Gulgun Tezel, Don Zack and Derek Welsbie.

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  1. Glaucoma Center of Excellence, Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Harry A. Quigley & Frances E. Cone

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  1. Harry A. Quigley
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Correspondence to Frances E. Cone.

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Quigley, H.A., Cone, F.E. Development of diagnostic and treatment strategies for glaucoma through understanding and modification of scleral and lamina cribrosa connective tissue. Cell Tissue Res 353, 231–244 (2013). https://doi.org/10.1007/s00441-013-1603-0

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