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Patient-specific neural progenitor cells derived from induced pluripotent stem cells offer a promise of good models for mitochondrial disease

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Abstract

Mitochondria are the primary generators of ATP in eukaryotic cells through the process of oxidative phosphorylation. Mitochondria are also involved in several other important cellular functions including regulation of intracellular Ca2+, cell signaling and apoptosis. Mitochondrial dysfunction causes disease and since it is not possible to perform repeated studies in humans, models are essential to enable us to investigate the mechanisms involved. Recently, the discovery of induced pluripotent stem cells (iPSCs), made by reprogramming adult somatic cells (Takahashi and Yamanaka 2006; Yamanaka and Blau 2010), has provided a unique opportunity for studying aspects of disease mechanisms in patient-specific cells and tissues. Reprogramming cells to neuronal lineage such as neural progenitor cells (NPCs) generated from the neural induction of reprogrammed iPSCs can thus provide a useful model for investigating neurological disease mechanisms including those caused by mitochondrial dysfunction. In addition, NPCs display a huge clinical potential in drug screening and therapeutics.

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Funding

This work was supported by funding from the Norwegian Research Council (project no. 229652), Rakel og Otto Kr.Bruuns legat and Meltzer (project no.809432).

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Authors and Affiliations

  1. The Mitochondrial Medicine and Neurogenetics (MMN) Group, Department of Clinical Medicine, University of Bergen, PO Box 7804, 5020, Bergen, Norway

    Xiao Liang, Cecilie Katrin Kristiansen, Guro Helén Vatne & Laurence Albert Bindoff

  2. Department of Neurology, Haukeland University Hospital, Bergen, Norway

    Xiao Liang, Yu Hong & Laurence Albert Bindoff

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  1. Xiao Liang
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  2. Cecilie Katrin Kristiansen
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  3. Guro Helén Vatne
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  4. Yu Hong
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  5. Laurence Albert Bindoff
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Contributions

X.L, and L.A.B: Conceptualization;

X.L, C.K.K, and G.H.V: Writing Original Draft;

X.L, C.K.K, G.H.V, Y.H, and L.A.B: Writing Review & Editing;

L.A.B: Funding Acquisition;

X.L: Supervision.

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Correspondence to Xiao Liang.

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Liang, X., Kristiansen, C.K., Vatne, G.H. et al. Patient-specific neural progenitor cells derived from induced pluripotent stem cells offer a promise of good models for mitochondrial disease. Cell Tissue Res 380, 15–30 (2020). https://doi.org/10.1007/s00441-019-03164-x

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  • DOI: https://doi.org/10.1007/s00441-019-03164-x

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