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Voltammetric detection of anti-HIV replication drug based on novel nanocomposite gold-nanoparticle–CaCO3 hybrid material

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A Correction to this article was published on 11 March 2019

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Abstract

A novel bionanocomposite, horse radish peroxidase- gold-nanoparticle–Calcium carbonate (HRP-AuNPs-CaCO3), hybrid material was encapsulated by silica sol on a glassy carbon electrode (GCE). The fabricated modified electrode was used as a novel voltammetric sensor for electrochemical sensing of anti-HIV replication drug i.e. deferiprone. The surface morphology of the modified electrode was characterized by scanning electron microscopy (SEM). Results obtained from the voltammetric measurements show that HRP-AuNPs-CaCO3 modified GCE offers a selective and sensitive electrochemical sensor for the determination of deferiprone. Under experimental conditions, the proposed voltammetric sensor has a linear response range from 0.01 to 10,000 μM with a detection limit of 0.01 μM. Furthermore, the fabricated sensor was successfully applied to determine deferiprone level in spiked urine and serum samples.

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  • 11 March 2019

    The Figs.��2, 4 and 5 were published wrongly in this paper, due to inadvertent compilation of figures during uploading the paper.

  • 11 March 2019

    The Figs.��2, 4 and 5 were published wrongly in this paper, due to inadvertent compilation of figures during uploading the paper.

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Acknowledgments

In the present work, one of the author (Jagriti Narang) was supported by SERB, Department of Science and Technology (DST), India. Thanks to all scientists referenced throughout the paper whose valuable work has guided the way through to this research work.

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Authors and Affiliations

  1. Amity Institute of Nanotechnology, AMITY University, Noida, UP, India

    Jagriti Narang

  2. Amity Institute of Physiotherapy, AMITY University, Noida, UP, India

    Nitesh Malhotra

  3. Faculty of Pharmaceutical Science PGIMS, Rohtak, India

    Gajendra Singh

  4. Department of Biochemistry, M. D. University, Rohtak, 124001, Haryana, India

    C. S. Pundir

Authors
  1. Jagriti Narang
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  2. Nitesh Malhotra
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  3. Gajendra Singh
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  4. C. S. Pundir
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Correspondence to Jagriti Narang.

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Narang, J., Malhotra, N., Singh, G. et al. Voltammetric detection of anti-HIV replication drug based on novel nanocomposite gold-nanoparticle–CaCO3 hybrid material. Bioprocess Biosyst Eng 38, 815–822 (2015). https://doi.org/10.1007/s00449-014-1323-1

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  • DOI: https://doi.org/10.1007/s00449-014-1323-1

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