Skip to main content
SpringerLink
Log in

An unusual DMSA scan: answer

  • Clinical Quiz
  • Published:
Pediatric Nephrology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Lloyd SE, Gunther W, Pearce SH, Thomson A, Bianchi ML, Bosio M, Craig IW, Fisher SE, Scheinman SJ, Wrong O, Jentsch TJ, Thakker RV (1997) Characterisation of renal chloride channel, CLCN5, mutations in hypercalciuric nephrolithiasis (kidney stone) disorders. Hum Mol Genet 8:1233–1239

    Article  Google Scholar 

  2. Muller-Suur R, Gutsche HU (1995) Tubular reabsorption of technetium-99 m-DMSA. J Nucl Med 36(9):1654–1658

    PubMed  CAS  Google Scholar 

  3. Gambaro G, Vezzoli G, Casari G, Rampoldi L, D'Angelo A, Borghi L (2004) Genetics of hypercalciuria and calcium nephrolithiasis: from the rare monogenic to the common polygenic forms. Am J Kidney Dis 44:963–986

    Article  PubMed  CAS  Google Scholar 

  4. Dent CE, Friedman M (1964) Hypercalciuric rickets associated with renal tubular damage. Arch Dis Child 39:240–249

    Article  PubMed  CAS  Google Scholar 

  5. Wrong OM, Norden AGW, Feest TG (1994) Dent's disease: a familial proximal renal tubular syndrome with low-molecular-weight proteinuria, hypercalciuria, nephrocalcinosis, metabolic bone disease, progressive renal failure and a marked male predominance. Quart J Med 87:473–493

    CAS  Google Scholar 

  6. Ludwig M, Utsch B, Monnens L (2006) Recent advances in understanding the clinical and genetic heterogeneity of Dent’s disease. Nephrol Dial Transplant 21:2708–2717

    Article  PubMed  Google Scholar 

  7. Lee BH, Lee SH, Chol HJ, Kang HG, Oh SW, Lee DS, Ha HS, Choi Y, Cheong HI (2006) Decreased renal uptake of 99mTc-DMSA in patients with tubular proteinuria. Pediatr Nephrol 24:2211–2216

    Article  Google Scholar 

  8. Suzuki S, Suzuki J, Kume K, Yoshida K, Suyama H, Kawasaki Y, Nozawa R, Suzuki H, Fujiki T, Kamiyama S, Suzuki A (1999) Poor renal accumulation of 99mTc-DMSA in idiopathic tubular proteinuria. Nephron 81:49–54

    Article  PubMed  CAS  Google Scholar 

  9. Ludwig M, Utsch B, Balluch B, Fruend S, Kuwertz-Broeking E, Boekenkamp A (2006) Hypercalciuria in patients with CLCN5 mutations. Pediatr Nephrol 21:1241–1250

    Article  PubMed  Google Scholar 

  10. Smith AJ, Reed A, Loh NY, Thakker RV, Lippiat JD (2009) Characterization of Dent's disease mutations of CLC-5 reveals a correlation between functional and cell biological consequences and protein structure. Am J Physiol Renal Physiol 296:F390–F397

    Article  PubMed  CAS  Google Scholar 

  11. Devuyst O, Jouret F, Auzanneau C, Courtoy PJ (2005) Chloride channels and endocytosis: new insights from Dent’s disease and CIC-5 knockout mice. Nephron Physiol 99:69–73

    Article  Google Scholar 

  12. Raja KA, Schurman S, D'mello RG, Blowey D, Goodyer P, Van Why S, Ploutz-Snyder RJ, Asplin J, Scheinman SJ (2002) Responsiveness of hypercalciuria to thiazide in Dent’s disease. J Am Soc Nephrol 13:2938–2944

    Article  PubMed  Google Scholar 

  13. Blanchard A, Vargas-Poussou R, Peyrard S, Mogenet A, Baudouin V, Boudailliez B, Charbit M, Deschesnes G, Ezzhair N, Loirat C, Macher MA, Niaudet P, Azizi M (2008) Effect of hydrochlorothiazide on urinary calcium excretion in dent disease: an uncontrolled trial. Am J Kidney Dis 52:1084–1095

    Article  PubMed  CAS  Google Scholar 

  14. Cebotaru V, Kaul S, Devuyst O, Cai H, Racusen L, Guggino WB, Guggino SE (2005) High citrate diet delays progression of renal insufficiency in the CIC-5 knockout mouse model of Dent’s disease. Kidney Int 68:642–652

    Google Scholar 

  15. Levtchenko E, Blom H, Wilmer M, van den Heuvel L, Monnens L (2003) ACE inhibitor enalapril diminishes albuminuria in patients with cystinosis. Clin Nephrol 60:386–389

    PubMed  CAS  Google Scholar 

  16. Caglar M, Yaris N, Akyuz C (2001) The utility of 99mTc-DMSA and Tc99-EC scintigraphy for early diagnosis of ifosfamide induced nephrotoxicity. Nuc Med Comm 22:1325–1332

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We would like to thank the staff at the Human Genetics Dept, University Medical Centre, Nijmegen, Netherlands, for undertaking the genetic analysis.

Author information

Authors and Affiliations

  1. Alder Hey Children’s NHS Foundation Trust, Eaton Road, Liverpool, L12 2AP, UK

    Alison Timmis, Caroline Jones & Fauzia Paize

Authors
  1. Alison Timmis
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Caroline Jones
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Fauzia Paize
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Alison Timmis.

Additional information

This refers to the article that can be found at doi:10.1007/s00467-011-1912-z.

Answer: Tubulopathy secondary to Dent disease.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Timmis, A., Jones, C. & Paize, F. An unusual DMSA scan: answer. Pediatr Nephrol 27, 225–227 (2012). https://doi.org/10.1007/s00467-011-1914-x

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00467-011-1914-x

Keywords

Search

Navigation