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The renin–angiotensin–aldosterone system in 2011: role in hypertension and chronic kidney disease

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Abstract

Over the past two decades, considerable advances have been made in our understanding of the renin–angiotensin–aldosterone system (RAAS) and its roles in various disease states. In this review, we will discuss the current state of knowledge of the many components of the RAAS, including new data on prorenin and its receptors, and important angiotensin fragments. The roles of these components of the RAAS in the pathogenesis of primary hypertension and the progression of chronic kidney disease (CKD) will also be highlighted. Given the new understanding of the many components and roles of the RAAS, it may be possible to develop improved therapies for hypertension and CKD.

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  1. Pediatric Nephrology Unit, Department of Pediatrics, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil

    Ana Cristina Simões e Silva

  2. Division of Nephrology, Seattle Children’s Hospital, 4800 Sand Point Way NE, Seattle, WA, 98105, USA

    Joseph T. Flynn

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Simões e Silva, A.C., Flynn, J.T. The renin–angiotensin–aldosterone system in 2011: role in hypertension and chronic kidney disease. Pediatr Nephrol 27, 1835–1845 (2012). https://doi.org/10.1007/s00467-011-2002-y

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